Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, our guests have long been laying the groundwork for innovations that are transforming industries today.In this episode, a16z General Partner Martin Casado joins Fei-Fei and Justin to explore the journey from early AI winters to the rise of deep learning and the rapid expansion of multimodal AI. From foundational advancements like ImageNet to the cutting-edge realm of spatial intelligence, Fei-Fei and Justin share the breakthroughs that have shaped the AI landscape and reveal what's next for innovation at World Labs.If you're curious about how AI is evolving beyond language models and into a new realm of 3D, generative worlds, this episode is a must-listen.Resources: Learn more about World Labs: https://www.worldlabs.aiFind Fei-Fei on Twitter: https://x.com/drfeifeiFind Justin on Twitter: https://x.com/jcjohnss Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This week in consumer tech: Apple’s big reveals, OpenAI’s multi-step reasoning, and Adobe Firefly’s video model.Olivia Moore and Justine Moore, Partners on the a16z Consumer team, break down the latest announcements and how these product launches will shape the tech ecosystem, transform AI-powered experiences, and impact startups competing for attention in a fast-moving market. Resources: Find Justine of Twitter: https://x.com/venturetwinsFind Olivia on Twitter: https://x.com/omooretweets Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Vijay Pande, founding general partner, and Julie Yoo, general partner at a16z Bio + Health, come together to discuss the grand challenges facing healthcare AI today.The talk through the implications of AI integration in healthcare workflows, AI as a potential catalyst for value-based care, and the opportunity for innovation in clinical trials. They also talk about the AI startup they each wish would walk through the door.  Resources: Find Vijay on Twitter: https://x.com/vijaypandeFInd Julie on Twitter: https://x.com/julesyooListen to more episode from Raising Health: https://a16z.com/podcasts/raising-health/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @NoahRFeldman, @ahall_research, @rhhackettWelcome to web3 with a16z. I'm Robert Hackett and today we have a special episode about governance in many forms — from nation states to corporate boards to internet services and beyond.Our special guests are Noah Feldman, constitutional law scholar at Harvard who also architected the Meta oversight board (among many other things); he is also the author of several books. And our other special guest is Andy Hall, professor of political science at Stanford who is an advisor of a16z crypto research — and who also co-authored several papers and posts about web3 as a laboratory for designing and testing new political systems, including new work we'll link to in the shownotes.Our hallway style conversation covers technologies and approaches to governance, from constitutions to crypto/ blockchains and DAOs. As such we also discuss content moderation and community standards; best practices for citizens assemblies; courts vs. legislatures; and much more where governance comes up. Throughout, we reference the history and evolution of democracy — from Ancient Greece to the present day — as well as examples of governance from big companies like Meta, to startups like Anthropic.Resources for references in this episode:On the U.S. Supreme Court case NetChoice, LLC v. Paxton (Scotusblog)On Meta's oversight board (Oversightboard.com)On Anthropic's long term benefit trust (Anthropic, September 2023)On "Boaty McBoatface" winning a boat-naming poll (Guardian, April 2016)On Athenian democracy (World History Encyclopedia, April 2018)The Three Lives of James Madison: Genius, Partisan, President by Noah Feldman (Random House, October 2017)A selection of recent posts and papers by Andrew Hall:The web3 governance lab: Using DAOs to study political institutions and behavior at scale by Andrew Hall and Eliza Oak (a16z crypto, June 2024)DAO research: A roadmap for experimenting with governance by Andrew Hall and Eliza Oak (a16z crypto, June 2024)The effects of retroactive rewards on participating in online governance by Andrew Hall and Eliza Oak (a16z crypto, June 2024)Lightspeed Democracy: What web3 organizations can learn from the history of governance by Andrew Hall and Porter Smith (a16z crypto, June 2023)What Kinds of Incentives Encourage Participation in Democracy? Evidence from a Massive Online Governance Experiment by Andrew Hall and Eliza Oak (working paper, November 2023)Bringing decentralized governance to tech platforms with Andrew Hall (a16z crypto Youtube, July 2022)The evolution of decentralized governance with Andrew Hall (a16z crypto Youtube, July 2022)Toppling the Internet’s Accidental Monarchs: How to Design web3 Platform Governance by Porter Smith and Andrew Hall (a16z crypto, October 2022)Paying People to Participate in Governance by Ethan Bueno de Mesquita and Andrew Hall (a16z crypto, November 2022)As a reminder: none of the following should be taken as tax, business, legal, or investment advice. See a16zcrypto.com/disclosures for more important information, including a link to a list of our investments.

Half of prescribed medications are never taken, and 88% of Americans are metabolically unhealthy. Despite spending 20% of our GDP on healthcare—twice that of any other developed nation—our outcomes still lag behind.In this episode, we explore why technologists must step into the healthcare ring. Solving medicine isn’t enough; we need to make healthcare a consumer-focused industry. a16z’s Vijay Pandey and Daisy Wolf discuss the rise of tech founders in healthcare, the potential of AI to transform patient care, and how this shift could lead to the next trillion-dollar company.Can tech truly disrupt this complex, regulated industry? Resources: Read the article ‘It’s Time to Build in Healthcare’: https://a16z.com/hey-tech-its-time-to-build-in-healthcare/Find Vijay on Twitter: https://x.com/vijaypandeFind Daisy on Twitter: https://x.com/daisydwolf Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Latin America is emerging as a tech powerhouse, but it's not a one-size-fits-all market. In this episode, we explore why what works in Argentina won’t necessarily fly in Brazil or Mexico, and how companies are adapting to these unique regional dynamics. Join Dileep Thazhmon, Cofounder and CEO of Jeeves; Santiago Suarez, Cofounder and CEO of Addi; Gabriel Vasquez, a16z investment partner; and Angela Strange, a16z General Partner, as they discuss the future of fintech in LatAm and the unique approach required to succeed in this diverse market.​​Whether you're interested in the nuances of product development, the complexities of scaling across diverse markets, or the future of fintech in Latin America, this episode offers perspectives from industry leaders deeply invested in the region's tech ecosystem who believe the next big tech giants might just come from Latin America.Resources: Find Dileep on Twitter: https://x.com/thazhmonFind Santiago on Twitter: https://x.com/santiasuaFind Gabriel on Twitter: https://x.com/gevs94Find Angela on Twitter: https://x.com/astrangeStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode, we cover the recent data breach of nearly 3B records, including a significant number of social security numbers. Joining us to discuss are security experts Joel de la Garza and Naftali Harris. Incredibly enough, Naftali and his team were able to get their hands on the breached dataset and were able to validate the nature of the claims. Listen in as we explore the who, what, when, where, why… but also how a breach of this magnitude happens and what we can do about it.Resources:Read 16 Steps to Securing Your Data (and Life)Find Naftali on Twitter: https://x.com/naftaliharrisCheck out Sentilink: https://www.sentilink.com/Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This episode from Web3 with a16z Crypto, is all about innovation on a global scale, exploring both ecosystem and individual talent levels. We examine what works and what doesn’t, how certain regions evolve into startup hubs and economic powerhouses, and what constitutes entrepreneurial talent. We also discuss the nature of ambition, the journey to finding one’s path, and broader mindsets for navigating risk, reward, and dynamism across various regions, with a particular focus on London and Europe.Joining us is Matt Clifford, who played a pivotal role in the London entrepreneurial and tech ecosystem since 2011, is the Chair of Entrepreneur First and the UK’s Advanced Research and Invention Agency (ARIA). Before this episode was recorded, Matt served as the Prime Minister’s representative for the AI Safety Summit at Bletchley Park. Recently, he was appointed by the UK Secretary of Science to deliver an “AI Opportunities Action Plan” to the UK government.This episode was recorded live from Andreessen Horowitz’s first international office in London. For more on our efforts and additional content, visit a16zcrypto.com/uk. Resources:Find Matthew on Twitter: https://x.com/matthewcliffordFind Sonal on Twitter: https://x.com/smc90 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Once criticized for lacking ambition, French founders are now aiming to create the world’s largest companies. With a thriving ecosystem attracting talent from across Europe and the US, France is becoming a major player on the global stage.In this episode, we cover the unique advantages of building startups in France. Roxanne Varza, Director of Station F; Antoine Martin, co-founder of Amo and Zenly; and Brian Kim, a16z consumer partner, discuss the key factors driving this transformation, including infrastructure, community, and government support.Discover how international talent, a supportive community, and robust governmental backing are propelling France’s startup scene. This episode is filled with insights into why France is now an exciting place to build a startup.Resources:Find Roxanne on Twitter: https://x.com/roxannevarzaFind Antoine on Twitter: https://x.com/an21mFind Bryan on Twitter: https://x.com/kirbyman01Learn more about Station F: https://stationf.co/Learn more about Amo: https://get.amo.co/enStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Waymo's autonomous vehicles have driven over 20 million miles on public roads and billions more in simulation.In this episode, a16z General Partner David George sits down with Dmitri Dolgov, CTO at Waymo, to discuss the development of self-driving technology. Dmitri provides technical insights into the evolution of hardware and software, the impact of generative AI, and the safety standards that guide Waymo's innovations.This footage is from AI Revolution, an event that a16z recently hosted in San Francisco. Watch the full event here:  a16z.com/dmitri-dolgov-waymo-ai Resources: Find Dmitri on Twitter: https://x.com/dmitri_dolgovFind David George on Twitter: https://x.com/DavidGeorge83Learn more about Waymo: https://waymo.com/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The Olympics features over 11,000 athletes competing in 32 sports, attracting an audience of more than 10 million.In this episode, Charlie Ebersol, co-founder of the Alliance of American Football and Infinite Athlete, explores how new innovations like AI and bespoke broadcasting technologies are shaping the future of sports.Charlie also reflects on the storytelling legacy of his father, Dick Ebersol, a legendary sports producer who transformed how we experience the Olympics. We discuss the importance of making sports more accessible and engaging through technology that enhances, rather than distracts from, the human stories at the heart of the games.Whether you're a tech enthusiast or a sports fan, this episode offers a unique look at the convergence of these two worlds.Resources: Find Charlie on Twitter: https://x.com/CharlieEbersolLearn more more about Infinite Athlete: https://infiniteathlete.ai/Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

On June 27th, the a16z team headed to New York City for the first-ever AI Artist Retreat at their office. This event brought together the builders behind some of the most popular AI creative tools, along with 16 artists, filmmakers, and designers who are exploring the capabilities of AI in their work.In this episode, we hear from the innovators pushing the boundaries of AI creativity. Joined by Anish Acharya, General Partner, and Justine Moore, Partner on the Consumer team, we feature insights from:Ammaar Reshi - Head of Design, ElevenLabsJustin Maier - Cofounder & CEO, CivitaiMaxfield Hulker - Cofounder & COO, CivitaiDiego Rodriguez - Cofounder & CTO, KreaVictor Perez - Cofounder & CEO, KreaMohammad Norouzi - Cofounder & CEO, IdeogramHang Chu - Cofounder & CEO, ViggleConor Durkan - Cofounder, UdioThese leaders highlight the surprising commonalities between founders and artists, and the interdisciplinary nature of their work. The episode covers the origin stories behind these innovative tools, their viral moments, and their future visions. You'll also hear about the exciting potential for AI in various creative modalities, including image, video, music, 3D, and speech.Keep an eye out for more in our series highlighting the founders building groundbreaking foundation models and AI applications for video, audio, photography, animation, and more.Learn more and see videos on artists leveraging AI at: a16z.com/aiart Find Ammaar on Twitter: https://x.com/ammaarLearn more about ElevenLabs: https://elevenlabs.ioFind Justin on Twitter: https://x.com/justmaierFind Max on LinkedIn: https://www.linkedin.com/in/maxfield-hulker-5222aa230/Learn more about Civitai: https://civitai.comFind Diego on Twitter: https://x.com/asciidiego?lang=enFind Victor on Twitter: https://x.com/viccpoesLearn more about Krea: https://www.krea.ai/homeFind Mohammed on Twitter: https://x.com/mo_norouziLearn more about Ideogram: https://ideogram.ai/t/exploreFind Conor on Twitter: https://x.com/conormdurkanLearn more about Udio: https://www.udio.com/homeFind Hang on Twitter: https://x.com/chuhang1122Learn more about Viggle: https://viggle.ai/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Gaming is not just entertainment—it's a revolution reshaping our culture, technology, and economy. a16z’s Jonathan Lai and Andrew Chen dive into the current gaming renaissance and its future impact. Joining them are Michael Chow, CEO and Steven Snow, CPO of The Believer Company, and Eros Resmini, Founder and Managing Partner of The Mini Fund.They explore the intersection of tech, art, psychology, and design in gaming, discussing how startups can navigate intense competition, distribution challenges, and high production costs. With insights from these industry leaders, this episode covers the transformative potential of AI, the importance of player feedback, and strategies to stand out in a crowded market.Recorded during Speedrun, a16z’s extensive games accelerator, this episode offers a glimpse into the strategies and innovations driving the gaming industry forward. Resources: Find Steven on Twitter: https://twitter.com/StevenSnowFind Michael on LinkedIn: https://www.linkedin.com/in/believer-paladin/Find Eros on Twitter: https://twitter.com/erosresminiFind Jonathan on Twitter: https://twitter.com/TocelotFind Andrew on Twitter: https://twitter.com/andrewchenLearn more about Speedrun: https://a16z.com/games/speedrun/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Former gymnast and current investor Aly Raisman joins general partner Julie Yoo and investment partner Daisy Wolf of a16z Bio + Health.In this episode, Aly Raisman shares her quest for healthier living—physically, mentally, and financially—on her journey from gymnast to a business investor. Having transitioned from an intensely structured routine, Aly emphasizes the need for more open conversations about mental health and financial literacy. She speaks passionately about the gap in women’s health solutions and hopes to inspire entrepreneurs to create impactful businesses. Aly’s experiences as a patient, survivor, and global figure adds a unique dimension to her perspective as an investor. This candid conversation with Aly and Julie Yoo sheds light on Aly’s passion for more education within the investment space, offering invaluable insights for entrepreneurs, particularly in biotech and healthcare. Resources: Find Aly on Twitter: https://x.com/aly_raismanFind Julie on Twitter: https://x.com/julesyooFind Daisy on Twitter: https://x.com/daisydwolf Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Less than two years since the breakthrough of text-based AI, we now see incredible developments in multimodal AI models and their impact on millions of users.As part of New York Tech Week, we brought together a live audience and three leaders from standout companies delivering AI-driven products to millions. Gaurav Misra, Cofounder and CEO of Captions, Carles Reina, Chief Revenue Officer of ElevenLabs, and Laura Burkhauser, VP of Product at Descript discuss the challenges and opportunities of designing AI-driven products, solving real customer problems, and effective marketing.From the critical need for preventing AI misuse to ensuring international accessibility, they cover essential insights for the future of AI technology. Resources: Find Laura on Twitter: https://x.com/burkenstocksFind Carles on Twitter :https://twitter.com/carles_reinaFind Gaurav of Twitter: https://twitter.com/gmharhar Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

"The Ben & Marc Show," featuring a16z co-founders Marc Andreessen and Ben Horowitz. In this special episode, Marc and Ben dive deep into the REAL story behind the creation of Netscape—a web browser co-created by Marc that revolutionized the internet and changed the world. As Ben notes at the top, until today, this story has never been fully told either in its entirety or accurately. In this one-on-one conversation, Marc and Ben discuss Marc's early life and how it shaped his journey into technology, the pivotal moments at the University of Illinois that led to the development of Mosaic (a renegade browser that Marc developed as an undergrad), and the fierce competition and legal battles that ensued as Netscape rose to prominence. Ben and Marc also reflect on the broader implications of Netscape's success, the importance of an open internet, and the lessons learned that still resonate in today's tech landscape (especially with AI). That and much more. Enjoy!Watch the FULL Episode on YouTune: https://youtu.be/8aTjA_bGZO4 Resources: Marc on X: https://twitter.com/pmarca Marc’s Substack: https://pmarca.substack.com/ Ben on X: https://twitter.com/bhorowitz Book mentioned on this episode: - “Expert Political Judgment” by Philip E. Tetlock https://bit.ly/45KzP6M TV Series mentioned on this episode: - “The Mandalorian” (Disney+) https://bit.ly/3W0Zyoq Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

We know that technology has changed art, and that artists have evolved with every new technology — it’s a tale as old as humanity, moving from cave paintings to computers. Underlying these movements are endless debates around inventing versus remixing; between commercialism and art; between mainstream canon and fringe art; whether we’re living in an artistic monoculture now (the answer may surprise you); and much much more. So in this new episode featuring Berlin-based contemporary artist Simon Denny -- in conversation with a16z crypto editor in chief Sonal Chokshi -- we discuss all of the above debates. We also cover how artists experimented with the emergence of new technology platforms like the web browser, the iPhone, Instagram and social media; to how generative art found its “native” medium on blockchains, why NFTs; and other art movements. Denny also thinks of entrepreneurial ideas -- from Peter Thiel's to Chris Dixon's Read Write Own -- as an "aesthetic"; and thinks of technology artifacts (like NSA sketches!) as art -- reflecting all of these in his works across various mediums and contexts. How has technology changed art, and more importantly, how have artists changed with technology? How does art change our place in the world, or span beyond space? It's about optimism, and seeing things anew... all this and more in this episode. Resources: Find Denny on Twitter: https://x.com/dennnnnnnnnyFind Sonal on Twitter: https://x.com/smc90 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Is it time to hand over cybersecurity to machines amidst the exponential rise in cyber threats and breaches?We trace the evolution of cybersecurity from minimal measures in 1995 to today's overwhelmed DevSecOps. Travis McPeak, CEO and Co-founder of Resourcely, kicks off our discussion by discussing the historical shifts in the industry. Kevin Tian, CEO and Founder of Doppel, highlights the rise of AI-driven threats and deepfake campaigns. Feross Aboukhadijeh, CEO and Founder of Socket, provides insights into sophisticated attacks like the XZ Utils incident. Andrej Safundzic, CEO and Founder of Lumos, discusses the future of autonomous security systems and their impact on startups.Recorded at a16z's Campfire Sessions, these top security experts share the real challenges they face and emphasize the need for a new approach. Resources: Find Travis McPeak on Twitter: https://x.com/travismcpeakFind Kevin Tian on Twitter: https://twitter.com/kevintian00Find Feross Aboukhadijeh on Twitter: https://x.com/ferossFind Andrej Safundzic on Twitter: https://x.com/andrejsafundzic Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Brooke Boyarsky Pratt, founder and CEO of knownwell, joins Vineeta Agarwala, general partner at a16z Bio + Health.Together, they talk about the value of obesity medicine practitioners, patient-centric medical homes, and how Brooke believes the metabolic health space will evolve over time.This is the second episode in Raising Health’s series on the science and supply of GLP-1s. Listen to last week's episode to hear from Carolyn Jasik, Chief Medical Officer at Omada Health, on GLP-1s from a clinical perspective. Listen to more from Raising Health’s series on GLP-1s:The science of satiety: https://raisinghealth.simplecast.com/episodes/the-science-and-supply-of-glp-1s-with-carolyn-jasikPayers, providers and pricing: https://raisinghealth.simplecast.com/episodes/the-science-and-supply-of-glp-1s-with-chronis-manolis Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this latest episode on the State of AI, Ben and Marc discuss how small AI startups can compete with Big Tech’s massive compute and data scale advantages, reveal why data is overrated as a sellable asset, and unpack all the ways the AI boom compares to the internet boom. Subscribe to the Ben & Marc podcast: https://link.chtbl.com/benandmarc Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Over the past decade, usage-based pricing has soared in popularity. Why? Because it aligns cost with value, letting customers pay only for what they use. But, that flexibility is not without issues - especially when it comes to predicting revenue. Fortunately, with the right process and infrastructure, your usage-based revenue can become more predictable than the traditional seat-based SaaS model. In this episode from the a16z Growth team, Fivetran’s VP of Strategy and Operations Travis Ferber and Alchemy’s Head of Sales Dan Burrill join a16z Growth’s Revenue Operations Partner Mark Regan. Together, they discuss the art of generating reliable usage-based revenue. They share tips for avoiding common pitfalls when implementing this pricing model - including how to nail sales forecasting, adopting the best tools to track usage, and deal with the initial lack of customer data. Resources: Learn more about pricing, packaging, and monetization strategies: a16z.com/pricing-packagingFind Dan on Twitter: https://twitter.com/BurrillDanielFind Travis on LinkedIn: https://www.linkedin.com/in/travisferberFind Mark on LinkedIn: https://www.linkedin.com/in/mregan178Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

On May 21, the California Senate passed bill 1047.This bill – which sets out to regulate AI at the model level – wasn’t garnering much attention, until it slid through an overwhelming bipartisan vote of 32 to 1 and is now queued for an assembly vote in August that would cement it into law. In this episode, a16z General Partner Anjney Midha and Venture Editor Derrick Harris breakdown everything the tech community needs to know about SB-1047.This bill really is the tip of the iceberg, with over 600 new pieces of AI legislation swirling in the United States. So if you care about one of the most important technologies of our generation and America’s ability to continue leading the charge here, we encourage you to read the bill and spread the word.Read the bill: https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202320240SB1047

Consumer AI is moving fast, so who's leading the charge? a16z Consumer Partners Olivia Moore and Bryan Kim discuss our GenAI 100 list and what it takes for an AI model to stand out and dominate the market.They discuss how these cutting-edge apps are connecting with their users and debate whether traditional strategies like paid acquisition and network effects are still effective. We're going beyond rankings to explore pivotal benchmarks like D7 retention and introduce metrics that define today's AI market.Note: This episode was recorded prior to OpenAI's Spring update. Catch our latest insights in the previous episode to stay ahead! Resources:Link to the Gen AI 100: https://a16z.com/100-gen-ai-appsFind Bryan on Twitter: https://twitter.com/kirbyman01Find Olivia on Twitter: https://x.com/omooretweets Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

a16z General Partner David Haber talks with Marty Chavez, vice chairman and partner at Sixth Street Partners, about the foundational role he’s had in merging technology and finance throughout his career, and the magical promises and regulatory pitfalls of AI.This episode is taken from “In the Vault”, a new audio podcast series by the a16z Fintech team. Each episode features the most influential figures in financial services to explore key trends impacting the industry and the pressing innovations that will shape our future.  Resources: Listen to more of In the Vault: https://a16z.com/podcasts/a16z-liveFind Marty on X: https://twitter.com/rmartinchavezFind David on X: https://twitter.com/dhaber Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This was a big week in the world of AI, with both OpenAI and Google dropping significant updates. So big that we decided to break things down in a new format with our Consumer partners Bryan Kim and Justine Moore. We discuss the multi-modal companions that have found their voice, but also why not all audio is the same, and why several nuances like speed and personality really matter. Resources:OpenAI’s Spring announcement: https://openai.com/index/hello-gpt-4o/Google I/O announcements: https://blog.google/technology/ai/google-io-2024-100-announcements/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Make sure to check out our new AI + a16z feed: https://link.chtbl.com/aiplusa16z a16z General Partner Anjney Midha joins the podcast to discuss what's happening with hardware for artificial intelligence. Nvidia might have cornered the market on training workloads for now, but he believes there's a big opportunity at the inference layer — especially for wearable or similar devices that can become a natural part of our everyday interactions. Here's one small passage that speaks to his larger thesis on where we're heading:"I think why we're seeing so many developers flock to Ollama is because there is a lot of demand from consumers to interact with language models in private ways. And that means that they're going to have to figure out how to get the models to run locally without ever leaving without ever the user's context, and data leaving the user's device. And that's going to result, I think, in a renaissance of new kinds of chips that are capable of handling massive workloads of inference on device."We are yet to see those unlocked, but the good news is that open source models are phenomenal at unlocking efficiency.  The open source language model ecosystem is just so ravenous."More from Anjney:The Quest for AGI: Q*, Self-Play, and Synthetic DataMaking the Most of Open Source AISafety in Numbers: Keeping AI OpenInvesting in Luma AIFollow everyone on X:Anjney MidhaDerrick HarrisCheck out everything a16z is doing with artificial intelligence here, including articles, projects, and more podcasts. Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 2009 Discord cofounder and CEO, Jason Citron, started building tools and infrastructure for games. Fast forward to today and the platform has over 200 million monthly active users. In this episode, Jason, alongside a16z General Partner Anjney Midha—who merged his company Ubiquity6 with Discord in 2021—shares insights on the nuances of community-driven product development, the shift from gamer to developer, and Discord’s longstanding commitment to platform extensibility. Now, with Discord's recent release of embeddable apps, what can we expect now that it's easier than ever for developers to build? Resources: Find Jason on Twitter: https://twitter.com/jasoncitronFind Anjney on Twitter: https://twitter.com/AnjneyMidha Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Human nature fears the unknown, and with the rapid progress of AI, concerns naturally arise. Uncanny robocalls, data breaches, and misinformation floods are among the worries. But what about security in the era of large language models?In this episode, we hear from security leaders at OpenAI, Anthropic, and Google DeepMind. Matt Knight, Head of Security at OpenAI, Jason Clinton, CISO at Anthropic, and Vijay Bolina, CISO at Google DeepMind, are joined by Joel de la Garza, operating partner at a16z and former chief security officer at Box and Citigroup.Together, they explore how large language models impact security, including changes in offense and defense strategies, misuse by nation-state actors, prompt engineering, and more. In this changing environment, how do LLMs transform security dynamics? Let's uncover the answers. Resources:Find Joel on LinkedIn: https://www.linkedin.com/in/3448827723723234/Find Vijay Bolina on Twitter: https://twitter.com/vijaybolinaFind Jason Clinton on Twitter: https://twitter.com/JasonDClintonFind Matt Knight  on Twitter: https://twitter.com/embeddedsec Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In recent years, the AI landscape has seen huge advancements, from the release of Dall-E 2 in April 2022 to the emergence of AI music and video models in early 2024.While creative tools often steal the spotlight, AlphaFold 2 marked a groundbreaking AI breakthrough in biology in 2021. Since its release, this pioneering tool for predicting protein structures has been utilized by over 1.7 million scientists worldwide, influencing fields ranging from genomics to computational chemistry.In this episode, DeepMind's VP of Research for Science, Pushmeet Kohli, and a16z General Partner Vijay Pande discuss the transformative potential of AI in scientific exploration. Can AI lead to fundamentally new discoveries in science? Let's find out. Resources: Find Pushmeet on Twitter: https://twitter.com/pushmeetFind Vijay on Twitter: https://twitter.com/vijaypandeLearn more about Google DeepMind: https://deepmind.googleRead DeepMind’s AlphaFold whitepaper: https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafoldRead DeepMind’s AlphaGeometry: https://deepmind.google/discover/blog/alphageometry-an-olympiad-level-ai-system-for-geometryRead DeepMind’s research on new materials: https://deepmind.google/discover/blog/millions-of-new-materials-discovered-with-deep-learning/Read DeepMind’s paper on FunSearch, focused on new discoveries in mathematics: https://deepmind.google/discover/blog/funsearch-making-new-discoveries-in-mathematical-sciences-using-large-language-models Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Over 3,700 companies applied to a16z’s SPEEDRUN. In this episode, we meet the founders pushing the boundaries of what games can be.From the fusion of traditional gaming elements with modern tech-twists, a16z General Partner Andrew Chen and Partner Josh Lu discuss the challenges and wins of creating games that are not only fun but also integrate seamlessly into the digital age, from AI-twins to games that “move at the speed of culture”. Whether you’re a developer, an enthusiast, or just curious about the future of interactive entertainment, this episode provides a glimpse into how today's creators use creativity and technology to captivate.If you're passionate about shaping the future of gaming, consider applying for SPEEDRUN 3.0 at a16z.com/speedrun3. Resources: Submit your SPEEDRUN 3.0 application: https://a16z.com/speedrun-la-2024Find Andrew on Twitter: https://twitter.com/andrewchenFind Josh on Twitter: https://twitter.com/JoshLuLearn more about Avi and Magic Circle: https://twitter.com/aviromanoffLearn more about Lil Snack: https://www.lilsnack.coLearn more about Neon Wild: https://www.neonwild.comLearn more about Open Souls: https://www.opensouls.studioLearn more about Altera: https://altera.al Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Senator Todd Young (R-IN) speaks with a16z General Partner Martin Casado about the importance of open innovation and American leadership in AI, and why we need to support AI research at all levels — from the classroom to the war room.In this episode, we distinguish science fiction from science reality in the ever-evolving AI landscape. Resources:Find Senator Todd Young on Twitter: https://twitter.com/toddyounginFind Martin Casado on Twitter: https://twitter.com/martin_casadoWatch the American Dynamism stage talks on YouTube: https://bit.ly/3IqWn1WTo learn more about the American Dynamism Summit, visit our website: a16z.com/ad-summit Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The gaming industry stands as a pioneer of cutting-edge technologies, ushering in innovations like GPUs, virtual and augmented reality, physics engines, and immersive multiplayer experiences. In this episode, a16z cofounder Marc Andreessen and Andrew Chen, General Partner at a16z Games, dig into why a16z was compelled to establish a dedicated games fund. They explore the origins of tech pessimism, effective engagement with government in tech, its significance for the gaming community, the ongoing AI revolution, and even what Marc himself would build today if he didn't have his hands full. Recorded as part of a16z's extensive games fund accelerator, SPEEDRUN, this session offers valuable insights for founders and innovators at the intersection of games and technology. If you're passionate about shaping the future of gaming, consider applying for SPEEDRUN 3.0 at a16z.com/speedrun3. Resources: Find Marc on Twitter: https://twitter.com/pmarcaFind Andrew on Twitter: https://twitter.com/andrewchenSubmit your SPEEDRUN 3.0 application: https://a16z.com/speedrun-la-2024 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

From air-defining radar and electronic systems that helped the Allies win World War II, the origins of Silicon Valley are deeply rooted in government and defense.In today's episode, we get the chance to revisit that relationship with the United States Deputy Secretary of Defense, Kathleen Hicks.Deputy Secretary Hicks has spent decades of her career focused on defense policy and in her keynote address from a16z's second annual American Dynamism Summit in Washington, D.C., you'll get an inside look into the priorities of the DoD and how it views its past, present, and future.In the second half of the episode, you’ll hear highlights from Deputy Secretary Hicks' fireside chat with Wall Street Journal’s National Security Editor, Sharon Weinberger, where they dive into the numerous issues facing our country today, from Ukraine to the use of AI on the battlefield. Resources: Find Deputy Secretary Hicks on Twitter: https://twitter.com/depsecdefFind Sharon on Twitter: https://twitter.com/weinbergersaTo learn more about the American Dynamism Summit: www.a16z.com/ad-summitVisit the full playlist of American Dynamism Summit videos on YouTube: https://bit.ly/3IqWn1W Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

“If America is going to be America in the next one hundred years, we have to get this right.” - Ben HorowitzThis week on “The Ben & Marc Show”, a16z co-founders Ben Horowitz and Marc Andreessen take on one of the most hot button issues facing technology today: tech regulation and policy.In this one-on-one conversation, Ben and Marc delve into why the political interests of “Big Tech” conflict with a positive technological future, the necessity of decentralized AI, and how the future of American innovation is at its most critical point. They also answer YOUR questions from X (formerly Twitter). That and much more. Enjoy! Resources:Watch full episode: https://youtu.be/dX7d6bRJI9kMarc on X: https://twitter.com/pmarcaMarc’s Substack: https://pmarca.substack.comBen on X: https://twitter.com/bhorowitzBen’s Article: “Politics and the Future” bit.ly/3PGKrgw Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

From judging inventions on “Shark Tank” to reshaping the image of NBA ownership, Mark Cuban is known for many things. In this chat with a16z General Partner David Ulevitch, he discusses the importance of entrepreneurship for maintaining America’s status as the most innovative place on the planet. This includes making big bets, like he’s doing with Cost Plus Drugs, his latest venture that seeks to upend the prescription drug markets. Resources: Find Mark on Twitter: https://twitter.com/mcubanFind David Ulevitch on Twitter: https://twitter.com/daviduLearn more about the American Dynamism Summit: www.a16z.com/ad-summit Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

At the a16z LP Summit, we brought hundreds of our limited partners and portfolio founders together in Las Vegas.The event was truly overflowing with stories of how founders are challenging the status quo and harnessing technology to make the world a better place. Amidst these stories, it became clear that in the realms of public safety and healthcare, the stakes couldn't be higher—these sectors not only hold lives in balance but also stand as fertile ground for technological breakthroughs.In this episode, a16z General Partner Vijay Pande chats with Ed and Todd Park, the visionary siblings behind Devoted Health. Their mission? To overhaul a healthcare system they describe as critically essential yet deeply flawed. The Park brothers delve into the genesis of their ambition to construct a healthcare system from scratch, underscoring the sector's urgent need for technological innovation and the game-changing role of AI.Kicking off with an American dream story, this episode is a must-listen for anyone interested in how technology can reshape healthcare for the better. Resources: Find Vijay on Twitter: https://twitter.com/vijaypandeFind Ed on Twitter: https://twitter.com/edparkdevotedFind Todd on LinkedIn: https://www.linkedin.com/in/todd-park-3232573Learn more about Devoted Health: https://www.devoted.com Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Generative AI has initiated a transformative shift, reshaping our world in unprecedented ways. In a16z's AI Revolution series, we engage some of the most impactful builders in the field of AI discussing and debating where we are, where we’re going, and the big open questions in AI.In this episode, General Partner David George chats with Adam D'Angelo, the CEO and founder of Quora, wade into this fast-moving AI landscape, and specifically touch on how building infrastructure for creators can democratize AI. Adam, who is now building AI aggregator Poe and is on the board of OpenAI, has long been paying attention to this AI wave. He recounts this evolving fascination, and together Adam and David explore the dynamic synergy between humans and AI, highlighting the critical role of experimentation for founders in the AI realm.As a reminder, this conversation comes from our AI Revolution series, which you can dive into more deeply at a16z.com/ai.  Resources:Watch the the full interview: www.a16z.com/AIRevolutionFind Adam on Twitter: https://twitter.com/adamdangeloFind David George on Twitter: https://twitter.com/DavidGeorge83 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Nuclear energy accounts for 20% of the electricity in the United States, but remarkably, 2023 marked the commissioning of the U.S.'s first new nuclear reactor in over three decades. The past few years have been a story of changing public opinion, but equally, innovative startups crafting groundbreaking reactor designs and an ambitious announcement by the U.S. government to triple nuclear power production by 2050.In this episode recorded at a16z’s American Dynamism Summit in Washington DC, a16z podcast host Steph Smith is joined by a16z General Partner David Ulevich, Doug Bernauer – CEO of microreactor company Radiant – and Dr. Kathryn Huff, Assistant Secretary of the Office of Nuclear Energy.From energizing the country's data centers to propelling the electric vehicles on our roads or powering the factories crafting tomorrow's innovations, they discuss why expanding our nuclear capacity is a national imperative. Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington DC. Topics Covered: 00:00 - The Promise of Advanced Nuclear Reactors03:43 - Nuclear Energy's Current Landscape07:00 - Vulnerabilities in Fuel Delivery10:30 - Nuclear Energy's Timeline12:11 - Portable Microreactors and Mass Production 15:06 - Nuclear Energy's Role in America21: 24 - Government's Role in Nuclear Energy26:08 - Challenges of Portable Micro Reactors 30:03- The Evolution of Nuclear Reactors32:11 - Nuclear’s Public Perception and Safety39:21 - The Global Need for Nuclear Power Resources:Learn more about American Dynamism Summit 2024: www.a16z.com/adsummitFind Dr. Kathryn Huff on Twitter: https://twitter.com/katyhuffFind Doug Bernauer and Radiant on Twitter: https://twitter.com/radiantnuclearFind David Ulevitch on Twitter: https://twitter.com/davidu Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Artificial intelligence has taken the world by storm. But despite the hype around personalized avatars or podcast language translation, artificial intelligence is not only impacting the creative spheres; in fact it’s hard to find an industry that isn’t being touched by this technology – and defense of our country is far from excluded.In this episode, originally recorded in the heart of Washington DC this January during a16z’s American Dynamism Summit, a16z General Partner Martin Casado and a16z enterprise editor, Derrick Harris are joined by the first-ever CTO of the CIA, Nand Mulchandani.In this wide-ranging conversation, they discuss the evolving relationship between analysts and AI, how governments can keep up with this exponential technology, and finally, how it’s impacting both offense and defense.  This episode is essential listening for anyone interested in the intersection of technology, national security, and policy-making in the age of artificial intelligence. Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington DC. Topics Covered:00:00 - Intelligence in the Age of AI02:28 - Rethinking Jobs and AI's Asymmetric Power05:00 - The History of AI in the Intelligence Community07:00 - Operational Utilization of AI10:40 - Analytic Capabilities and Uncertainty12:56 - AI's 'Hallucination' Concerns16:37 - Analyst Skill Sets and AI Tools26:29 - Supply Chain and Open Source31:35 - Public-Private Partnerships41:33 - Government as a Customer and Partner in Tech42:43 - Policy, Technology, and Regulation ResourcesLearn more about AD Summit 2024: www.a16z.com/adsummitWatch all of the stage talks at AD Summit 2024: https://www.youtube.com/playlist?list=PLM4u6XbiXf5pAKmk1AeZ9964KGScf4lHMRead the CIA’s announcement around the new CTO role: https://www.cia.gov/stories/story/cia-names-first-chief-technology-officer/Find Nand Mulchandani on Twitter: https://twitter.com/nandmulchandaniFind Martin on Twitter: https://twitter.com/martin_casadoFind Derrick on Twitter: https://twitter.com/derrickharris Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The last few decades have been a period of transition for defense. An increasing number of startups have begun to rival large defense primes, the industry has gradually become a calculus of both hardware and software, and exponential technologies have forced the DoD to rethink how it has  traditionally done business.These changing conditions were some of the inputs to resulting in the DIU – Defense Innovation Unit – starting in 2015 within the Department of Defense, focused on accelerating the adoption of technology.In this episode recorded at a16z’s American Dynamism Summit in January, a16z General Partner Katherine Boyle is joined by the Director of the DIU, Doug Beck, plus two critical founders ushering in this new era of defense: Brian Schimpf, cofounder and CEO of Anduril and Brandon Tseng, cofounder of Shield AI.So what does the next wave of defense innovation really look like? Let’s find out. 00:00 - The Future of Defense Innovation 03:30 - The Defense Innovation Unit (DIU)05:45 - Adoption of Startup tech by the DoD07:42 - Acquisition, Budgeting, and Contracting13:17 - Traditional Primes vs Startups14:25 - Cost-Plus Fixed Fee Contracts20:11 - The Replicator Program22:26 - The New Threat Environment27:11 - Scale and Readiness for Modern Warfare32:15 - Procurement Reform and Feasibility39:30 - Success Metrics for Defense Resources:Learn more about AD Summit 2024: www.a16z.com/adsummitWatch Brian’s stage talk at AD Summit 2024: https://a16z.com/securing-americas-future-how-technology-companies-and-washington-are-building-a-safer-world/Watch all of the stage talks at AD Summit 2024: https://www.youtube.com/playlist?list=PLM4u6XbiXf5pAKmk1AeZ9964KGScf4lHMFind Katherine on Twitter: https://twitter.com/KTmBoyleFind Brandon and Shield AI on Twitter: https://twitter.com/shieldaitechFind Brian on Twitter: https://twitter.com/schimpfbrianFind Doug and the DIU on Twitter: https://twitter.com/diu_x Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

American Dynamism. A term coined by a16z General Partner, Katherine Boyle, two years ago, when she and David Ulevitch founded the firm's American Dynamism investing practice.Beyond a sector or movement, American Dynamism embodies innovation, community, and a unique philosophy touching every facet of American life.In this episode, we hear from 10 voices, including policymakers, founders, and funders, as they share what American Dynamism means to them. They discuss the critical technologies shaping the future and the challenges on the path to the next decade of dynamism. Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington, D.C. Resources: Find Dr. Kathryn Huff on Twitter: https://twitter.com/katyhuffFind Nand Mulchandani on Twitter: https://twitter.com/nandmulchandaniFind Doug Beck and the DIU on Twitter: https://twitter.com/diu_xFind Mitch Lee on Twitter: https://twitter.com/dontmitchFind Ian Cinnamon on Twitter: https://twitter.com/IanCinnamonFind Doug Bernauer and Radiant on Twitter: https://twitter.com/radiantnuclearFind Chris Bennett on Twitter: https://twitter.com/8ennettFind Mike Slagh on Twitter: https://twitter.com/MikeSlaghFind Rahul Sidhu on Twitter: https://twitter.com/rahoolsidooFind Wyatt Smith on Twitter: https://twitter.com/wyatt_h_smithLearn more about American Dynamism: https://a16z.com/american-dynamism Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

You might recognize the name Mark Pincus but we almost guarantee you recognize the game Farmville. Mark Pincus is the founder and longtime CEO of Zynga, known for its massive global franchise of games, including those household names like Farmville and Words with Friends. Zynga was also at the forefront of the transition to mobile and the use of large platforms like Facebook for distribution.In this episode Mark joins Josh Lu from the a16z Games team for a fireside chat. They discuss navigating major tech waves and recognizing "true signal" opportunities, and explore a wide range of topics, from the strategic insights that propelled Zynga to success, the future of the Metaverse, and the philosophy behind minimum viable products. This conversation offers invaluable insights for both gaming industry insiders and enthusiasts looking to understand the dynamics of tech innovation and entrepreneurship.Topics Covered:00:00 - How Zynga Spotted the Mobile Wave02:47 - Challenges of Starting Zynga05:24 - Zynga's Early Workforce and Learning HTML07:40 - Preparing for Tech Waves11:29 - The Importance of Being Too Early15:42 - The attribute of great founders18:33 - Hiring Philosophy 22:02 - ‘Everyone is  a CEO’24:20 - Fast Iteration and Learning from Failures31:06 - Personal Gaming Preferences32:52 - Advice on Reevaluating Projects and True Signal35:50 - AI's Role in Consumer Adoption and Gaming40:17 - Community as a Core Element43:31 - UGC Gaming Space and Future Computing ParadigmsResources: Find Mark on Twitter: https://twitter.com/markpincFind Josh on Twitter: https://twitter.com/joshluLearn more about SPEEDRUN 3.0: https://a16z.com/speedrun3Learn more about SPEEDRUN: ttps://a16z.com/speedrun-your-gaming-startupStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In early 2024, the notion of high fidelity, believable AI-generated video seemed a distant future to many. Yet, a mere few weeks into the year, OpenAI unveiled Sora, its new state of the art text-to-video model producing videos of up to 60 seconds. The output shattered expectations – even for other builders and researchers within generative AI – sparking widespread speculation and awe.How does Sora achieve such realism? And are explicit 3D modeling techniques or game engines at play?In this episode of the a16z Podcast, a16z General Partner Anjney Midha connects with Stefano Ermon, Professor of Computer Science at Stanford and key figure at the lab behind the diffusion models now used in Sora, ChatGPT, and Midjourney. Together, they delve into the challenges of video generation, the cutting-edge mechanics of Sora, and what this all could mean for the road ahead.Resources: Find Stefano on Twitter: https://twitter.com/stefanoermonFind Anjney on Twitter: https://twitter.com/anjneymidhaLearn more about Stefano’s Deep Generative Models course: :https://deepgenerativemodels.github.ioStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The electric grid needs an update. In this explainer, a16z Partner Ryan McEntush discusses the escalating complexity of the grid, unveils its vulnerabilities, and traces the evolutionary path that has led us to this point. From the surging demands of AI to outdated infrastructure, we delve into the potential roles of cutting-edge technologies such as solar batteries, natural gas, and nuclear power in shaping the grid's future.Timestamps:(00:00) - Introduction(02:28) - The Need for Grid Modernization(04:43) - Understanding the Grid's Operation and Challenges(06:47) - The Complexity of Grid Management(08:31) - Increasing Outages and Volatility(11:49) - The Role of New Technologies(17:53) - The Potential and Limitations of Renewable Energy Sources(19:08) - Energy Storage Solutions(24:57) - The Future of Natural Gas and Nuclear Power(29:46) - The Impact of Policy on the Grid(31:47) - The Concept of a Smart Grid(34:04) - Decentralization of the Grid(36:57) - The Role of the Free Market in Grid ReliabilityResources: Find Ryan on Twitter: https://twitter.com/rmcentushRead Ryan’s latest articles: https://a16z.com/author/ryan-mcentushStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

"The Ben & Marc Show" features a16z's co-founders Ben Horowitz & Marc Andreessen. In this episode, Marc and Ben continue their in-depth exploration of the current education system. While Part I of their discussion unpacked the crisis facing higher education, Part II presents solutions to overhaul the modern university.In this one-on-one conversation, Ben and Marc delve into actions that existing institutions can take to improve their current and future situations. This includes exploring new methods for talent recruitment, providing a more individualized education experience for students, and reducing administrative bloat. They also apply an entrepreneurial lens to each university function, revealing startup opportunities poised to emerge – including the building of brand new institutions, nonprofits, and research entities. Enjoy!Resources:*Watch Part I: https://youtu.be/7J2_G4oHRQ0*Watch Part II: https://youtu.be/EeIdalo2huIMarc on X: https://twitter.com/pmarcaMarc’s Substack: https://pmarca.substack.com/Ben on X: https://twitter.com/bhorowitz“South Park” episode mentioned in this discussion: – Eps 1505 (stream on Max): https://bit.ly/3HrZQg0Stay Updated:Find us on X: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16z

with @cdixon @rhhackettWelcome to the web3 with a16z crypto podcast. I'm Robert Hackett, an editor here at a16z crypto, and I'm here with Chris Dixon, founding partner of a16z crypto and author of the new book Read Write Own: Building the Next Era of the Internet.  I had the privilege of editing Chris throughout the book writing process, and I'm thrilled now to talk to you about what went on behind the scenes, the big themes of the book, the challenges, and also about the crypto industry at large as well as what we can expect from it in the future.Learn more at https://readwriteown.com/.Resources for references in this episode:Black Swan by Nassim Nicholas TalebThe Tipping Point by Malcolm GladwellSpider-Man: Across the Spider-verse"'It's a canon event' TikTok trend, explained"Chris Dixon's blog at cdixon.org"Come for the tool, stay for the network""The next big thing starts out looking like a toy""Can't be evil"The Cold Start Problem by Andrew ChenOn Andrew Chen's writing habitsOn investing in Coinbase in 2013Guidance from the U.S. Securities & Exchange Commission in 2019: "Framework for 'Investment Contract' Analysis of Digital Assets"On blockchains as "a programmable computer that lives in the sky" via a16z crypto head of research Tim RoughgardenGödel Escher Bach by Douglas Hofstader"How Aristotle Created the Computer" by Chris Dixon for The Atlantic"A Symbolic Analysis of Relay and Switching Circuits" by Claude ShannonPrincipia Mathematica by Bertrand Russell and Alfred North WhiteheadAn Investigation of the Laws of Thought by George BooleThe End of Education by Neil Postman"Inside out vs. outside in: The adoption of new technologies" by Chris Dixon"The Inevitable Showdown Between Twitter and Twitter Apps" by Chris Dixon"Elon Musk says X is discouraging links in posts" by Sara Fischer"Make Ethereum Cypherpunk Again" by Vitalik Buterin"What Will Happen in 2024" by Fred Wilson"A Logical Calculus of the Ideas Immanent in Nervous Activity" by McCullough and PittsCrossing the Chasm by Geoffrey A. MooreOn "thesis, antithesis, and synthesis" and Hegel's DialecticsAs a reminder, none of the following should be taken as business, legal, tax, or investment advice; please see a16z.com/disclosures for more important information, including a link to a list of our investments.

In 2022 and 2023, US IPOs hit decade lows after the record high of 2021. Now, in 2024, will the IPO window reopen?In this episode, we revisit a conversation with Jeff Jordan, former CEO of OpenTable, and J.D. Moriarty, the former Head Managing Director and Head of Equity Capital Markets at Bank of America Merrill Lynch.Joined by Sonal Choksi, the pair takes you behind the scenes to unravel the complexities surrounding IPOs, including pricing, allocations, and the elusive "pop." They also discuss OpenTable’s IPO, which occurred immediately following the worst financial crisis since the Great Depression, and weigh in on the question: Can you time an IPO in an unpredictable year? Resources:Find Jeff on Twitter: https://twitter.com/jeff_jordanFind J.D on LinkedIn: https://www.linkedin.com/in/jdmoriartyFind Sonal on Twitter: https://twitter.com/smc90 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

(00:00) - The Future of Jobs(03:15) - Job growth over the last 80 years(05:06) - The shelf-life of jobs(09:11) - Education trends(12:25) - The importance of learning the foundations(17:18) - Regional access to education(20:19) - How companies are hiring and looking at strategic priorities(22:58) - The economic mobility and economic stability of degrees (25:59) - Job and training trends at Grow with Google(28:11) - Do companies train or hire for skills?(29:23) - The future of the traditional degree(31:10) - The employer and educator ecosystem (35:36) - How to approach upskilling  In a world where technology is moving at an unprecedented pace, what will the jobs of the future look like?Kai Roemmelt, CEO of the online learning platform Udacity, and Lisa Gevelber, a key figure at Google responsible for building the Grow with Google program, unpack the seismic changes reshaping the tech and education realms.From disrupting hiring norms to redefining how we acquire degrees and engage globally, this episode poses the question: How can you skillfully navigate the challenges and seize the opportunities awaiting in this evolving landscape?Resources: Find Kai on LinkedIn: https://www.linkedin.com/in/kai-roemmeltFind Lisa on LinkedIn: https://www.linkedin.com/in/lisagevelberLearn more about Udacity: https://www.udacity.comLearn more about Grow with Google: https://grow.googleStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Big news from a16z: Bio Eats World, our sibling show from a16z Bio+Health, is now Raising Health!We’re excited to share Raising Health’s first episode here where Sean Duffy, cofounder and CEO of Omada Health, joins Vijay Pande, founding general partner of Bio + Health.Sean and Vijay discuss the building and growth of Omada, from the early days to now. As the cofounder of one of the original digital health companies, Sean has unique insight into the growth of both the digital health field and the changing venture capital environment. They also talk about the future of AI, how Omada is leveraging AI, and the challenges that might arise with using a technology in a caregiving environment.You can listen to more episodes of Raising Health here: https://link.chtbl.com/IqBoJ2By?sid=a16z11824

In this one-on-one conversation, Marc and Ben tackle the university system – what has certainly been a hot topic that’s been dominating the news over the past few months. As Marc states at the top of the episode, universities matter tremendously to our world, but they’re currently in a state of crisis.Together, Ben and Marc take a “structural” look at higher education, delving deep into the twelve functions of the modern university.  They also unpack the numerous challenges that universities face today – student debt and the replication crisis, among them. They also discuss topics including DEI, student athlete admissions, accreditation, inflation, and much more. As colleges face an existential threat that could have long lasting repercussions, how can we find ways to improve these institutions, while being open to new entrepreneurial opportunities in education?Check out the Ben and Marc show: https://link.chtbl.com/benandmarc Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Flock is a public safety technology platform that operates in over 4,000 cities across the United States, and solves about 2,200 crimes daily. That’s 10 percent of reported crimes nationwide.Taken from a16z’s recent LP Summit, a16z General Partner David Ulevitch  joins forces with Flock Safety’s founder, Garrett Langley and Sheriff Kevin McMahill of the Las Vegas Metropolitan Police Department. Together, they cover the delicate balance between using technology to combat crime and respecting individual privacy, and explore the use of drones and facial recognition, building trust within communities, and the essence of objective policing. Resources: Find Garret on Twitter: https://twitter.com/glangleyFind Sheriff McMahill on Twitter:  https://twitter.com/Sheriff_LVMPDFind David on Twitter:https://twitter.com/daviduLearn more about Flock Safety: https://www.flocksafety.com Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Nature’s blueprint – DNA – is an incredibly efficient machine. You cannot see it with the naked eye, yet it can last for hundreds, maybe even millions of years. Plus, the storage capacity of a single gram of DNA is over 200 million gigabytes! As the cost of DNA sequencing (reading) and synthesis (writing) comes down, scientists are looking to our very own biology for applications reaching as far as data storage. Learn more about this fascinating world with a16z General Partner Vijay Pande, as he says, this next wave of biological computing will “be the mother of many new exponentials to come.” Resources: Save As: DNA Part 1: https://exo.substack.com/p/saving-our-story-in-dna-part-1Save As: DNA Part 1: https://exo.substack.com/p/save-as-dna-part-2 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As we close off 2023, we wanted to revisit some of our favorite episodes from the last year. From AI hardware, to healthcare regulation, to disrupting the world’s largest asset class, to the electrification of nearly everything… there’s  something in here for all listeners. Resources: AI Hardware, Explained:https://a16z.simplecast.com/episodes/ai-hardware-explainedChasing Silicon: The Race for GPUs: https://a16z.simplecast.com/episodes/chasing-silicon-the-race-for-gpusThe True Cost of Compute: https://a16z.simplecast.com/episodes/the-cost-of-computeAI Revolution: Disruption, Alignment, and Opportunity: https://a16z.simplecast.com/episodes/ai-revolution-disruption-alignment-and-opportunityThe Robot Lawyer Resistance; https://a16z.simplecast.com/episodes/the-robot-lawyer-resistanceThe Quest for AGI: Q*, Self-Play, and Synthetic Data: https://a16z.simplecast.com/episodes/the-quest-for-agi-q-self-play-and-synthetic-dataThe Road to Autonomous Vehicles: Are We There Yet?: https://a16z.simplecast.com/episodes/the-road-to-autonomous-vehicles-are-we-there-yet-PstZz2G_The Electrification of Everything: From Sky to Sea: https://a16z.simplecast.com/episodes/the-electrification-of-everything-from-sky-to-seaWhen Two Giants Intersect: Healthcare Meets Fintech: https://a16z.simplecast.com/episodes/when-two-giants-intersect-healthcare-meets-fintechSalary Transparency: Clarity or Chaos?: https://a16z.simplecast.com/episodes/salary-transparency-clarity-or-chaosDisrupting the World’s Largest Asset Class with Adam Neumann: https://a16z.simplecast.com/episodes/disrupting-the-worlds-largest-asset-classThe Data Highway Above with Privateer’s Steve Wozniak, Alex Fielding, and Dr. Moriba Jah: https://a16z.simplecast.com/episodes/new-the-data-highway-above-with-privateers-steve-wozniak-alex-fielding-and-dr-moriba-jah Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Welcome to “The Ben & Marc Show”, featuring a16z’s co-founders Ben Horowitz and Marc Andreessen.  In this week’s episode, Marc and Ben are joined by special guest Tony Robbins to discuss the future of longevity.  Tony Robbins is an entrepreneur, #1 NY Times bestselling author, philanthropist, and the nation’s #1 life & business strategist.  For over four and a half decades, Tony has empowered more than 50 million people from 100 countries around the world through his audio programs, educational videos, and live seminars. He’s also the author of six international bestsellers, including “Money: Master the Game” (2014), “Unshakable: Your Financial Freedom Playbook” (2017) and “Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life and Those You Love” (2022).Joined by a16z’s own Dr. Vijay Pande, PhD – General Partner since 2014, and founder and leader of a16z Bio + Health – the group discusses new breakthroughs in regenerative medicine, AI, biohacking, gene editing, mindset and confirms why this might be the best time to be alive. Enjoy!Watch the full video version of this episode: https://youtu.be/V8h11baC_ok Resources:Marc on X: https://twitter.com/pmarcaMarc’s Substack: https://pmarca.substack.com/Ben on X: https://twitter.com/bhorowitzDr. Vijay Pande on X: https://twitter.com/vijaypandeLearn more about Tony Robbins: https://tonyrobbins.comTony’s Time to Rise Summit (Jan 25-27, 2024): https://timetorisesummit.com/join-now  Pre-order Tony’s upcoming book “The Holy Grail of Investing” (Feb 2024): http://theholygrailofinvesting.com Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

A new age of maritime exploration, the rise of the developer as a buyer in financial services, and more applications for computer vision and video intelligence. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in 2024.Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?Topics Covered:00:00 - Big Ideas in Tech 202401:39 -  Big Idea: The Rise of the Developer as a Buyer in Financial Services07:03 - Examples of financial service infrastructure products08:40 - Building products and cost/selling structures09:56 - How financial institutions will adopt new technology13:07 - Regulatory shifts and updates14:09 - The impact on customers16:30 - Big Idea: A New Age of Maritime 18:15 - The challenges of maritime exploration 19:56 - Why is 2024 the year of iInnovation in maritime exploration?23:32 - Space and aerospace exploration’s impact on maritime 26:51 - Geopolitical supply chain and climate applications29:40 - Autonomous fleets31:49 - Key challenges in modernizing maritime 34:11 - Opportunities for builders in the space36:23 - Big Idea: New Applications for Computer Vision and Video Intelligence38:06 - The current use of video and it’s data38:53 - The unlocks in hardware and software driving change41:40 - Emerging applications and use cases43:20 - Video and privacy44:49 - Why is 2024 the year of change and innovation?Resources:Find Angela on Twitter :https://twitter.com/astrangeFind Grant on Twitter: https://twitter.com/grant__gregoryFind Kimberly on Twitter: https://twitter.com/kimberlywtanView all 40+ big ideas: https://a16z.com/bigideas2024Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

General Partner Anjney Midha explores the cutting-edge world of text-to-video AI with AI researchers Andreas Blattmann and Robin Rombach. Released in November, Stable Video Diffusion is their latest open-source generative video model, overcoming challenges in size and dynamic representation.In this episode Robin and Andreas share why translating text to video is complex, the key role of datasets, current applications, and the future of video editing.Topics Covered: 00:00 - Text to Video: The Next Leap in AI Generation02:41 - The Stable Diffusion backstory04:25 - Diffusion vs autoregressive models06:09 - The benefits of single step sampling09:15 - Why generative video?11:19 - Understanding physics through AI video12:20 - The challenge of creating generative video15:36 - Data set selection and training17:50 - Structural consistency and 3D objects19:50 - Incorporating LoRAs21:24 - How should creators think about these tools?23:46 - Open challenges in video generation 25:42 - Infrastructure challenges and future research Resources: Find Robin on Twitter: https://twitter.com/robrombachFind Andreas on Twitter: https://twitter.com/andi_blattFind Anjney on Twitter: https://twitter.com/anjneymidhaStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Voice-First Apps, AI Moats, Never-Ending Games, and Anime. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in 2024.Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?Timecodes:00:00 - Big Ideas in Tech 202401:39 - Big Idea: Voice-First Apps Will Become Integral to Our Lives04:14 - The limiting factors of voice technology05:27 - What would a voice-first app look like? 06:52 - Voice tech for companionship and productivity 08:05 - The primary modality voice applications10:08 - How builders and founders can integrate voice technology13:31 - Big Idea: The Consumer AI Battleground Moves from Model to UX15:49 - How user experience can contribute toward building a moat17:57 - The commoditization of models19:55 - How should builders differentiate between model and experience?22:58 - Breakout examples for 202425:10 - Open source vs closed source26:44 - The impact of applications splitting from the infrastructure layer28:14 - Big Idea: AI-First Games That Never End29:59 -Generative AI in gaming and AI native games31:12 - Introducing generative agents as game companions 33:57 - Does the gaming community want hyper personalization?38:00 - New entrants vs the incumbents41:57 - How business models and cost structures are evolving46:21 - Advice for game builders in 202448:03 - Big Idea: Anime Games Go Mainstream49:28 - What defines anime?52:05 - Anime’s monetization strategy and how it differs from other genres54:04 - Why are we seeing a rise in anime?55:56 - What is required to be successful in anime58:20 - AI, XR and inventing the next wave of anime Resources:View all 40+ big ideas: https://a16z.com/bigideas2024 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Arthur Mensch is the co-founder of Mistral and the co-author of Deepmind’s pivotal 2022 "Chinchilla" paper.In September 2023, Mistral released Mistral-7B, an advanced open-source language model that has rapidly become the top choice for developers. Just this week, they introduced a new mixture of experts model – Mixtral — that’s already generating significant buzz among AI developers.As the battleground around large language models heats up, join us for a conversation with Arthur as he sits down with a16z General Partner Anjney Midha. Together, they delve into the misconceptions and opportunities around open source; the current performance reality of open and closed models; and the compute, data, and algorithmic innovations required to efficiently scale LLMs.Resources:Find Arthur on Twitter: https://twitter.com/arthurmenschFind Anjney on Twitter: https://twitter.com/anjneymidhaLearn more about Mistral: https://mistral.aiLearn why we invested in Mistral: https://a16z.com/announcement/investing-in-mistral/Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Smart energy grids. Voice-first companion apps. Programmable medicines. AI tools for kids.
We asked over 40 partners across a16z to preview one big ideathey believe will drive innovation in 2024.Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?View all 40+ big ideas: https://a16z.com/bigideas2024 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

One topic at the center of the AI universe this week is a potential breakthrough called Q*. Little has been revealed about this OpenAI project, other than its likely relationship to solving certain grade-school mathematical problems.Amid much speculation, we decided to bring in our new general partner, Anjney Midha – focused on all things AI – to sift through the sea of noise.Today, we discuss the key frontier research areas that AI labs are exploring on their path toward generalizable intelligence, from self-play, to model-free reinforcement learning to synthetic data. Anjney also shares his insights on which approach he expects to be most influential in the next wave of LLMs and why math problems are even a suitable testing ground for this kind of research. Topics Covered:02:03 - What is Q*?06:21 - Applying model-free reinforcement learning to complex spaces13:17 - The role of self-play19:04 - Synthetic data’s big unlock24:44 - What does this unlock for society? Resources:Follow Anjney on Twitter: https://twitter.com/AnjneyMidha Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @davidmarcus @smc90This wide-ranging conversation covers company building, big to small -- including what cadence and when is the right "time" to ship; the relationship between centralization, decentralization, platforms, and financial freedom; moving from web2 to web3 in both crypto AND payments... as well as why bitcoin, views on remote work, and much much more. Our guest is David Marcus, CEO and co-founder of Lightspark; Marcus was also a co-creator of Diem (aka Libra and Novi, the cryptocurrency project initiated by Facebook). Before that, he was vice president of messaging products there, where he ran the Facebook Messenger unit; and prior to joining Facebook, Marcus was the former president of PayPal (which had acquired his previous startup).  This episode begins with an interview just to help kick things off and then features a rich set of questions from the audience -- as this originally took place live on stage at our Crypto Startup School 2023. As a reminder: none of this should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.related readings:Regulate apps, not protocols series (2022-2023) - Miles Jennings et al, a16z crypto)What it will take to create the next great Silicon Valleys (2014) - Marc Andreessen (Politico, a16z)Why bitcoin matters (2014) - Marc Andreeessen (NYT, a16z)When one app rules them all: The case of WeChat and Mobile in China (2015) - Connie Chan (a16z) Subscribe to web3 with a16z: https://link.chtbl.com/web3witha16z Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Taking a company from idea to household name is always difficult. But the past few years presented challenges that caught even the most-seasoned CEOs off guard.In this episode, you’ll hear from two CEOs that navigated these waters and somehow, came out on the other side. These recordings come straight from our exclusive Connect/Enterprise event, bringing together top executives across the a16z network. Resources:Additional content from Connect/Enteprise:Enterprise Startups: Advice on Hiring, Firing, Scaling, and SellingBuilding Products With Generative AI Learn more about company-building: https://a16z.com/category/company-building/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Fei-Fei Li, PhD,  Professor in the Computer Science Department at Stanford University, and Co-Director of Stanford’s Human-Centered AI Institute, joins Bio + Health founding partner Vijay Pande.In this candid conversation, Li unfolds her transformation from a young immigrant to an influential figure in AI. The conversation explores the birth of ImageNet, a pivotal step that bridged the gap between visual intelligence and accessible AI technology. They delve into the notion of a 'Dignity Economy,' hinting at a future where technology serves to elevate human experience rather than undermine it. Li also touches on the delicate balance between relentless innovation and life's humble pursuits. This episode peels back the layers on the human side of AI, offering a rare glimpse into the personal and professional realms of a pioneer shaping the AI landscape.Check out her new book, The Worlds I See, here: https://us.macmillan.com/books/9781250897930/theworldsiseeCheck out other episodes form our sister podcast, Bio Eats World: https://a16z.com/podcasts/bio-eats-world/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Is it possible to construct a virtual society that authentically replicates human behavior? AI Town, a virtual town experiment where AI residents live, interact, and engage, provides valuable insights into the future of AI's believability and its interaction with humanity.In this panel discussion, Joon Park, the author of 'Generative Agents: Interactive Simulacra of Human Behavior,' and Martin Casado from a16z, discuss  the influence and potential of Generative Agents, exploring their practical applications in the real world.Topics Covered00:00 - Simulating human behaviors04:49 - What are generative agents?07:47 - Simulations, new technology, and LLMs11:45 - The architecture behind simulating human behavior16:37 - Generative agents interactions: observing, planning, and reflecting20:22 - What is the value in advancing generative agents?24:01 - Use cases for simulation behavior technology29:31 - What are the ethical frameworks?33:12 - Q&A from the audience Resources: Find AI Town: https://www.convex.dev/ai-townRead the paper ‘Generative Agents: Interactive Simulacra of Human Behavior’: https://arxiv.org/pdf/2304.03442.pdfFind Joon on Twitter: https://twitter.com/joon_s_pkFind Martin on Twitter: https://twitter.com/martin_casadoFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Software crosses borders effortlessly. The globalization of money, however, is considerably more challenging. This is especially true for multinational businesses, which grapple with managing multiple accounts in diverse currencies, navigating costly foreign exchange rates, and unpredictable money transfers.As businesses increasingly embrace a global default, top fintech entrepreneurs are rising to the challenge, addressing cross-border infrastructure issues and offering comprehensive solutions.In this episode, a16z partners Angela Strange, Joe Schmidt, and Gabriel Vasquez discuss the challenges of cross-border payment infrastructures and what fintech entrepreneurs are doing to create a more integrated, financially inclusive world.Topics Covered:00:00 - Software crosses borders easily; money does not. 03:02 - Why has global payments been a challenge for so long? 05:44 - How global payments and money currently moves07:25 - The metrics used to measure a country's financial health12:13 - The impact of regulation on financial services16:23 - Can the same regulations be applied to any country? 21:29 - Why each country has its own fintech system24:54 - Opportunities in global payments infrastructure34:47 - Advice for founders navigating global fintech systems36:58 - What does a truly global system enable? Read the Fintech Fuels Global Payments package: https://a16z.com/global-paymentsWatch ​​’Foreign Exchange 101: What Happens When You Send Money Abroad?’: https://youtu.be/eoXdyO9oGJc?feature=sharedFind Angela on Twitter: https://twitter.com/astrangeFind Joe Schmidt on Twitter: https://twitter.com/joeschmidtivFInd Gabriel Vasquez on Twitter: https://twitter.com/GEVS94Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Subscribe to The Ben & Marc Show on Apple Podcasts: https://bit.ly/3SdsfNtSubscribe to The Ben & Marc Show on Spotify: https://spoti.fi/3SclPOrRead the full manifesto: https://a16z.com/the-techno-optimist-manifesto/ This past week, Marc released his new vision for the future – “The Techno-Optimist Manifesto”.In an article that has sparked widespread conversation across traditional and social media, Marc challenges the pessimistic narrative surrounding technology today, and instead celebrates it as a liberating force that can lead to growth, progress and abundance for all. In this one-on-one conversation based on YOUR questions from X (formerly Twitter), Ben and Marc discuss how technological advancements can improve the quality of human life, uplift marginalized communities, and even encourage us to answer the bigger questions of the universe.We hope you’ll be inspired to join us in this Techno-Optimist movement. Enjoy! Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As VR technology inches forward, completely new experiences loom on the horizon.In today’s episode, we expose listeners to the very real-world use cases already present on these devices, from fitness to education.First up is Gym Class VR, one of the top-rated apps on the Quest. Cofounder, Paul Katsen, shows us how to dribble and dunk in the metaverse, but more importantly, discusses the social impact of VR, the technological prerequisites to get there, and the role of AI as we progress.Following on is a founder on a mission to revolutionize education. Anurupa Ganguly from Prisms VR, explores how virtual reality has the potential to close the gap – one where 70% of US 8th graders are not proficient in foundational math.Head over to our YouTube channel to see two a16z Podcast firsts: a full interview in VR, and host Steph slam dunking on an NBA court. Topics Covered: 00:00 - The current state of VR03:38 - How do you build the #1 VR app?05:56 - How will VR become an everyday activity?07:37 - The social and the technical arc of VR11:47 - Untapped opportunities in VR13:24 - Integrating AI into VR17:09 - Prisms VR20:10 - Why it’s critical to fix America’s math problem21:12 - Why put VR in classrooms now?23:23 - The successes of VR in the classroom26:03 - Stats from the impact report27:44 - Other curriculums could benefit from VR 31:04 - Opportunities for AI in VRResources:Find Paul on Twitter: https://twitter.com/pavtalkLearn more about Gym Class: https://www.gymclassvr.comFind Gym Class in Meta Quest: https://www.meta.com/experiences/3661420607275144/Find Anurupa on LinkedIn: https://www.linkedin.com/in/anurupa-ganguly-92790379Learn more about Prisms VR: https://www.prismsvr.comStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode continues our coverage from a16z’s recent AI Revolution event. You’ll hear directly from a16z cofounder Ben Horowitz and Databricks cofounder and CEO, Ali Ghodsi as they answer questions around AI and the enterprise, plus their perspectives on open source, whether benchmarks are BS, and the scramble of universities to take part in the very wave they kicked off decades ago.If you’d like to access all the talks from AI Revolution in full, visit a16z.com/airevolution. Resources:Find Ali on Twitter: https://twitter.com/alighodsiFind Ben on Twitter: https://twitter.com/bhorowitzCheck out Databricks: https://twitter.com/databricks Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode continues our coverage from a16z’s recent AI Revolution event. You’ll hear a16z Bio & Health GP Vijay Pande speak with Daphne Koller about the fascinating convergence of machine learning and genomics – two industries that have benefitted decades of investment and progress – which are now colliding head on.Daphne is a prominent innovator at this intersection, as a long-time professor in computer science at Stanford and co-founder of Coursera, who has decided to step back into the arena with her company Insitro. In fact, Insitro is a blend of in silico and in virto!If you’d like to access all the talks from AI Revolution in full, visit a16z.com/airevolution. Resources:Find Daphne on Twitter: https://twitter.com/DaphneKollerFind Vijay on Twitter: https://twitter.com/vijaypandeFind Insitro on Twitter: https://twitter.com/insitro Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying attention to. You’ll hear discussion around the real-world impact of this revolution, on industries ranging from gaming to design, and the considerations around alignment along the way.This footage is from an exclusive event, AI Revolution, that a16z ran in San Francisco recently. If you’d like to access all the talks in full, visit a16z.com/airevolution. Topics Covered:00:00 - AI Revolution02:39 - Putting technology in users’ hands08:21 - AI alignment and safety21:44 - Future opportunities Resources: Catch the all the talks at https://a16z.com/airevolution Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying attention to. You’ll hear about the economics of AI, broad vs specialized models, the importance of UX, and whether we can expect scaling laws to continue.This footage is from an exclusive event, AI Revolution, that a16z ran in San Francisco recently. If you’d like to access all the talks in full, visit a16z.com/airevolution. Topics Covered00:00 - AI Revolution01:42 - The economics of AI06:55 - The third epoch of compute13:52 - Recognizing scaling laws17:42 - Can scaling laws continue?22:34 - Potential bottlenecks25:58 - Personalization vs generality29:43 - The importance of UX31:55 - The future of multi-modality Resources:Catch the all the talks at https://a16z.com/airevolution Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The space industry is evolving rapidly, with the cost of launching payloads to orbit dropping significantly. But who's investing in this sector, and how will it evolve? In this episode, we delve into the transformative journey of the satellite industry with Andy Lapsa, co-founder of Stoke Space. With over a decade of experience at Blue Origin, Andy is now at the forefront of sustainable space travel, pioneering fully reusable rockets.Don’t forget to check out Part 1 in this mini series, where we explore the public and private players in space with John Gedmark from Astranis. Resources: Learn more about Stoke: https://www.stokespace.comFind Andy on Twitter: https://x.com/AndyLapsa?s=20 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The cost of launching payloads to orbit has dramatically dropped, igniting a space renaissance. In 2022, a record 186 rocket launches (41 more than the previous year!) underscores this shift.In Part 1 of our satellite economy mini-series, we sit down with John Gedmark, co-founder of Astranis, to reflect on today's innovations, who’s on the other side of the satellite market, the capabilities they’re looking for, competition, and their mission to provide internet access to 4 billion underserved people.Look out for Part 2, where we tackle the challenges of rapidly reusable rockets with Andy Lapsa from Stoke Space. Resources: Learn more about Astranis: https://www.astranis.comFind John on Twitter: https://x.com/Gedmark?s=20 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @alive_eth @danboneh @smc90This week's all-new episode covers the convergence of two important, very top-of-mind trends: AI (artificial intelligence) & blockchains/ crypto. These domains together have major implications for how we all live our lives everyday; so this episode is for anyone just curious about, or already building in the space. The conversation covers topics ranging from deep fakes, bots, and the need for proof-of-humanity in a world of AI; to big data, large language models like ChatGPT, user control, governance, privacy and security, zero knowledge and zkML; to MEV, media, art, and much more. Our expert guests (in conversation with host Sonal Chokshi) include: Dan Boneh, Stanford Professor (and Senior Research Advisor at a16z crypto), a cryptographer who’s been working on blockchains for over a decade and who specializes in cryptography, computer security, and machine learning -- all of which intersect in this episode;Ali Yahya, general partner at a16z crypto, who also previously worked at Google -- where he not only worked on a distributed system for a fleet of robots (a sort of "collective reinforcement learning") but also worked on Google Brain, where he was one of the core contributors to the machine learning library TensorFlow built at Google.The first half of the hallway-style conversation between Ali & Dan (who go back together as student and professor at Stanford) is all about how AI could benefit from crypto, and the second half on how crypto could benefit from AI... the thread throughout is the tension between centralization vs. decentralization.  So we also discuss where the intersection of crypto and AI can bring about things that aren't possible by either one of them alone...pieces referenced in this episode/ related reading:The Next Cyber Reasoning System for Cyber Security (2023) by Mohamed Ferrag, Ammar Battah, Norbert Tihanyi, Merouane Debbah, Thierry Lestable, Lucas CordeiroA New Era in Software Security: Towards Self-Healing Software via Large Language Models and Formal Verification (2023) by  Yiannis Charalambous, Norbert Tihanyi, Ridhi Jain, Youcheng Sun, Mohamed Ferrag, Lucas CordeiroFixing Hardware Security Bugs with Large Language Models (2023) by Baleegh Ahmad, Shailja Thakur, Benjamin Tan, Ramesh Karri, Hammond PearceDo Users Write More Insecure Code with AI Assistants? (2022) by Neil Perry, Megha Srivastava, Deepak Kumar, Dan BonehAsleep at the Keyboard? Assessing the Security of GitHub Copilot's Code Contributions (2021) by Hammond Pearce, Baleegh Ahmad, Benjamin Tan, Brendan Dolan-Gavitt, Ramesh KarriVoting, Security, and Governance in Blockchains (2019) with Ali Yahya and Phil Daian    As a reminder: none of the following should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including to a link to a list of our investments – especially since we are investors in companies mentioned in this episode. Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

With recent landmark legislation being passed around salary transparency, many companies are playing catch up as they interpret and implement changes.In this episode, members of the a16z People Operations team,  Shannon Schiltz and Brandon Cherry explore how companies can best prepare themselves to not just survive, but thrive in this new environment. Topics Covered:00:00 - Salary transparency legislation01:52 - The culture around pay transparency 03:39 - What is the legislation?07:01 - How are companies reacting?11:03 - Structuring a compensation philosophy 12:30 - Pay ranges15:35 - Exceptions to the pay range18:17 - Leveling staff22:30 - Ranges and roles and company growth28:24 - Location based pay30:05 - What should employees look for when applying for work?32:19 - Job postings35:05 - Reviewing compensation ranges 35:42 - At what stage do you hire help? Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

How many people spend more time organizing their “second brains”, instead of leveraging the information within them? With consumer AI now capable of processing simple language prompts and interfacing with unstructured data, is the landscape of information management on the brink of a transformative evolution?Founders of Mem, Kevin Moody and Dennis Xu, plus writer Nat Eliason, explore what’s gotten in the way of a true second brain, and how AI may finally unlock what “knowledge management” tools have promised for so long.  Topics Covered:00:00 - A true second brain02:45 -  Knowledge management06:01 - Thiago Forte's ‘Building a Second Brain’10:24 - Digital hoarding12:53 - The fun of organizing 14:16 - Levels of utility19:09 - Can the unstructured nature of AI help?21:46 - What does a second brain unlock? 25:23 - Time spent  searching for information31:07: LLMs and technology unlocks34:22 - Personalization 36:24 - Is the second brain a new PA and EA?38:57 - Challenges44:32 - Moats and differentiators  Resources:Link to Mem’s website: https://mem.aiFind Kevin on Twitter: https://twitter.com/kevinfmoodyFind Dennis on Twitter: https://twitter.com/DennisHXuFInd Nat on Twitter: https://twitter.com/nateliasonNat’s course on Effortless Output in Roam: https://www.effortlessoutput.com/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this exclusive conversation from a16z’s Bio and Health BUILD Summit, founding partner Ben Horowitz sits down with general partner Jorge Conde. They discuss everything from the inspiration behind Ben’s book The Hard Thing About Hard Things, how the open Internet was secured, the difference between wartime and peacetime CEOs, scaling culture, and understanding how bio & healthcare differs from other forms of technology. Topics Covered:00:00 - Introduction02:09 - What are the most important lessons for a CEO?08:45 - Surprising leaders in history11:41 - Wartime CEO vs the peacetime CEO14:54 - Cultures role20:59 - Communication and scaling 25:39 - Culture as a moat27:46 - The interplay between startups and incumbents30:22 - Advice for founders on navigating AI Resources:Find Ben on Twitter: https://twitter.com/bhorowitzFind Jorge on Twitter: https://twitter.com/jorgecondebioBen’s Book: https://www.amazon.com/Hard-Thing-About-Things-Building/dp/0062273205 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

From artificial limbs to memory foam, many inventions have emerged from our quest to understand the cosmos. In this episode we explore cosmic history, space's impact on technology, and the enduring human fascination with space exploration. To take us on this journey is astrophysicist John Mather, a Nobel Prize winner for his work on the COBE satellite and a key figure in the James Webb Space Telescope project.Prepare to be intrigued and left with a sense of wonder about the universe's influence on our world. Topics Covered:00:00 –  Innovations through the pursuit of space03:52– John’s early life 06:44 – Proving The Big Bang Theory 13:30 – The mysteries of quantum mechanics15:10 –  Leading the James Webb Telescope17:12 – Images from James Webb20:32 – Are we alone? 24:20 – New telescopes25:18 – Engineering in space for earth29:31 –  What would you like to see solved in your lifetime?32:24 – What came before The Big Bang? 25:04 – Misconceptions about space37:17 – Can humans be a multiplanetary species?38:20 - Private vs public spending in space40:24 – What’s the future of space exploration? Resources:COBE satellite imagery: https://www.nasa.gov/topics/universe/features/cobe_20th.htmlImages from the James Webb Telescope: https://webbtelescope.org/imagesExoplanet transmission spectrum: https://webbtelescope.org/contents/media/images/2022/032/01G72VSFW756JW5SXWV1HYMQK4 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain

With students learning in more places and different ways than we have ever seen, the pace of change in education is dizzying. Can this progress narrow learning gaps exacerbated by COVID-19 or will it fuel divides? How can we make the most of this once-in-a-generation opportunity?Join our panelists from Khan Academy, PrismsVR, and Minecraft Education as we discuss the classroom of the future, and how important technologies including AI, XR, and gaming should play a role in it. Topics Covered:00:00 – The classroom of 202304:30 – Data on the current classroom05:40– Developing the next gen of STEM talent08:00 –  AI in the classroom 13:10 – The role of gaming in the classroom16:00 – Misconceptions of technology in classroom17:51 – The ways teachers and students use AI21:15 - The future role of a teacher24:25 – Personalization and ownership in education27:11 – Getting hardware into the classroom29:54 - Misconceptions of teacher’s abilities and appetite for tech31:25 – Why implement these changes now?36:05 – Call to action for the classroom of 2050 Resources:Find Sal Khan on Twitter: https://twitter.com/salkhanacademyFind Romy Drucker on Twitter: https://twitter.com/romydruckerFind Allison Matthews on LinkedIn: https://www.linkedin.com/in/allison-matthews-4050677/Find Anurupa on LinkedIn: https://www.linkedin.com/in/anurupa-ganguly-92790379/Learn more about Khan Academy: https://www.khanacademy.org/Learn more about The Walton Family Foundation: https://www.waltonfamilyfoundation.org/Learn more about Minecraft Education: https://education.minecraft.net/en-usLearn more about Prisms VR: https://www.prismsvr.com/Watch more panel discussions from The Aspen Ideas Festival 2023: https://www.aspenideas.org/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

With software becoming more important than ever, hardware is following suit.As the world generates more data, unlocking the full potential of AI means a constant need for faster and more resilient hardware. But how much does this all really cost? In this final segment of our AI hardware series, we tackle that question head on. Be sure to check part 1 and 2, where we explore the emerging architectures and the momentous competition for AI hardware. Topics Covered:00:00 – The cost of compute02:20 – Is this sustainable?03:23 – The cost to train a model05:39 – Computation requirements09:05  – The relationship between compute, capital, and technology11:15 – GPT4 commenting on the technology with help from ElevenLabs Resources: Find Guido on LinkedIn: https://www.linkedin.com/in/appenz/Find Guido on Twitter: https://twitter.com/appenz Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

With the world constantly generating more data, unlocking the full potential of AI means a constant need for faster and more resilient hardware.In this episode – the second in our three-part series – we explore the challenges for founders trying to build AI companies. We dive into the delta between supply and demand, whether to own or rent, where moats can be found, and even where open source comes into play.Look out for the rest of our series, where we dive into terminology and technology that is the backbone of the AI, how much the cost of compute truly costs! Topics Covered:00:00 – Supply and demand02:44 –  Competition for AI hardware04:32– Who gets access to the supply available06:16– How to select which hardware to use08:39– Cloud versus bringing infrastructure in house12:43– What role does open source play? 15:47– Cheaper and decentralized compute19:04– Rebuilding the stack20:29– Upcoming episodes on cost of compute Resources: Find Guido on LinkedIn: https://www.linkedin.com/in/appenz/Find Guido on Twitter: https://twitter.com/appenz Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 2011, Marc Andreessen said, “software is eating the world.” And in the last year, we’ve seen a new wave of generative AI, with some apps becoming some of the most swiftly adopted software products of all time.So if software is becoming more important than ever, hardware is following suit. In this episode – the first in our three-part series – we explore the terminology and technology that is now the backbone of the AI models taking the world by storm. We’ll explore what GPUs are, how they work, the key players like Nvidia competing for chip dominance, and also… whether Moore’s Law is dead?Look out for the rest of our series, where we dive even deeper; covering supply and demand mechanics, including why we can’t just “print” our way out of a shortage, how founders get access to inventory, whether they should own or rent, where open source plays a role, and of course… how much all of this truly costs! Topics Covered:00:00 – AI terminology and technology03:44 - Chips, semiconductors, servers, and compute04:48 - CPUs and GPUs06:07 - Future architecture and performance07:01 - The hardware ecosystem09:05 - Software optimizations12:23 - What do we expect for the future?14:35 - Upcoming episodes on market  and cost Resources: Find Guido on LinkedIn: https://www.linkedin.com/in/appenz/Find Guido on Twitter: https://twitter.com/appenz Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Despite the ease of product building, sustainable growth has become increasingly challenging as many traditional channels no longer deliver the same results.In these challenging times, we explore the remaining growth opportunities. How can we achieve a balance between efficiency, profitability, and growth? Which channels are still relevant and how can they be effectively mastered in 2023?Join us as we discuss these questions with three seasoned experts who have successfully navigated similar confusing times in the past: Gina Gotthilf, leading Latitud and renowned for her impressive tenure as the VP of Growth at Duolingo; Kieran Flanagan, a long-time SVP of Marketing at HubSpot; and Bryan Kim, Consumer Partner at a16z, who held various leadership roles during Snap's hypergrowth phase up to its IPO. Topics Covered:00:00 – What growth opportunities exist in 2023?03:00 – What still works in growth?05:02 – The fundamentals and framework of growth07:02 – Assessing growth potential and product lead growth09:33 – Distribution11:15 – Your moat and growth14:00 – Integrating AI for product lead growth16:23 –Trust as a moat17:23 – B2C growth - discovery and breaking through18:51 – Can you get ahead of the incumbents?22:03 – Examples of companies and products24:59 – How do you foster a growth culture?28:38 – Experimentation  34:20 – How companies using AI in distribution44:43 – Growth challenge: What would you do with $10K? Resources:Check out Latitud: https://go.latitud.com/Check out Zapier: https://zapier.com/Find Bryan on Twitter: https://twitter.com/kirbyman01Find Kieran on Twitter :https://twitter.com/searchbratFind Gina on Twitter: https://twitter.com/ginag Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode is with Mark Cuban, founder of multiple businesses, owner of the Dallas Mavericks, one of the sharks on Shark Tank, and cofounder of the Mark Cuban Cost Plus Drug Company. He is joined by Vijay Pande, founding partner of a16z Bio + Health. Together, they talk market forces in healthcare, the importance of trust to patients, and Mark’s ideas to tackle the Gordian knot that is American healthcare. Listen to our last two episodes on Healthcare x Fintech:When Two Giants Intersect: Healthcare Meets FintechHow Fintech is Reshaping Our $4T Healthcare Industry Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Remote work is a big, divisive topic right now. Some think it’s the future, while others think it was an experiment gone wrong.But it’s also not the only way to attract top talent. And the equation for doing so has only gotten more confusion as a myriad of trends intersect, from layoffs to emerging technologies like AI.So how can companies navigate this storm and truly attract the talent that matters? Listen in to find out.Topics Covered:00:00 – Introduction03:26 – What it takes to attract top talent in 202306:36 – What employees really care about14:13 – Positives and negatives of benefits17:32 – Generational differences27:44 – Will the return to office work?34:35 – Differentiating through benefits38:35 – Advice to attract top talent44:16 – Closing thoughtsResources:A-Team study referenced:https://www.a.team/mission/college-grads-surveyiCIMS study referenced: https://www.dropbox.com/s/2q3hepreozaurte/iCIMS-Class-of-2021-Report.pdfMost recent iCIMS study: https://www.icims.com/wp-content/uploads/2022/08/iCIMS-2023-Workforce-Report-FINAL.pdfFind AJ on Twitter: https://twitter.com/ItsAJThomasFind Rob on Twitter: https://twitter.com/RobFrohweinFind Hung on Twitter: https://twitter.com/HungLeeCheck out Keep Financial: https://keepfinancial.com/Check out Recruiting Brainfood: https://www.recruitingbrainfood.com/

Self-driving cars have been on the horizon for quite some time. But, they might actually be here.We got to ride around in one all over San Francisco with Waymo’s Chief Product Officer, Saswat Panigrahi.We discussed so much, including the five levels of autonomy, the infamous LIDAR vs video debate, regulation, UX, and the role of AI in fine-tuning these models. But most importantly, if autonomy is here… now what?!Topics Covered:00:00 - Introduction03:20 - A first look at Waymo05:21 - 5 levels of autonomy09:45 - Technology challenges14:32 - LiDAR vs video debate18:19 - How Waymo differentiates19:01 - Technological unlocks on the horizon20:39 - The role of AI in autonomous vehicles25:37 - How Waymo views safety32:05 - Collaborating with regulators37:26 - Learnings from the first 2m miles39:45 - Driving user retention43:47 - Waymo’s expansion strategy47:00 - Changing regulation47:41 - Societal unlocks enabled by autonomy52:21 - Will self-driving cars replace humans?52:58 - Closing thoughtsResources:Check out Waymo: https://waymo.com/Check out Waymo's Youtube channel: https://www.youtube.com/@WaymoFind Saswat on Twitter: https://twitter.com/saswat101Check out a16z's 8-part series on the autonomous vehicle ecosystem: https://a16z.com/2018/02/03/autonomy-ecosystem-frank-chen-summit/Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @skominers @smc90In this deep dive and tour through key business concepts, from theory to practice, we cover the topics of strategy, competitive advantage,  network effects, moats, and more -- covering both both basic foundations, as well as the tricky nuances in a new world of open source, including web3.  In the first half of this discussion, we cover foundational business concepts and questions -- such as the nature of competition, and how it *really* changes in web3; as well as how network effects really work -- and then, in the second half (in case you want to skip ahead), we cover mindsets and general guidance for builders…Our expert guest -- in conversation with editor in chief and host Sonal Chokshi -- is a16z crypto research partner Scott Duke Kominers, who is also a professor at Harvard Business School; a faculty affiliate in Harvard’s Department of Economics; and advises several companies on marketplace development, incentive design, and more; as well as advises, and is directly involved, in several NFT communities. Scott also teaches on these topics -- both at Harvard and also recently at our Crypto Startup School -- so be sure to subscribe to our playlist for those talks on the a16z crypto YouTube channel to get the latest updates as we release more videos from the 2023 cohort.  Listen to web3 with a16z: https://web3-with-a16z.simplecast.com/related links // see also:Can web3 bring back competition to digital platforms? by Christian Catalini and Scott Duke KominersWhy build in web3 by Jad Esber and Scott Duke KominersVampire attacks: A theory (and thread) on 'blood sucking' platform competition by John William Hatfield and Scott Duke KominersWhy NFT creators are going cc0 by Flashrekt and Scott Duke KominersDecentralized identity: Your reputation travels with you by Scott Duke Kominers and Jad EsberIncreasing returns and the new world of business (1996) by W. Brian ArthurNetwork effects, origin Stories, and the evolution of tech with W. Brian Arthur, Marc Andreeessen, and Sonal ChokshiThe five competitive forces that shape strategy (2008 reformulation of 1979 paper) by Michael PorterStrategies for two-sided markets (2006) by Tom Eisenmann, Geoffrey Parker, and Marshall Van Alstyne Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This week, a16z’s own cofounder Marc Andreessen published a nearly 7,000-word article that aimed to dispel fears over AI's risks to our humanity – both real and imagined. Instead, Marc elaborates on how AI can "make everything we care about better." In this timely one-on-one conversation with a16z General Partner Martin Casado, Marc discusses how this technology will maximize human potential, why the future of AI should be decided by the free market, and most importantly, why AI won’t destroy the world. In fact, it may save it. Read Marc’s full article “Why AI Will Save the World” here: https://a16z.com/2023/06/06/ai-will-save-the-world/ Resources:Marc on Twitter: https://twitter.com/pmarca Marc’s Substack: https://pmarca.substack.com/ gptplaysminecraft - Twitch: https://www.twitch.tv/gptplaysminecraftWhy AI Will Save the World: https://a16z.com/2023/06/06/ai-will-save-the-world/Youtube discussion: https://www.youtube.com/watch?v=0wIUK0nsyUg Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The holy grail of company building is finding product-market fit. But what most people don’t tell you is that once you’ve found it, product-market fit brings its own set of challenges, particularly when it comes to scaling rapidly and hiring the right executives at the right time.Drawing from their extensive experiences, a16z cofounder Ben Horowitz and Databricks cofounder and CEO Ali Ghodsi sit down to talk about the hardest things about executive hiring and firing, and what is at stake.They dive into the common reasons an exec fails, why sometimes micromanagement is a good idea, and the difference between someone who has written a playbook and someone who has only run one.If you’d like to dive even deeper, the Growth team at a16z has spent the last year compiling insights from dozens of leaders at late-stage startups to literally write the book on hiring executives to scale. You can find that book at: http://a16z.com/executive-hiring-playbookTopics Covered:00:00 - When is it time to let someone go?05:41 - When do you give someone a chance to grow into the role?07:05-  Let go or level?09:27 - How do you have the tough conversation? 16:39 - Exit packages18:40 - Setting a new leader up for success24:27 - The importance of the first quick win 26:24 - The impact a new leader has on culture32:52 - Common ways new leaders fail37:35 - Closing thoughtsResources:Read the Executive Hiring: The Key to Scaling in the Growth Stages: http://a16z.com/executive-hiring-playbookLearn more about Databricks: https://www.databricks.comFind Ben on Twitter: https://twitter.com/bhorowitzFind Ali on Twitter: https://twitter.com/alighodsiStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures

Demand for electric cars is booming. More than 10 million electric cars were sold worldwide in 2022, and consumer behavior is changing as more people embrace alternative and sustainable modes of mobility.While the electrification movement is a critical element of climate action, it also presents new challenges - from the sky to the sea.In this episode, industry experts Gregory Davis, CEO of Eviation Planes, Mitch Lee, co-founder and CEO of Arc Boats, and Duncan McIntyre, founder and CEO of Highland Electric Fleets, dive into how the electrification movement is shaping the future of transport and technology.Topics Covered:00:00 - Introduction03:29 - The sustainable aviation industry04:47 - Electric school, municipal and government vehicles07:57 - Electric boats10:49 - What can be transferred from the EV car market?14:06 - Battery challenges and architecture19:06 - Providing grid services 22:55 - Building a multimodal business33:19 - Gaps in the market46:16 - Do you make, buy, or borrow?57:26 - What does the future look like for each industry?Resources:Learn more about Arc Boats: https://arcboats.comLearn more about Highland Electric Fleets: https://highlandfleets.comLearn more about Eviation: https://www.eviation.com Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Today’s episode is with Magi Richani, founder and CEO of Nobell Foods. She is joined by a16z Bio + Health general partner Vijay Pande.Together, they talk about the details of engineering plants to create the future of food, why Nobell started with soybeans to produce their cheese, and her dream of finding a cheese pizza—with Nobell cheese—at any pizza shop across the country.

Many companies today are grappling with a few things: an economic downturn, potential layoffs and restructuring, and trying to keep up with the latest tech trends… all while still maintaining a growth trajectory.In this episode, you’ll learn which companies are uniquely designed to weather this storm and what attributes these exponential organizations have. We’re joined by the co-authors of Exponential Organzations, Peter Diamandids and Salim Ismail, both also well-known for their involvement in XPrize and Singularity University, among many other companies.Topics Covered:00:00 - Introduction03:11 -What is an ‘Exponential Organization’?04:46 - What has changed in business since 201407:06 - Building companies with minimal cost supply ***11:49 - Can  incumbents become exponential organizations?16:27 - Massive Transformative Purpose (MTPs)19:04 - How can you tell if you have a good MTP22:34 - Unilever’s MTP23:27 - Staff on demand29:35 - Building interfaces and dashboards30:36 - The importance of experimenting34:19 - The economic downturn and restructuring38:00 - Peer-to-peer collaborative technologies42:30 - Digitizing your business43:53 - Kodak example45:37 - Automation and the humans role52:06 - How have you seen companies integrate AI?56:56 - Emerging roles due to exponential trends59:56 - The framework and diagnostic survey01:00:02 - Creating APIs you can build on01:05:00 - Opportunities in the marketResources:Attend the Exponential Organization workshop on June 6: https://www.diamandis.com/exoLearn more about Peter: https://www.diamandis.com/aboutLearn more about Salim: https://salimismail.com/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode, you’ll hear directly from 6 founders trying to reinvent the healthcare system with the help of Fintech.They’re tackling everything from the lack of price transparency, the complexity of billing, getting clinics paid on time, mental health support for the masses, virtual first-care, and the millions of Americans about to lose access to Medicaid. Topics Covered:00:00 - The biggest problems in healthcare02:22 - The lack of price transparency07:13 - The complexity of medical billing14:32 - Getting health clinics paid on time20:00 - Mental health support for the masses24:58 - Millions about to lose Medicaid29:12 - Adopting virtual-first careResources:Learn more about the intersection of Healthcare and Fintech: https://a16z.com/healthcare-meets-fintech/Check out Turquoise: https://turquoise.health/Check out Cedar: https://www.cedar.com/Check out Juniper: https://www.juniperplatform.com/Check out Headway: https://headway.co/Check out Propel: https://www.joinpropel.com/Check out Firefly: https://www.firefly.health/Find Chris on Twitter: https://twitter.com/crsevern?lang=enFind Florian on Twitter: https://twitter.com/flottobrasil?lang=enFind Jade on Linkedin: https://www.linkedin.com/in/jadeyychan/Find Andrew on Twitter: https://twitter.com/andrewlangadams?lang=enFind Jimmy on Twitter: https://twitter.com/jimmychen?lang=enFind Fay on Twitter: https://twitter.com/fyietc Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

2022 was a breakout year for AI. While machine learning had already been integrated into applications for millions of users, for many, these tools still felt like their first real-world encounter with AI.As AI continues to revolutionize industries, CEOs are discussing how to integrate this new superpower. They are also considering important questions around data privacy, competition, cost, accuracy, and speed.In today's episode, we talk with Cresta, Hex, and Sourcegraph, three companies at the forefront of integrating AI into their existing products. From navigating data privacy concerns to optimizing accuracy and managing costs, these leaders are navigating the complexities of this new superpower.Topics Covered:00:00 - Introduction02:51 - How AI can enhance customer service08:26 - Using AI to shape data and analytics09:33 - Solving the challenges on contextual understanding12:01 - Giving AI the right information and context13:31 - Tools that help build language Models (LLMs)15:39 - Building open source tools18:40 - Constructing prompts22:26 - How do you differentiate?23:48 - Customization as a moat25:26 - Privacy challenges29:14 - Language models and search engines30:41 - Cost and pricing of models32:48 - What does the contact center look like in 2028?Resources:Find Barry McCardel on Twitter https://twitter.com/barraldFind Beyang Liu on Twitter: https://twitter.com/beyangFind Zayd Enam on Twitter: https://twitter.com/zaydenamRecent AI episodes:From Promise to Reality: Inside a16z's Data and AI ForumBeyond Avatars: How AI is Reshaping Online IdentityUnlocking Creativity with Prompt EngineeringStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see

Most people don’t need a reminder of the state of healthcare in America. But it’s not just the consumer that’s hurting.  Medical debt is increasing, billions are lost in unpaid claims, hospitals are in the red, service prices can range up to 30x…. In this episode, a16z GPs Julie You and David Haber explain where the healthcare system breaks down and how the three party system — between payors, providers, and consumers — can be rethought through the lens of Fintech.Learn more about Healthcare x Fintech here: https://a16z.com/healthcare-meets-fintech/Topics Covered:00:00 - Introduction02:50 - The intersection of healthcare and fintech 05:40 - The problems within US healthcare 09:00 - The stats behind US healthcare12:10 - Where do the problems stem from in healthcare?15:50 - New opportunities and regulatory changes17:50 - Pushback on regulations19:40 - Provider and patient models and transparency21.10 -  The ‘No Surprises Act’ and the ‘Cures Act’23:20 - Applying fintech infrastructure to healthcare26:00 - Example: how Juniper in embedding fintech in healthcare30:10 - Opportunities in the healthcare/fintech market33:05 - Payvidors unbundled 34:55 - The financial operating system for healthcare37:40 - How founders can approach the problems39:23 - The investor standpoint on company opportunities41:00 - Unsolved problems in the market45:25 - The bridge between start-ups and incumbents 47:20 - Healthcare incumbent stats  48:50 - The window of opportunity for healthcare and fintechResources:Read the article ‘Healthtech x Fintech’s Biggest Prize: The Financial Operating System for Healthcare: https://a16z.com/2023/02/07/healthtech-x-fintechs-biggest-prize/Read the article ‘ Payvidors, Unbundled: Opportunities in Healthcare Fintech’:https://a16z.com/2022/06/01/payvidors-unbundled-opportunities-in-healthcare-fintech/Find Julie on Twitter :https://twitter.com/julesyooFind David on Twitter: https://twitter.com/dhaberStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Nvidia’s CEO Jensen Huang declared in a recent keynote, “we are in the iPhone moment of AI.”This special episode will give you an inside look into a16z’s Data and AI Forum, hosted the day GPT-4 came out, featuring many of the most influential builders in the space – from the companies building foundational models like OpenAI to those building the underlying infrastructure like AWS. Resources:Check out CoactiveAI: https://coactive.ai/Check out CharacterAI: http://character.ai/Check out Hex: https://hex.tech/Follow Cody on Twitter: https://twitter.com/codyaustunFollow Myle on Twitter: https://twitter.com/myleottFollow Barry on Twitter: https://twitter.com/barrald Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In a recent episode, we delved into the first wave of technology that was used to create digital influencers like 'Lil Miquela back in 2016.Fast forward to today, we're presented with a whole new set of tools that enable almost anyone to build their own digital influencer. In this episode, Sinead Bovell and Danny Postma discuss the transformative impact of artificial intelligence on the world of modeling, online creation, and self-representation.From the rise of AI-generated photos to the democratization of creativity, they discuss the potential of AI in shaping the future of digital expression.Topics Covered:00:00 - Introduction03:08 - The key insight08:00 - The photo studio of the future09:44 - Programs and models behind deep fakes10:58 - How the technology is used today12:36 - How real is today’s content?15:29 - The cost of a virtual model17:13 - Industry benefits19:28 - Market appetite23:25 - Evolving tech25:15 - Unlocking a new wave of creativity28:38 - Future predictions30:23 - Keeping up with tech32:02 - Finding a moat34:09 - Stacked AI models35:25 - Running your own GPUs and models37:33 - Product ideasResources:Find Danny Postma on Twitter: https://twitter.com/dannypostmaaHeadshot Pro, ProfilePicture.Ai plus all of Danny’s projects at: https://www.postcrafts.com/Find Sinéad Bovell on Instagram: https://www.instagram.com/sineadbovell/?hl=en Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

There is arguably nothing that impacts our daily lives more than consumer technology. This technology can drive our ability to change careers, build an audience, or feel understood. And in this episode, listeners get a sneak peek into our new consumer series, Field Notes, where a16z’s very own Connie Chan speaks with the builders, creators, and investors behind the technology that shapes our daily lives.If you like these segments, you can find the full episodes at a16z.com/fieldnotes.Topics Covered:00:00 - Introduction02:13 - Chris Schroder08:15 - Brian Wong15:35 - Tracy Sun23:03 - Deb Liu30:56 - Susan PlagemannResources: Find the full series: https://a16z.com/fieldnotesFind Connie on Twitter: https://twitter.com/conniechanDeb's Part 1:  https://www.youtube.com/watch?v=Is2pm06MNt8Deb's Part 2: https://www.youtube.com/watch?v=osJp6S66u2UChris's episode: https://www.youtube.com/watch?v=Zux1wVirUjs Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

with @amandacassatt @kimbatronic @smc90All about marketing, and web3 -- not just for marketers already in or seeking to enter web3, but also anyone doing community marketing/ community management, devrel (developer relations); or simply doing marketing in web2 or classic growth marketing, seeking to understand the latest trends and tactics.With the  author of the new book, Web3 Marketing: A Handbook for the Next Internet Revolution, Amanda Cassatt (who was also the first CMO at ConsenSys, helping bring Ethereum to market; and also founded and leads the pioneering, native web3-marketing agency Serotonin). Also joining this episode to share insights on marketing web3 -- in conversation with host and editor in chief Sonal Chokshi -- is Kim Milosevich, CMO at a16z crypto, where she oversees brand, marketing, events, and communications (and before that was VP of communications at Coinbase, where she took the company through its direct listing while leading internal, policy, product, and corporate communications internationally). The episode also covers key top of mind questions for web3 builders and others, including how to do community marketing, manage "profiles" in decentralized and open source, and finding your audience... including feedback for product-market fit. And much. much more!

People often say that building a hardware company is like “playing on hard mode”. Building a hardware company during a global pandemic, with the unpredictability of supply chains and markets, is harder than hard. Trying to penetrate the phone market in particular – where only a few players own almost all the market share – is REALLY hard.In today’s episode we chat with Carl Pei, founder of Nothing. Between Nothing and previously co-founding OnePlus, Carl has twice managed to do what many others have failed to do. Nothing has sold over 1m units and built a team of over 400. In this episode, Carl chats with us about why he’s at it again, what it takes to successfully build hardware, and how he thinks about making technology fun again.Timestamps:02:11 - The hardware market02:53 - Breaking into the phone market05:19 - Securing factories and stakeholders07:39 - Differentiating products10:32 - Hardware design11:53 - Strengthening software proposition16:04 - Table stakes17:49 - Marketing and Youtube19:34 - Underestimating the value chain21:50 - Manufacturing23:27 - Supply chain26:05 - Remote work27:36 - The future of hardware30:45 - Breakthrough hardware32:35 - Making tech fun againResources:Nothing website: https://us.nothing.tech/Nothing’s Youtube channel: https://www.youtube.com/@NothingTechnologyFind Carl on Twitter: https://twitter.com/getpeidFind Nothing on Twitter: https://twitter.com/nothingNothing’s recently launched Ear (2): https://us.nothing.tech/products/ear-2Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

You’ve probably heard of ‘Lil Miquela. The 19 year-old Brazilian-American influencer has millions of followers and has partnered with the likes of Samsung and Prada. But despite capturing the hearts of many, she’s not real. But you probably haven’t heard her origin story. In this episode we take a trip back to 2016, to a world that looked much different to today, together with two of Miquela’s creators – Trevor McFedries and Isaac Bratzel – cofounder and Chief Design and Innovation Officer of Brud at the time.We learn what inspired the experiment and what early signs indicated that Miquela was not just a novel idea. In a world where spinning up an influencer, we learn what it took to capture mindshare, the pushback they’ve received, what a “scalable influencer” means, and what they think is to come. Resources:‘Lil Miquela on Instagram: https://www.instagram.com/lilmiquela/‘Lil Miquela on Youtube: https://www.youtube.com/channel/UCWeHb_SrtJbrT8VD-_QQpRAFind Trevor on Twitter: https://twitter.com/whatdotcd?lang=enFind Isaac on Twitter: https://twitter.com/izykbenjaminFind Brud on Instagram: https://www.instagram.com/brud.fyiIsaac’s new avatar company: https://www.avataros.com/ Timestamps:00:00 - Introduction02:18 - The key insight04:05 - A new breed of influencers06:25 - Miquela’s aesthetic09:30 - Early signs of success13:01 - Narrative and fan engagement16:45 - The technology18:14 - Expanding past Miquela22:34 - Traction and generative AI26:45 - A new reality31:55 - Early pushback33:38 - Misunderstanding reality36:23 - Fear of new technologies37:47 - New technological unlocks41:13 - Scalable influencersStay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Over the last decade, we’ve seen the marketplace model evolve and grow, and this year a16z is back with our fourth edition of the Marketplace100 – a ranking of the top private marketplaces by GMV – giving a unique window into what may be to come.This year’s list features nearly three dozen newcomers, including marketplaces for refurbished electronics, precious metals, and sustainably raised meat. And in this episode, we break down key trends from the report together with a16z’s Consumer partners Connie Chan, Olivia Moore, and Zach Cohen.If you’d like to see the full ranking of the largest consumer-facing marketplace startups and private companies, you can find the full report at https://a16z.com/marketplace-100.Resources:Find the full Marketplace 100 report: https://a16z.com/marketplace-100Find Connie on Twitter: https://twitter.com/conniechanFind Olivia on Twitter: https://twitter.com/omooretweetsFind Zach on Twitter: https://twitter.com/zachcohen25Topics Covered:00:00- Introduction02:28 - Why marketplaces? 05:18 - What metrics matter07:55 - Newcomers on the list09:49 - Entertainment and personalization13:46 - Curated marketplaces14:47 - Trust and safety21:23 - Mental health trends22:42 - Untapped supply24:40 - Disintermediation27:42 - Transient vs foundational trends31:33 - Companies entering the category36:52 - Sleeper categories for 2024 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

It’s both easier and harder than ever to build a successful podcast. In this episode, we chat with Sriram and Aarthi from the Good Time Show, who ventured into the world of audio peak pandemic and have since interviewed the likes of Elon Musk, Calvin Harris, and Naomi Osaka.We get their perspective on how to succeed in this competitive landscape, differentiation and the sliding scale of entertainment and information, the difference between an audience and a community, podcast analytics and how they’re changing, and even what Sriram has learned from his frontrow experience at Twitter recently.Topics Covered:00:00 - Intro02:20 - Podcast trivia06:07 - Starting a podcast08:45 - Differentiating13:10 - Information vs entertainment18:08 - Getting off the talk track20:40 - Growth and metrics22:31 - Authenticity27:10 - Secret sauce of podcasting28:10 - Advice for new podcasters29:58 - In-person events32:06 - Tech as a force for good34:50 - The next wave of social37:23 - Creator middle class41:16 - Podcast infrastructure42:55 - ChatGPT45:10 - Swapping lives with a celebrity52:26 - Your personal monopoly Resources:Find Sriram on Twitter: https://twitter.com/sriramkFind Aarthi on Twitter: https://twitter.com/aarthirFind Aarthi and Sriram on Youtube: https://www.youtube.com/@AarthiAndSriramCheck out the Good Time Show: https://www.aarthiandsriram.com/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

With every new technology, some jobs are lost while others are gained. People often focus on the former, but in this episode we chose to highlight the latter – a highly creative role that emerges alongside AI: the prompt engineer.Until AI can close the loop of its own, each tool still requires a set of prompts. Just like a composer feeds an instrument the notes to play, a prompt engineer feeds an AI a map of what to produce. And if we know anything from music it’s that composing great music takes great skill!In this episode we explore the emerging importance of prompting with Guy Parsons, the early learnings of how to do it effectively, and where this field might be going.Will the prompt engineer be more like the highly sought after DevOps engineer, or a proficiency like Excel that you find on every resume? Listen in to hear Guy’s take.Interested in the prompt competition? Email us at podpitches@a16z.com.Resources:DALL-E 2 Prompt Book: https://dallery.gallery/the-dalle-2-prompt-book/Find Guy on Twitter: https://twitter.com/GuyPGuy’s combining image experiment: https://twitter.com/GuyP/status/1612880405207580672Guy’s amorphous prompt experiment: https://twitter.com/GuyP/status/1608475973300948993Guy’s space duck: https://twitter.com/GuyP/status/1601342688225525761Prompt base: https://promptbase.com/Lexica: https://lexica.art/ Topics Covered: 0:00 - Introduction01:49 - DALL-E 2 Prompt Book05:29 - Parallel skills06:51 - 80/20 prompting10:16 - New ways of prompting13:44 - Pulling the AI slot machine18:09 - Comparing models21:04 - Requested features26:34 - Learning with AI27:58 - Practical use cases32:08 - A top 1% prompt engineer36:17 - The most popular images Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Starting in the 1960s, technology companies, funded by the U.S. Department of Defense, were essential for creating the processors that would eventually launch satellites and guide missiles. Half a century later, today’s tech companies can — and need — to move even faster and smarter, as international adversaries scale up their aggressions. In this episode, Anduril Industries Founder Palmer Luckey will discuss how Silicon Valley is using new technologies to build new tools, systems, and companies to defend our nation and its interests. Resources:American Dynamism Summit: https://a16z.com/AD-summit/Anduril’s website: https://www.anduril.com/Find Palmer on Twitter: https://twitter.com/PalmerLuckey Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

What happens when you don’t have the resources to fight for your rights? Whether it’s a major medical bill or a more minor parking ticket… even if you were in the right, is it easier to just… pay?Well, Joshua Browder's answer is Do Not Pay! He’s built a thriving company of the same name, that helps consumers “fight corporations, beat bureaucracy, and sue anyone at the press of a button.” Through the power of technology, DoNotPay has resolved over 2m cases successfully and in this interview we get to hear where Browder hopes to take the organization, including his first-hand account of his recent plan to bring the robot lawyer into the physical courtroom. Topics Covered:00:00 - Introduction01:51 - DoNotPay’s origin03:09 - Surprising laws05:49 - General counsel for consumers06:54 - The role of AI and technology09:26 - Ensuring quality counsel13:19 - Prioritizing features14:43 - Corporate pushback17:11 - Reshaping the legal system20:28 -  Entering the physical courtroom 24:50 - Cross border possibilities26:14 - Looping humans into modeling29:01 - Deflationary impacts30:05 - Recent pushback33:13 - Is AI already writing law?35:15 - Why is law so complex?37:54 - Entering the Supreme Court38:38 - Lawyer support39:47 - Looking forward43:07 - Building horizontal vs vertical45:28 - Does this law exist? Resources: DoNotPay: https://donotpay.com/Find Josh on Twitter: https://twitter.com/jbrowder1 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

What would you do if you believed in an idea but everyone said it would fail, nobody would fund you, and the industry was experiencing a nuclear winter?Despite experiencing exactly that, Sandbox VR founder Steve Zhao doubled down and invested all of his personal savings into the unproven business. 7 years and 1 bankruptcy later, Steve has built the world’s leading full-body VR experience with over 30 locations across the globe. In this interview, we get to chat with Steve about the many challenges he faced, how Sandbox made it through the pandemic, the future of VR, and the difficult task of tackling hardware, software, a new computing platform, and real estate. Resources:Check out Sandbox VR: https://sandboxvr.comFind Steve Zhao on Twitter: https://twitter.com/zhaosaurusLearn more about the Squid Game partnership: https://venturebeat.com/games/squid-game-is-coming-to-sandbox-vr-immersive-experience-locations/Watch Steph’s highlight video: https://sandboxvr.com/event/b0b22aad-7c73-475d-ab43-281a456ff590 Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

A small minority – likely less than 1% – of the world can code. Yet also widely known that the skillset tends to yield outsized returns, with developers generating some of the highest paying salaries out there.But the field is quickly shifting, especially with the advent of wide-scale AI. In this podcast, we get to chat with Amjad Masad, founder of Replit, about these foundational shifts.We cover how Replit has integrated AI into its platform and the implications on both current and future developers. It’s easier than ever to learn to code, but is it still worthwhile? Listen in to find out.Timestamps:00:00 - Introduction02:04 - What is Replit?04:15 - Stories behind Replit11:10 - The software hero’s journey13:09 - Making coding fun15:58 - AI powering software19:37 - Training your own models22:36 - Building UX around AI24:16 - The developer landscape26:23 - The 1000x engineer30:40 - Should you still learn to code?34:41 - What does AI enable?40:54 - Developing on mobile43:24 - A software labor market45:53 - Differentiating a marketplace48:23 - Building new market dynamics50:45 - Looking aheadResources: Replit: https://replit.com/Replit Ghostwriter: https://replit.com/site/ghostwriterReplit Bounties: https://replit.com/bountiesFind Amjad on Twitter: https://twitter.com/amasad Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

A few weeks ago, Apple released a stunning statistic: they’ve paid developers over $320B — yes, billion! — since the launch of the App Store in 2008, highlighting the cast opportunity in the marketplace.And around the same time, a16z Consumer Partner, Olivia Moore, compiled a list of the top apps across the US app store throughout 2022.In this episode, you’ll get to hear which apps made it to the top and what they have in common. Hint: the big winners were in social, but perhaps a new wave of social apps!We also get the scoop on what it really takes to not just hit #1, but stay there. This episode highlights numerous surprising examples ranging from a new-age Beanie Baby app, a viral talking dog, an app from 2012 that finally broke the top 10, and the Chinese app that’s been at #1 for a majority of 2023, and it’s not TIkTok!There are endless learnings about how new founders can take advantage of these opportunities.Timestamps:01:51 - Top apps in 202203:32 - A new era of social?07:22 - Hitting #109:30 - Staying on top11:20 - Building a sticky product13:46 - Growing an app in 202315:35 - User-generated growth17:48 - 2022 category winners20:39 - Anonymous social22:24 - Early monetization26:30 - Monetization trends31:07 - Leveraging platform shifts35:26 - Surprising hits37:50 - Looking toward 202339:38 - Invisible AI products41:46 - Limiting virality45:13 - Vertical social networks48:37 - When digital goes physical51:44 - TikTok growth53:27 - Geographic trends56:18 - A decade old app1:00:25 - App challengeResources: Follow Olivia on Twitter: https://twitter.com/omooretweetsOlivia's 2022 analysis: https://twitter.com/omooretweets/status/1605983056682045440Olivia's 2021 analysis: https://twitter.com/omooretweets/status/1483482099562602500Justine’s Boating app commentary: https://twitter.com/venturetwins/status/1616121691830390784Olivia’s Tinder subscription commentary: https://twitter.com/omooretweets/status/1616480480546942976Apps mentioned: BeReal: https://apps.apple.com/us/app/bereal-your-friends-for-real/id1459645446TikTok: https://apps.apple.com/us/app/tiktok/id835599320Gas App: https://apps.apple.com/us/app/gas/id1641791746Talking Ben the Dog: https://apps.apple.com/us/app/talking-ben-the-dog/id416345319Argo Boating Navigation: https://apps.apple.com/us/app/argo-boating-navigation/id1463869636NoteIt: https://apps.apple.com/us/app/noteit-widget-get-it-now/id1570369625Locket Widget: https://apps.apple.com/us/app/locket-widget/id1600525061LiveIn: https://apps.apple.com/us/app/livein-share-your-moment/id1606780589Slay: https://apps.apple.com/de/app/slay-komplimente-umfragen/id1645858841Lensa AI: https://apps.apple.com/us/app/lensa-photo-editing/id1436732536Starlink: https://apps.apple.com/us/app/starlink/id1537177988NOAA Weather: https://apps.apple.com/us/app/noaa-weather/id436760574Stardust Period Tracker: https://apps.apple.com/us/app/stardust-period-tracker/id1495829322Temu: https://apps.apple.com/us/app/temu-team-up-price-down/id1641486558SquadApp: https://apps.apple.com/us/app/squadapp-collection-database/id1623120952TravelBoast: https://apps.apple.com/us/app/travelboast-my-journey-routes/id1476504378Subway Surfers: https://apps.apple.com/us/app/subway-surfers/id512939461Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Back in August, after a16z announced our investment into Adam Neumann’s new company, Flow, it felt like almost everyone – whether it was other VCs, founders, or journalists – had something to say.But the one person that you didn’t hear from was Adam himself.In this never-before shared footage from a16z’s American Dynamism Summit in Washington DC, Adam Neumann sits down with Marc Andreessen and David Ulevitch, to discuss the opportunities that have emerged from post-pandemic shifts in both work and home, and what Flow is doing to capitalize.Find the full library of American Dynamism Summit recordings at a16z.com/ad-summit.Timestamps:00:00 - Introduction01:40 - Getting back in the arena 09:03 - The opportunity in housing 16:19 - Lessons from WeWork 19:13 - Work & home post-pandemic 27:34 - Moving to the cloud 34:23 - Office serendipity 37:51 - Building Flow 43:51 - Cities as startupsResources:Flow’s website: https://www.flow.life/American Dynamism recordings: https://a16z.com/ad-summit Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In this cross-over episode from Bio Eats World, Kristen Fortney, cofounder and CEO of BioAge, joins Vijay Pande, founding partner of a16z Bio + Health, and Olivia Webb, editorial lead, to discuss the biology of aging, how she started a company, and some fun things — like how long a hypothetical venture capitalist can expect to live. Resources:Greg Egan, whose writing inspired Kristen, has a list of his books on his website Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

At the end of 2022, our team at a16z asked dozens of partners across the firm to spotlight one big idea that startups in their fields could tackle in 2023.Emerging from this exercise came 40+ builder-worthy pursuits for the year, ranging from entertainment franchise games to precision delivery of medicine to small modular reactors, and of course loads of AI applications.In our 2-part series, we’ll be covering 12 of these big ideas with the partners that shared them.Here in part 2, we’ll cover Fintech, American Dynamism, and Bio & Health. Listen in as we chat with Anish Acharya, Angela Strange, Michelle Volz, Ryan McEntush, Vijay Pande, and Julie Yoo.And for the full list of 40+ ideas, check out the full article: https://a16z.com/2022/12/15/big-ideas-in-tech-2023/Topics Covered:(0:59) GPT Unlocks Credit Counseling - Anish Acharya(9:53) Compliance as a Competitive Advantage - Angela Strange(23:31) Small Modular Reactors Advance the Nuclear Renaissance - Michelle Volz(33:48) Overhauling the Space Supply Chain - Ryan McEntush(44:40) The Biggest Company in the World - Vijay Pande(51:17) The Value-Based Care Stack - Julie YooResources:https://a16z.com/2022/11/02/america-space-age/https://a16z.com/2022/11/11/the-biggest-company-in-the-world/https://a16z.com/2021/01/08/the-new-tech-stack-for-virtual-first-care/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

At the end of 2022, our team at a16z asked dozens of partners across the firm to spotlight one big idea that startups in their fields could tackle in 2023.Emerging from this exercise came 40+ builder-worthy pursuits for the year, ranging from entertainment franchise games to precision delivery of medicine to small modular reactors, and of course loads of AI applications.In our 2-part series, we’ll be covering 12 of these big ideas with the partners that shared them.Here in part 1, we’ll cover Consumer, Games, and Enterprise, with a little Fintech sprinkled in. Listen in as we chat with Connie Chan, Anne Lee Skates, Jack Soslow, Doug McCracken, Sarah Wang, and Sumeet Singh.And look out for part 2 dropping soon, covering Fintech, American Dynamism, and Bio & Health!For the full list of 40+ ideas, check out the full article: https://a16z.com/2022/12/15/big-ideas-in-tech-2023/Topics Covered:(1:30) Breakthroughs in Buying (Finally!) - Connie Chan(16:40) Unlocking the “Third Place” - Anne Lee Skates(30:14) Games as a Neverending Turing Test - Jack Soslow(46:09) The Metaverse Goes Fashion Forward - Doug McCracken(59:24) Generative AI Advances Beyond “Text to Image” to Complex Workflows - Sarah Wang(1:12:23) Embracing Large Language Models and Maintaining Trust - Sumeet SinghStay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In this special episode, we share never heard before footage from Steve Wozniak alongside his cofounder and best man, Alex Fielding. Listeners get an inside look into what drove Woz to building a computer, but also how Steve’s zest for life was applied beyond computers – from the rare opportunity to play Tetris on the side of a building or throw a concert across borders. Full Privateer episode: https://a16z.simplecast.com/episodes/new-the-data-highway-above-with-privateers-steve-wozniak-alex-fielding-and-dr-moriba-jahFull Privateer episode on Youtube: https://youtu.be/ZZbrwxOs0y4 Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

New year, new you! Right?Well, as much as we’d all like to believe that we embrace the new… the reality is that we often resist change.That’s why we’ve brought in someone who has studied how humans respond to and adapt to change – or sometimes how we fail to. That person is Jason Feifer – long-time editor in chief at Entrepreneur Magazine, host of two popular podcasts, and recent author of his book Build for Tomorrow. Today, Jason shares 6 specific frameworks around the very natural human responses to change, which he’s developed through interviewing and studying some of the most influential people in the world – past and present. We also play a fun game at the end, where Jason comments on current technologies encountering pushback, and assesses where they might fit into his framework. Jason’s website: https://www.jasonfeifer.com/Jason on Twitter: https://twitter.com/heyfeiferJason’s book Build for Tomorrow: https://www.jasonfeifer.com/book/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In this episode, Marc Andreessen and Vijay Pande discuss expert AI and its role in healthcare, bio, and more. Watch on Youtube: https://youtu.be/c7ScUDYSRYoSubscribe to Bio Eats World: https://podcasts.apple.com/us/podcast/bio-eats-world/id1529318900 Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

with @robertiger @cdixon @smc90A wide-ranging conversation with Bob Iger on the interplay between technology, content, and distribution; as well as Bob’s journey -- and that of various creators! -- especially as the industry evolved from TV and cable to the advent of the internet/ web 1.0 to 2.0 to briefly touching on web3 and other emerging technologies. As well as topics top of mind for all company and community builders: from build vs. buy and the innovator's dilemma, to managing creativity, decentralization, remote work, and much more. Subscribe to web3 with a16z: https://podcasts.apple.com/us/podcast/web3-with-a16z-crypto/id1622312549 Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

We’ve had some incredible guests join us on the a16z podcast this year, ranging from moonshot entrepreneurs, to top creators, to some of the most forward thinking technologists – all of which are busy shaping the future right before our eyes…We have so much more in store for 2023 and cannot wait for you to see who we bring on as guests. But before we turn the page, we wanted to recap some of the most interesting, thought-provoking segments from our 2022 roster. Here are 8 of our favorite clips, covering topics from AI to space to the metaverse… and beyond.Catch the full playlist here. Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

The predecessor to the office was Florence’s Uffizi Gallery – an admin building to the Medici mercantile empire. That was in… 1560. In the centuries to come, work was revolutionized, with perhaps the most well-known inflection of Ford Motors adopting the 40-hour work week in 1926. The cubicle? We have Robert Propst to thank for that, entering the picture in 1968. It wasn’t until the 80s when the Internet appeared on the scene and wifi released in 1997, forever changing the way people live and work. Since then, companies have continued to adopt many of the practices from the 20th century, despite the possibilities being fundamentally different.COVID sent a shock into that system, forcing many people to adopt a distributed model and despite much debate about what the future holds, this episode will highlight the many ways that companies are continuing to adapt.Will companies shift toward more asynchronous work? How will a distributed model shift the way we hire? How will companies attract top talent, and is remote the only benefit that matters? What workers and companies will come out on top of this sea change?And of course… is the office dead? We’ll address these questions, and much more!Topics covered:00:00 - History of remote work3:27 - Is the office dead?7:05 - Async vs sync16:18 - Building culture remotely27:15 - Attracting top talent31:16 - The evolution of benefits36:04 - Remote work vs work39:29 - Location-based pay46:36 - Open salaries51:23 - Vetting top talent55:32 - The need to adapt58:39 - Rewriting the rules1:03:09 - Infrastructure gapsResources: GitLab’s Remote Handbook: https://about.gitlab.com/handbook/Deel’s Salary Insights Tool: https://www.deel.com/salary-insightsDeel’s State of Global Hiring report: https://www.deel.com/state-of-global-hiring-2022Deel:Deel’s website: https://www.deel.com/Deel on Twitter: https://twitter.com/deelAlex on Twitter: https://twitter.com/BouazizalexSafetyWingSafetyWing’s website: https://safetywing.com/SafetyWing on Twitter: https://twitter.com/safetywingSondre on Twitter: https://twitter.com/SRaschGitLab: GitLab’s website: https://about.gitlab.com/GitLab on Twitter: https://twitter.com/gitlabDarren on Twitter: https://twitter.com/darrenmurph Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In this episode, we tackle three carbon removal projects of varying scale, business models, and technical challenges.Biomass pyrolysis via Charm IndustrialAn electrochemical process via TravertineMineralization via 44.01We cover these companies through the lens of their founders – Peter Reinhardt (CEO of Charm Industrial), Laura Lammers (CEO of Travertine), and Karan Khimji (COO of 44.01) – who share the fascinating stories of how they stumbled into this industry, how their processes work, whether they can economically scale, and ultimately why each of them is dedicating their time and energy to this field.This episode also closes out our carbon removal mini series, where we’ve seen a unique convergence of attention, capital, policy, and creativity being applied. With that combination, it's rare that humans don't surprise one another in progress. Resources: Charm Industrial:Charm Industrial’s website: https://charmindustrial.com/Charm Industrial on Twitter: https://twitter.com/CharmIndustrialPeter on Twitter:  https://twitter.com/reinpkTravertine:Travertine’s website: https://www.travertinetech.com/Laura on Twitter: https://twitter.com/limestonedr44.01:44.01’s website: https://4401.earth/44.01 on Twitter: https://twitter.com/4401earthKaran on Twitter: https://twitter.com/kdkhimji Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

If you’ve been following the news, you’ve probably heard of the recent FTX scandal.While there’s much still unknown, in this episode we get the unique opportunity to hear from Brian Armstrong – co-founder and CEO of Coinbase – about what’s top of mind for the crypto industry. That includes the impact of this current event on future regulation, how this crypto winter might be different from previous ones, founder psychology during downturns, the transparency that comes with being public, and much more.Brian is interviewed by a16z cofounder and general partner Ben Horowitz, who has the unique perspective of having invested in, built, and been on the board of numerous companies during the ups and downs, leading him to his well-known book The Hard Thing About Hard Things. Resources: Subscribe to web3 with a16z: web3-with-a16z.simplecast.com/Coinbase’s website: coinbase.comBrian’s Twitter: https://twitter.com/brian_armstrongBen’s Twitter: https://twitter.com/bhorowitz Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In part 1 of our carbon removal series, we talked to Nan Ransohoff — Head of Climate at Stripe — about what it might take to jumpstart the market of carbon removal solutions. But what happens when there is a true, thriving market of buyers and sellers? How will suppliers effectively reach the right buyers, and as more solutions become available, how will buyers effectively vet the options?In part 2, we address these questions and more, together with Brennan Spellacy, co-founder & CEO of Patch – a growing marketplace for carbon credits. We also cover many evolving market dynamics, like the potential differences between two sets of tons delivered, the opportunity and challenge of effectively educating buyers, the integration of software like Patch's API, verification solutions and their current limitations, how even the voluntary market is being held accountable for their carbon claims, and the role that Patch is playing to help develop this nascent industry.By the way, if you like this episode, be sure to look out for part 3 of our series where we get into the nitty gritty of 3 emerging carbon removal solutions — ranging from biomass pyrolysis to carbon mineralization. Resources: Patch’s website: https://www.patch.io/Follow Patch on Twitter: https://twitter.com/usepatchFollow Brennan on Twitter: https://twitter.com/bspellacy_ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

What happens when there’s demand for a solution that doesn’t quite exist yet?Today, we bring on Nan Ransohoff to talk about this exact problem as it relates to carbon removal, and how Frontier — the initiative out of Stripe that she is leading – is using a nearly $1B advanced market commitment fund to try to jumpstart this market.If you don’t know what that means, don’t worry – we’ve got you covered.Throughout the episode, we discuss the multivariate carbon equation and why emission reductions are not enough, the difference between offsets and permanent removal, who’s paying for tons today, what solutions already exist and how Frontier is vetting them, moving down the cost curve, where policy fits in, and ultimately what success might look like in this nascent industry.This is part 1 of our 3-part series on carbon removal. Look out next week for part 2 and part 3, where we dive into a growing marketplace for carbon and showcase several carbon removal solutions. Resources: Frontier’s website: https://frontierclimate.com/Nan’s Twitter: https://twitter.com/nanransohoffNan’s article: https://nanransohoff.com/A-mental-model-for-combating-climate-change-846be1769d374fa1b5b855407c93da66 Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In today’s episode, we have a special treat. Flexport’s co-CEO and Founder, Ryan Petersen, chats with a16z Growth Editor Das Rush. They start with the question of why Ryan has chosen – of all the problem spaces to work on – improving the resiliency of the supply chain. They cover just how complex the supply chain is in the era of ecommerce, evolving customer expectations, and ultimately how we can rearchitect our supply chain to meet them. Given the holiday shopping coming up, you won’t want to miss this.Timestamps:​​0:00 - Introduction1:24 - Why the supply chain?3:31 - Land and expand6:38 - The most interesting company?9:24 - The impact of ecommerce14:05 - Building resiliency Resources: Ryan’s Twitter: https://twitter.com/typesfastFlexport’s website: https://www.flexport.com/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

When Neal Stephenson coined “the metaverse” three decades ago, his book Snow Crash was found on the shelves of “science fiction”. While the book remains in that category, many of its concepts are now found in reality…Fast forward to 2022, where numerous companies are now building toward their version of the metaverse, including Neal himself – working on Lamina1 – a blockchain company oriented toward creators. While the present metaverses don’t perfectly mimic that from Stephenson’s early imagination, we get the unique opportunity to discuss the various design decisions that he’s making, but also the intersection between the metaverse and gaming, the involvement that AR/VR might play, the evolving role of IP, how artificial intelligence fits in, what he’s building and why, and where he gets all of his ideas from.Timestamps:0:00 - Introduction1:20 - Tech's highest impact position4:35 - What is the metaverse?6:46 - Interoperability8:52 - Incentive alignment13:06 - Immersion requirements16:30 - VR engineering challenges20:09 - Skeuomorphism24:17 - Commercial VR/AR applications27:26 - AI and gaming30:51 - The value chain38:13 - Right of refusal42:05 - Good and bad tech46:05 - Fighting “free”49:16 - Building Lamina158:07 - Neal’s design designs1:03:40 - Inspiration for Snow Crash1:09:16 - Looking ahead from 20221:11:59 - Science fiction writing1:13:46 - Carbon removal Resources: Neal’s Twitter: https://twitter.com/nealstephensonLamina1’s website: https://www.lamina1.com/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app:https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Today, we have an episode with Chris Power, the founder and CEO of Hadrian. Hadrian is a company trying to build the most efficient factories on the planet. In this conversation, we’ll introduce the audience to advanced manufacturing, and expose them to the reality that it’s a remnant of the first space race. We also cover the challenge of manufacturing, the importance of visibility in complex systems, the killer app for space, how simplifying the world of atoms can be done through bits – and ultimately, what kind of experimentation that may unlock.Timestamps: 0:00 - Introduction1:28 - What is advanced manufacturing?4:18 - When a hatch is jammed at the ISS6:11 - What’s happened since Space Race 1?8:56 - A retiring workforce13:20 - What is at stake?21:03 - Onshoring manufacturing24:06 - Is capital enough?24:43 - Fixing the problem with technology28:55 - Convincing the old guard31:20 - Building a new culture34:45 - Experimenting with hardware37:24 - The value of observability41:47 - The cost of timeliness46:09 - Hadrian’s key risks49:22 - Why Hadrian pivoted52:22 - What talent is needed57:31 - Why focus on space first?1:03:38 - The killer app of space1:10:36 - Who inspires Chris? Resources: Hadrian’s website: https://www.hadrian.co/Chris’ Twitter: https://twitter.com/2112Power Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In this episode, we’ll explore the concept of The Network State with Balaji Srinivasan. As the world becomes more digital, it also becomes more distributed. This is obvious on the individual level – how you order goods, the way you chat with friends, and the news you consume… all from a handheld computer. It’s also becoming more obvious at the company level. The pandemic shook the world into remote work and many companies have decided that maybe work can be done in ways they never imagined. But what about the state – whatever that means? Could the network rival the state? In this episode we’ll explore what a nation state even is and how it may be challenged by a new Leviathan: the network. We also cover the difference between a nation and a state, how constants become variables, the cloud continent, digital power, your identity stack, calibrating risk, polycentric law, cloud regulations, building fast with atoms, founding vs inheriting, the powerful vs the powerless, and just about everything in between.Timestamps: 0:00 - Introduction2:41 - Nation vs state14:38 - Constants becoming variables16:12 - The cloud continent20:10 - The three leviathans30:00 - Digital power37:20 - The identity stack53:22 - Cloud first, land last55:49 - Diplomatic recognition1:01:47 - Root access to land1:06:35 - Calibrating risk as society1:16:13 - Regulatory harmonization1:28:15 - Polycentric law1:34:49 - Building fast with atoms1:38:57 - Looking to history1:42:00 - Founding vs inheriting1:50:46 - The one commandment2:17:33 - The powerful vs powerless2:28:46 - The competition for people2:33:45 - Historical lines2:42:23 - v3 of governance Resources: Balaji’s Twitter: https://twitter.com/balajisBalaji’s website: https://balajis.com/The Network State: https://thenetworkstate.com/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.com/podcastsFollow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

With much coverage of technology lined with pessimism, the a16z Podcast returns to highlight the bright side of technology, alongside the founders building it. But before featuring the solutions in progress, we wanted to explore why building the future is still so important.And who better to traverse this ground than a16z’s own cofounder Marc Andreessen, who has built and invested in the future time and time again, especially when it wasn't the obvious thing to do.Together with Marc, this episode explores technology through the lens of history – including the three stages of human psychology as we encounter new technologies, how that process often manifests in regulation, when to change your mind, the Cambrian explosion of opportunity coming from distributed work, the importance of founder-led companies, and perhaps most importantly, we examine why there's still much reason for optimism.Timestamps: 00:00 - Welcome back!02:19 - The importance of tech today05:25 - Historical negativity toward technology9:40 - The invention of the bicycle13:16 - Innovation vs status in society20:45 - Automobile moral panic and red flag laws24:52 - Balaji’s arc on social networking27:44 - Surfacing signal from noise34:06 - The role of timing in innovation37:39 - Today’s major unlocks44:59 - Remote work and society reshuffling49:49 - Changing your mind54:06 - Retaining a lens of optimism1:04:25 - What Marc’s excited about1:08:41 - Bourgeois vs managerial capitalism1:17:32 - Reform vs starting anew Resources:Marc on Twitter: https://twitter.com/pmarcaPessimist’s Archive: https://pessimistsarchive.org/ Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.com/podcastsFollow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Many people consider space to be the next frontier and equally an infinite horizon to explore. But the reality is that not all “space” is the same and there are strategic zones that don’t only matter up there – but down here on Earth. Lower Earth Orbit (LEO) is one of those regions – a zone filled with satellites that support life on Earth, from agriculture to climate to navigation to defense. Unfortunately, these live satellites are not alone in our space highways. LEO is getting increasingly clogged with space debris; we’re polluting our skies just like we’re polluting our land. In this episode, we have the pleasure of speaking with all three cofounders of Privateer – Steve Wozniak, Alex Fielding, and Dr. Moriba Jah, as they explore just how much junk is up there, how this challenge is expected to progress with time due to lower launch costs, and ultimately, what infrastructure is missing in this fragile ecosystem – from tracking to global treaties to a sharing economy of satellites.By the end of the episode, listeners should be more equipped to understand how our infrastructure in space vastly impacts life on Earth, how the preservation of this ecosystem is crucial, and how Privateer is providing the map to better understand and fix the issue.Timestamps: With Steve Wozniak00:00 - Intro3:24 - Why space and why now?8:55 - The changing perception around space13:29 - Exponential technologies and thinking different16:32 - Inventors vs engineers vs visionaries18:46 - Early days at Apple and moving towards the future20:53 - Steve’s personal fascinations23:58 - How vocabulary drives awareness1:21:55 - Woz returns!With Alex Fielding and Dr. Moriba Jah24:43 - Is space really an infinite void?25:55 - The growing pollution in space29:14 - The impact of space down on Earth30:34 - The challenge of space policy and governance38:27 - Orbital highways and carrying capacities41:05 - Dependence on space infrastructure and its fragility45:14 - Privateer’s role in the evolving ecosystem46:52 - Democratizing space through data sharing49:45 - Can we undo the damage that’s been done?52:01 - Determining intent in space58:17 - Talent needed in the space industry1:01:04 - Privateer’s biggest challenges1:09:22 - Space stewardship and Hawaii’s kuleana1:15:19 - Who inspires Alex? Resources: Privateer’s website: https://mission.privateer.com/Privateer’s Wayfinder tool: https://mission.privateer.com/Privateer on Twitter: https://twitter.com/PrivateerSpaceSteve Wozniak on Twitter: https://twitter.com/stevewozAlex Fielding on Twitter: https://twitter.com/Alex__FieldingDr. Moriba Jah on Twitter: https://twitter.com/moribajah Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.com/podcastsFollow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Generative AI tools like DALL-E, Midjourney, and Stable Diffusion have taken the world by storm in recent months, wowing the masses with their uncanny ability to produce images via text prompts. In this interview, we’ll chat with Karen Cheng about how she’s leveraged these tools among others, with a focus on how this new paradigm is reshaping the creator landscape. You’ll get to hear the behind the scenes of many of her viral works, including a video of her becoming a lawnmower, her AI-generated Cosmo magazine cover, her DALL-E fashion show, her transforming iconic art into 3D museums to explore, and much, much more. By the end of this episode, listeners should have a better understanding of the new tools at their fingertips (literally!), how AI can indeed enhance the creative process, and the second-order effects of these innovations, like how creators are paid.Since we’re just at the beginning of the AI era, this is just the beginning of our coverage as well.Timestamps: 00:00 - Intro02:59 - Karen’s journey to content creator06:32 - Creative unlocks for viral content09:28 - The changing social media landscape12:08 - Innovating with AI14:59 - Unique AI tools available today17:52 - How AI tools might differentiate21:04 - Cosmo’s first AI-generated magazine cover24:19 - Inpainting, outpainting, and the fungibility of artists31:54 - AI enhancing the creative process32:39 - The virality of optimism vs pessimism38:19 - Turning attention into business43:13 - IP and ownership in the age of AI46:18 - The downward pricing pressure of AI47:21 - Is generative AI still a gimmick?53:32 - The adaptiveness of humans58:26 - The importance of AI ethics Resources:Karen’s TED TalkKaren’s Instagram accountKaren’s websiteCosmo magazine cover and tutorialDALL-E fashion show and tutorialDALL-E outpainting announcementI spent $15 in DALL·E 2 credits creating this AI image Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.com/podcastsFollow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

The long-standing (and chart-topping) a16z Podcast returns to cover the most important topics within the world of technology. Brought to you by the minds at Andreessen Horowitz (a16z) and hosted by Steph Smith, each episode goes beyond headlines, giving listeners insider access to the edge of innovation.Subscribe to be the first to receive upcoming episodes featuring industry leaders like Steve Wozniak, Marc Andreessen, Balaji Srinivasan, and Neal Stephenson, and covering a range of topics, from AI to space to the metaverse to genomics, and beyond. Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.com/podcastsFollow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

In this special episode from a16z’s Bio Eats World podcast, general partners Vijay Pande and Jon Lai join bio editorial lead Olivia Webb to discuss the intersection of games and health, including:  what constitutes a game, the “healthy dessert” problem, and the challenge of building a game that’s both fun and therapeutic.You can subscribe to Bio Eats World wherever you get your podcasts.

This week, we have a special episode for you, from our newest podcast, "web3 with a16z" . This episode features Chris Dixon – founding general partner of a16z crypto and former entrepreneur himself – and Kevin Rose – the co-founder of Proof Collective, as well as co-founder of Digg, former investor at GV, and longtime entrepreneur and podcaster.In this wide-ranging hallway-style conversation from web3 with a16z, these two veterans of both web2 and web3 movements go long on tech trends both in web3 and beyond, including NFTs and art; AI; the evolving roles of modding, copying, and copyrights on the internet; tech’s expansion from Silicon Valley to LA and New York; and more. Their discussion is not just a journey through time (long cycles of computing, web2 to web3) and place (LA, SF, NYC), but into "the age of wonders". Are we at the end of (computing) history, or the beginning?For more on the latest in web3 trends, be sure to subscribe to our podcast “web3 with a16z” (which is hosted by Sonal Choksi, the longtime former showrunner of this show) wherever you listen to your pods.

Audio is no longer just audio anymore -- podcasts now pull from new video platforms like TikTok and older ones like radio, user experience is growing and changing, and it's easier than ever to create audio content. Where do all these mediums converge and where do they diverge -- when it comes to user experience, product design, recommendations, discovery, and more?In this episode from October 2020, a16z general partner Connie Chan and Spotify’s chief R&D officer Gustav Söderström join host Sonal Choksi to discuss the past, present and future of audio. They dig into everything from what the past in radio can tell us about the future, what audio can and will borrow from mediums like video and platforms like TikTok, the role for more interactivity and increased use of tools like machine learning and AI, and more.

While building and shaping culture is as relevant as ever for startups and companies today, leaders have sought the answers to these questions for hundreds of years – and there is practical advice to be had by examining different cultures across time and around the globe.In this episode from December 2019, a16z co-founder Ben Horowitz sits down with host Sonal Choksi to talk about what actually makes up culture, whether in a company or any organization or team, as based on Ben’s best-selling book, What You Do is Who You Are. They discuss the idea of culture as code, the nuances of setting and changing a culture, and how to apply the principles of his book to startups, the tech industry and any company today.

Behind many great leaders, you’ll usually find a great mentor. The mentor-mentee relationship is often one of the most important and most fulfilling relationships people have, in both their careers and in their lives. So how do you find a mentor? What are different kinds of mentorship? And how can it help you break into an industry – or help others break in themselves?In this episode from July 2018, a16z co-founder Ben Horowitz discusses mentorship with his mentor, Silicon Valley pioneer Ken Coleman, and Ben’s mentee, Michel Feaster, founder of Usermind and now Chief Product Officer at Qualtrics. They begin with their personal journeys and share advice and frameworks for mentorship, leadership, and growing as a founder.

In this episode from October 2021, Michael Dell, founder and CEO of Dell Technologies and one of the longest serving founder-CEOs in the technology industry, joins a16z general partner Martin Casado, a16z co-founder Marc Andreessen, and host Sonal Choksi on the occasion of Michael’s book, Play Nice to Win: A CEO’s Journey from Founder to Leader. There are lots of challenges in being public while trying to innovate, and limits to being a private company as well; but it's rare to see a company go public then private then back to public again. As is the case with Dell Technologies, one of the largest tech companies -- which went private 2012-2013 and then also pulled off one of the most epic mergers of all time with Dell + EMC + VMWare 2015-2016 (and which we wrote about here at the time).Is there a method to the madness? How does one not just start, but keep, and transform, their company and business? Michael, Marc, Martin and Sonal debate these questions, as well as the impact of the cloud wars, how innovation happens when a company is private and when its public (something Michael knows well, having taken Dell public to private to back to public again), whether you can actually play nice to win as a leader, and more.

In this episode from February 2019, Jyoti Bansal, founding CEO of AppDynamics and co-founder of Unusual Ventures, joins a16z general partner Peter Levine, a16z partner Sateesh Talluri, and host Sonal Choksi to discuss how product and sales evolve together for enterprise go-to-market, including key milestones for both product development and marketing, frameworks for how to think about pre- to post-product market fit, the role of additional levers like services or pricing, and more.For the show transcript, you can go here.

This week, student loans are back in the news, with the administration's announcement of a plan to forgive student loan debt for certain kinds of borrowers. Outside of the specific policies, though, student loans are often the first of many big financial decisions that young people make as they begin to build credit history and join the labor force. So what role can technology play in serving this demographic's particular needs, now and into the future?In this episode from October 2020, Amira Yahyaoui, the founder and CEO of Mos, a platform that helps students with their banking needs, like getting financial aid for college, joins a16z general partner Anish Acharya, partner Seema Amble, and host Lauren Murrow to discuss fintech for Gen Z and millenials. They dig into some of the issues around student loans today, the underserved banking needs of this group, and how fintech can help younger consumers today as well as set them up for a better financial future.

Can you get better at decision-making with practice? Many founders, investors, and builders must make many critical decisions, big and small, every day, and improving the quality of your decision-making process can become a big competitive advantage. In this episode from October 2020, expert decision strategist, author and professional poker player, Annie Duke, joins a16z managing partner Jeff Jordan, to discuss some of the frameworks, strategies, and tactics for better decision-making by both individuals and organizations that she outlines in her second book, How to Decide. This was Annie’s second appearance on the podcast – she first joined a16z co-founder Marc Andreessen and host Sonal Chokshi to discuss her first book, Thinking in Bets, where they  went deep into how to frame taking risks and placing bets, especially in the context of innovation. You can read the full transcript of this episode here, and you can read the transcript of Annie's first episode on the a16z Podcast with Marc Andreessen here.

What can we learn from the evolution of open source communities and how might they be applied to online communities and the creator economy today? Author Nadia Asparouhova joins host Sonal Choksi to talk about Asparouhova's book, Working in Public: The Making and Maintenance of Open Source Software, from Stripe Press.They start with a  a taxonomy for communities, and then dig into how open source has changed over time, which learnings from open source do and don’t apply to new communities online, how communities intersect with the growing desire for more "high-shared context" groups and spaces (including even podcasts and newsletters), and more.

Whether it’s moderating a live panel discussion, managing your (virtual) All Hands meeting, or even guiding a cross-functional team to a decision in an important meeting, mastering the art of helping a group communicate is a critical skill for many of us.In this episode from November 2020, expert communications and presentations coach Matt Abrahams, who is also a lecturer at Stanford’s Graduate School of Business, sits down with Sonal Choksi to share frameworks, strategies and many concrete tips for how anyone can become a better moderator and facilitator. They cover everything from how to approach prep work (like, can you be too prepared?) and how to handle disruptions on the fly to the subtle differences between in-person and virtual events, the ways our own ticks can manifest before an audience, and more.

What does the success of TikTok's algorithmically-driven product tell us about the future of creators and the creator economy, product design, and innovation within video?In this cross-over archive episode from our tech news podcast, 16 Minutes on the News, we go deep into the what, why, and how of TikTok's algorithm, which lies at the heart of the product and drives its "creativity network effects." The conversation features Eugene Wei (former head of product at Hulu, Flipboard, and video at Oculus), in conversation with host Sonal Choksi. This episode originally aired in September 2020, when there was talk of U.S. ownership/partnership for the American version of TikTok, which is from Chinese company ByteDance.

In this episode from December 2018, Hennessy, currently the chairman of Alphabet as well as Turing Award-winning computer scientist, joins a16z co-founder Marc Andreessen, a16z general partner Martin Casado, and host Sonal Choksi for a wide-ranging conversation about moving from academia to startups, the history of Silicon Valley, the “Stanford model”, how to build enduring organizations, and more.Hennessy also co-founded startups, including one based on pioneering microprocessor architecture used in 99% of devices today (for which he and his collaborator won the prestigious Turing Award)... so what did it take to go from research/idea to industry/implementation? And  how has the overall relationship and "divide" between academia and industry shifted, especially as the tech industry itself has changed? Finally, in his book, Leading Matters, Hennessy shares some of the leadership principles he's learned, offering nuanced takes on topics like humility (needs ambition), empathy (without contravening fairness and reason), and others. What does it take to build not just tech, but a successful organization?

In this hallway-style conversation with a16z's Margit Wennmachers, longtime operating partner for Marketing, and Kim Milosevich, CMO for a16z crypto, open up the black box of crisis communications with Sonal Choksi and explore the process and mindsets before, during, and after a crisis.They discuss common FAQs like: What constitutes a crisis? Can someone inside a company "call it" early and prevent a crisis from becoming a bigger deal? How do you respond when there's a lag or too much time between acknowledging the issue and finding out all the facts? Who should be in the (war) room ? Should you share the off-the-record background story with reporters? How do you know when a crisis begins and ends -- or that you're ready for a "comeback" story? We explore all this and more.

Over the last 20 years, the idea of “designing biology” has gone from science fiction to just science, as the field of synthetic biology has exploded, with applications from therapeutics to manufacturing and more. In this episode from January 2019, one of the pioneers in the field, professor James J. Collins of MIT, joins a16z general partner on the Bio + Health fund, Vijay Pande, and editorial partner Hanne Winarsky, to discuss the origins of synthetic biology or "synbio", to what "engineering and designing" biology really looks like in action and the disciplinary differences between how biologists and engineers see the world.

In this episode from July 2019, Kurt House, CEO and co-founder of Kobold Metals, John Thompson, professor of earth and geosciences at Cornell; and Connie Chan, a16z general partner for consumer, talk with editorial partner Hanne Winarsky about the way technology is transforming how we find cobalt, and the mining industry as a whole, as well as the science behind why cobalt is so critical for batteries, the data and knowledge behind mining today vs the past, and more.

In this episode from October 2019, People.AI founder and CEO Oleg Rogynskyy and a16z partner Peter Lauten discuss with Das Rush about what the rise of AI in B2B means for enterprises, workers, and startups. They explain why AI provides a strong first mover advantage to enterprises that adopt it early; how it can automate lower level tasks, maximize our focus, and, ultimately, make our work more meaningful; and for startups, they provide a playbook for seizing the next AI opportunity.To learn more about the latest in AI, ML, data, and how enterprise are working with these technologies, go to future.com/data.

In this episode from October 2019, a16z co-founder Marc Andreessen and former a16z podcast showrunner Sonal Choksi bring on MIT economist and bestselling author Andrew McAfee to discuss why the lessons of human growth in times past, from the Industrial Revolution onwards, might not apply to our future. It used to be that the only way for humanity to grow — and progress — was through destroying the environment. But is this interplay between human growth vs. environment really a zero-sum game? Even if it were true in history, is it true today? If capitalism is not responsible for environmental degradation, than who or what is? And where does (and doesn’t) technology come in?The conversation is based on McAfee’s 2019 book More from Less: The Surprising Story of How We Learned to Prosper Using Fewer Resources -- and What Happens Next,  ranging broadly across many areas of growth, from the future of energy and agriculture to the role of capitalism and technology today and tomorrow, from dematerialization  to Tesla, Buckminster Fuller, and more.

Blockchain, crypto, web3 – these terms get thrown around a lot and sometimes interchangeably, but what are the actual connections between them? And what are some mental models and analogies for thinking about this blossoming area of computer science?To dig in on these topics and more, we have another crossover episode this week, part of our occasional series where we share curated episodes from other shows that we think you’ll enjoy.This time, we’re featuring one of the first episodes from "web3 with a16z", a new show which just launched last week. Hosted by Sonal Choksi and featuring the team at a16z crypto as well as leading scientists and makers in the space, this show is about the next generation of the internet, how builders and users now have the ability to "own" pieces of the internet, unlocking a new wave of creativity and entrepreneurship. This episode features a16z crypto general partners Chris Dixon and Ali Yahya, and Tim Roughgarden, head of research at a16z crypto, in conversation with Sonal Choksi.

In this special “innovation overview” episode from April 2021, the a16z crypto team and other experts take you from the ground up of crypto and web3 — from the basics, to more recent developments, and beyond – through the lens of an oral essay with brief segments on what crypto is, how it really works, and where it’s going.We chose this particular archive episode this week in honor of a new show that just launched: web3 with a16z. Hosted by Sonal Choksi, the previous showrunner of the a16z podcast network and longtime host of this show, and featuring the team at a16z crypto as well as leading scientists and makers in the space, this show is about the next generation of the internet, how builders and users now have the ability to "own" (web3) pieces of the internet, unlocking a new wave of creativity and entrepreneurship. The first two episodes are out this week, so check out and subscribe to “web3 with a16z” wherever you get your podcasts.

In this episode from February 2017, a16z co-founder Ben Horowitz and Jason Rosenthal, former Lytro CEO (now Vice President, Subscription Services, at Google) share stories and lessons learned from doing whatever they could to help their companies survive in hard times, including making and living through major pivots, selling new products before they were ready, figuring out financing with market and industry headwinds against them, and more. From their days together at LoudCloud to Jason’s experience at Lytro, and beyond, a common theme emerges: a CEO’s job is lonely in these moments and the hardest thing about a big pivot or change might be in finding the courage to make the decision in the first place.

In this episode from February 2021, early Amazon execs Colin Bryar and Bill Carr -- in conversation with a16z's Sonal Chokshi -- go beyond the well-known artifacts of Amazon innovation, like the memo and the press release, and share the leadership principles, decision making practices, and operational processes that helped Amazon continue to innovate, invent new products and learn from its mistakes, as it scaled. It’s all based on their book, Working Backwards: Insights, Stories, and Secrets from Inside Amazon, drawing from the 27 years combined experience of being in the room where it happened at Amazon.

Gross margins–which are essentially a company’s revenue from products and services minus the costs to deliver those products and services to customers–are one of the most important financial metrics for any startup and growing business. And yet, figuring out what goes into the “cost” for delivering products and services is not as simple as it may sound, particularly for high-growth software businesses that might use emerging business models or be leveraging new technology. In this episode from June 2020, a16z general partners Martin Casado, David George, and Sarah Wang talk all things gross margins, from early to late stage. Why do gross margins matter? When do they matter during a company’s growth? And how do you use them to plan for the future? The conversation ranges from the nuances of and strategy for calculating margins with things like cloud costs, freemium users, or implementation costs, to the impact margins can have on valuations.

This week, we have a special crossover episode from June 2021: Joel Beasley, host of the Modern CTO podcast, interviews a16z general partner David Ulevitch about David’s journey from working at an ISP and Dot Com company mp3.com in high school; to starting, running, and selling his own enterprise security company, OpenDNS; to becoming an investor at a16z. They also discuss the value of product marketing for enterprise, David’s philosophy around pricing enterprise products how to survive and lead through hard times, new trends in startup investing, and more. This is part of our occasional series where we feature relevant episodes from like-minded shows on the a16z Podcast, to surface other shows you might be interested in. The Modern CTO podcast is by and for CTOs and other technical leaders at places like Microsoft, NASA, Reddit, Launch Darkly, and more, all sharing how to build strong companies and organizations. It’s hosted by Joel Beasley, CTO of Leaderbits and author of the book, The Modern CTO. Check out more episodes of this show wherever you get your podcast. And for more on how to grow from a technical to product to Sales CEO, check out David’s previous episode on this podcast called “What Time Is It”.

In this wide-ranging conversation from April 2019, a16z’s Frank Chen sits down with Ken Kocienda, a longtime software engineer and designer at Apple from 2001 to 2017, who wrote a book about his career there, called Creative Selection.They discuss Ken’s unconventional path from freelance photographer to software engineer at Apple, his work on many core products from Safari web browser to iPhone, iPad, and Apple Watch and features like Autocorrect, what it was like to demo new products for Steve Jobs, and more.

In this re-run from September 2018, Benedict Evans and Steven Sinofsky talk all about Tesla — and more broadly, the nature of disruption overall. How disruptive is Tesla really, and what exactly are they disrupting — from the dashboard to car makers to vendors to energy source to autonomy overall?The tech industry is littered with leading innovators... who nonetheless failed to be the dominant leader in the end. So the question should be, is this new thing fundamentally difficult for the incumbent to do, and how does it relate to market dominance? Which of these things are important in order for Tesla to be the new BMW or the new GM? Looking back at other examples historically (Microsoft, GM's Saturn Brand, and of course the iPhone), what kind of disruption matters most for market dominance? And what is the long view of how software is eating transportation?

In this episode from September 2020, originally recorded for the Commonwealth Club of California, Netflix CEO and co-founder Reed Hasting talks about his new book "No Rules Rules: Netflix and the Culture of Reinvention" with a16z co-founder and fellow author Ben Horowitz, who also wrote a bestselling book about culture in 2019. During the conversation, Reed tells the story of Netflix's evolution and his management philosophy, including the hard lesson he learned about what happens when you optimize for efficiency at the expense of creative talent. He also explains why sometimes a more narrow market focus is better for growth and shares the tactics that have helped Netflix expand globally and translate a culture of innovation across different countries, from Japan to Brazil to America.

After achieving product-market fit and starting to gain users, how do startups then avoid the "leaky bucket" problem of losing users as quickly as they gained them? By focusing on user engagement and retention, startups can not only keep their hard-won customers but also ensure that each new cohort of users gets more and more value out of their product.This episode is part two in a two-part series on the basics of growth. Featuring a16z general partners Andrew Chen (formerly of Uber and author of the book, The Cold Start Problem) and Jeff Jordan (formerly of OpenTable, eBay, Disney, and more), in conversation with Sonal Chokshi, the conversation goes deep on many aspects and nuances of engaging and retaining users: from how network effects come into play and if there is really a magic number or "aha" moment for a product to who are the power users and the power user curve for measuring, finding, and retaining those users.For a deeper discussion on user acquisition, check out last week's episode, the first part of this series.

Once known as “growth hacking”, the concept of Growth has now evolved into an entire discipline that spans marketing, product management, user experience, and more. Why? After achieving product-market fit, startups need to capitalize quickly on that initial traction to capture and retain more users and market share before the competition does, and building an efficient and resilient growth strategy is a critical component.This episode -- one of two in a series -- focuses on the user acquisition aspect of growth. Featuring a16z general partners Andrew Chen (formerly of Uber and author of the book, The Cold Start Problem) and Jeff Jordan (formerly of OpenTable, eBay, Disney, and more), in conversation with Sonal Chokshi, the discussion also covers the nuances of paid vs. organic marketing (and the perils of blended CAC); the role of network effects; where does customer lifetime value (LTV) come in; and much more. Because at the end of the day, businesses don't grow themselves.

Over a decade after the idea of “big data'' was first born, data has become the central nervous system for decision-making in organizations of all sizes. But the modern data stack is evolving and which infrastructure trends and technologies will ultimately win out remains to be decided.In this podcast, originally recorded as part of Fivetran's Modern Data Stack conference, five leaders in data infrastructure debate that question: a16z general partner and pioneer of software defined networking Martin Casado, former CEO of Snowflake Bob Muglia; Michelle Ufford, founder and CEO of Noteable; Tristan Handy, founder of Fishtown Analytics and leader of the open source project dbt; and Fivetran founder George Fraser.The conversation covers the future of data lakes, the new use cases for the modern data stack, data mesh and whether decentralization of teams and tools is the future, and how low we actually need to go with latency. And while the topic of debate is the modern data stack, the themes and differing perspectives strike at the heart of an even bigger: how does technology evolve in complex enterprise environments? We're re-running this episode as part of a special report on Future.com, the Data50: the World's Top Data Startups, which covers the bellwether private companies across the most exciting categories in data, from AI/ML to observability and more.

In the face of great uncertainty, how do you make decisions? Can you really apply the lessons of the past to the present and the future, to navigate seemingly new situations and get what you want out of business and life? By deeply understanding cause-effect relationships -- clearly expressed, shared with others, overlaid with data, back-tested, modified -- you can build a set of principles for dealing with the realities of whatever situation you're in, observes Ray Dalio, in this episode from 2018 and in conversation with a16z's  Alex Rampell and Sonal Chokshi, Dalio's book Principles: Life and Work originated as an internal company document that was posted online years ago and has been shared widely since. His insights on how to create your own recipe book to draw upon in moments of great change is as relevant as ever. The conversation covers everything from the differences between private and public investing, and between startups and big companies -- to questions of getting timing right, how people, teams, organizations, and even nation-states can evolve through principles like "believability-weighted idea meritocracies," and more.

In his book (and podcast), Brian McCullough chronicles the history and evolution of the internet -- from college kids in a basement and the dot-com boom, to the applications built on top of it and the entrepreneurs behind them.General partner Chris Dixon chats with McCullough about How the Internet Happened -- and more broadly, about how tech adoption and innovation happens. They discuss lessons learned, how innovation doesn’t happen in a straight line, and what the past can tell us about the next phase of the internet and technology.

original episode notes and transcript here: https://future.a16z.com/podcasts/textiles-technology-science-math-cultures-civilization/Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. The third of these three special rerun episodes is a conversation that originally took place in October 2020, in the midst of the pandemic – and perfectly captures the signature identity of this show until now, and Chokshi's work, which is at the intersection of technology and humanity. In it, she and Virginia Postrel, author of the book The Fabric of Civilization: How Textiles Made the World cover everything from science and math across several fields, to commerce to management & measurement, to the always-meta narrative of HOW innovation happens… As a reminder: the a16z marketing & Future team will be putting this feed on hiatus while they relaunch it with a new host; in the meantime, you can continue to follow Sonal's work both here at a16z and other projects on Twitter @smc90. Thank you as well to our brilliant audio editors, expert guests, and several others here -- but most of all, thank you to YOU: for listening, sharing, engaging, and coming along with us on this journey the past decade! Stay tuned for more.

original episode notes and transcript here: https://future.a16z.com/podcasts/innovating-in-bets/Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. The second of these three special rerun episodes is a conversation that originally took place spring/summer 2019, pre-pandemic (ah, that we could remember that time!) – between a16z co-founder Marc Andreessen and Sonal interviewing author, consultant/advisor, and former pro poker player Annie Duke, on one of her first few appearances with us. It’s a conversation quite unlike her other conversations, and one in a series of special joint interviews Marc and Sonal did. So there's a lot of high-speed talking, but the three cover a broad range of topics relevant to both businesses and individuals: on skill vs luck, on outcomes vs process, on asking the right questions, on how to communicate in probabilities within an organization or team, and, on how NOT making a decision is also a decision and why that matters. Be sure to also check out this feed for the followup conversation with Annie, Jeff Jordan, and Sonal on the specifics of HOW to Decide as well -- the practical and organizational implementations. (Because the a16z Podcast became an early go-to for book authors to release their books, Annie agreed to share her next book with us first.) But overall, these evergreen episodes are really all about INNOVATION, which is another signature theme in defining the identity of the a16z Podcast…

original episode notes and transcript here: https://future.a16z.com/podcasts/pleistocenepark-geoengineering-iceagebiome/Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. The first of these three special rerun episodes is a conversation that originally took place in summer 2017, but both the work discussed in here – on making a really wild (quite literally wild;) geo-engineering idea at massive scale real – is still actively, relevant, and frequently discussed today (it’s on bringing back lab-grown woolly mammoths, which was also discussed in the 2020 documentary with Stewart Brand, We Are As Gods). But it's also all about how we humans can and do use the power of narrative to drive great feats of change, including engineering. This has been a signature theme in forming the identity of the a16z Podcast, and the conversation that follows is one that takes place among three tech & science editors, including one of our former colleagues (who also was a host on this podcast for 4 years).links: https://www.theatlantic.com/magazine/archive/2017/04/pleistocene-park/517779/https://www.weareasgods.film/

Welcome to the a16z podcast. Today we’re talking about the mindsets and frameworks founders should know about when navigating the mergers and acquisitions or M&A process, both before and after – including how to think about the pricing dynamics, factors that go into the decision-making process, and what to expect from the integration once the deal is done.A16z editorial partner Zoran Basich recently talked to two a16z experts here to give us their big-picture view of the most important things to know – for founders seeking to acquire companies and how they might think about it, or those considering selling a company, or just those deciding to merge with an acquirer.Blake Kim is a partner on our Enterprise Network team and a former investment banker who works with companies on strategic partnerships; he also recently co-wrote a post on Future outlining all the different exit options and considerations for companies. And general partner Martin Casado discusses common M&A issues and shares his experiences both as observer and participant – including the challenges of integration, which he saw from the inside with Nicira, which he cofounded and was acquired by VMware for $1.26 billion in 2012, and where he remained for years to lead its networking and security business unit.As a reminder, none of the following should be taken as investment advice. Please see a16z.com/disclosures for more important information.They start the discussion by outlining the frameworks for understanding M&A dynamics, including the “kingmaking dynamic” and the difference between “selling your company” and “getting acquired.”

Innovation in the data center has been constrained by the traditional model of suppliers providing fixed-function chips that limit how much the biggest data center operators can differentiate. But programmable chips have emerged that allow these companies to not only increase performance, but innovate throughout the pipeline, from operating system to networking interface to user application.This is a major trend among "hyperscalers," which are some of the world’s most well known companies running massive data centers with tens of thousands of servers. We’re talking about companies like Amazon, Facebook, Microsoft, Google, Apple, Alibaba, Tencent.To talk about the trends in data centers and how software may be “eating the world of the data center,” we talked this summer to two experts. Martin Casado is an a16z general partner focused on enterprise investing. Before that he was a pioneer in the software-defined networking movement and the cofounder of Nicira, which was acquired by VMWare. (Martin has written frequently on infrastructure and data-center issues and has appeared on many a16z podcasts on these topics.)He’s joined by Nick McKeown, a Stanford professor of computer science who has founded multiple companies (and was Martin’s cofounder at Nicira) and has worked with hyperscalers to innovate within their data centers. After this podcast was recorded, Nick was appointed Senior Vice President and General Manager of a new Intel organization, the Network and Edge Group. We begin with Nick, talking about the sheer scale of data-center traffic.

What are network effects? [1:32]How do you cold start and get your first users? [2:33]Atomic networks and why minimum viable community is more important than minimum viable product [6:36]How do you curate your network and set norms? [8:42]Faking users: good idea, bad idea? [13:13]What is flintstoning? [14:26]How does the relationship to creators change as you scale? [17:07]Building for the professional creator class [22:52]How is web3 changing incentives? [25:12]

Given all the activity and interest recently around crypto and web3, as well as in upcoming holidays and art events, we’re re-running our episode all about NFTs (from March 2021) -- where we covered everything you need or want to know about NFTs. You can also find a curated list of resources to learn all about NFTs at future.com/nftcanon. That list, and this episode, has something for everyone -- from artists and creators and other builders to big companies and institutions or just anyone seeking to understand or even explain to others NFTs.Here, we’ve cut through the noise around NFTs to share the signal, covering everything from: what NFTs are and the underlying crypto big picture, before we dig into specifically what forms they take;common myths and misconceptions -- from confusing overlaps with other concepts to addressing commentary like it’s “just a JPG” or that it’s just hypeto the question of energy use, also covering briefly how NFTs workproviding a quick overview of the players/ ecosystemand throughout, covering various applications too.Joining host Sonal Chokshi are Jesse Walden, now of Variant Fund, and formerly co-founder of Mediachain Labs, which was acquired by Spotify; and Linda Xie, now of Scalar Capital, and formerly an early product manager at Coinbase. As a reminder, NONE of the following should be taken as investment advice, for more important information please see a16z.com/disclosures.[If you’re also interested in DAOs (which we touch on briefly in this episode), we just recently published a list of readings -- in the vein of our famous crypto canon resource, then NFT canon, and now DAO canon -- all about DAOs. It’s for anyone seeking to understand, build, and otherwise get involved with these “decentralized autonomous organizations” -- which represent the future of community, coordination, work, and much more… so we’ve curated resources on this list for people at different levels of interest, from dipping one’s toes in to going deep. You can find that at future.com/daocanon.]This episode was originally released in March 2021: https://future.a16z.com/podcasts/nfts-explainer/

In today's episode we’re talking about an emerging model of gaming called play to earn, in which players can make actual money based on how much time and effort they put into a game. Play to earn is also part of broader trends — the changing relationship between players and platforms, new incentives for participants in blockchain-based networks, and the new internet era that is coming to be known as a web3. The top play-to-earn game is called Axie Infinity, operated by a Vietnam-based company called Sky Mavis. Players of the game acquire unique digital pets called Axies, and battle other teams of Axies. These NFT Axies can be created and sold using the game’s in-game currency, SLP, which can be traded for traditional currency. Think of it as Pokemon on the blockchain, with a social network built-in, and an actual economy, and even companies built around the game that help players onboard and loan them money to get started playing. The game has made more than $3 billion in total sales since launching in March 2018, with much of its early growth in the Philippines. (As a reminder, none of the following should be taken as investment advice, please see a16z.com/disclosures for more important information.) Our guests today are Jeff Zirlin, the cofounder of Sky Mavis; Gabby Dizon, the cofounder of Yield Guild Games, a play to earn gaming guild that gives players the resources to start playing; and a16z crypto general partner Arianna Simpson. They talk to a16z's Zoran Basich about the tech trends that enabled the emergence of play to earn, why and where it caught on first, and the role of community, as well as the challenges, which include onboarding and scalability, and the economic sustainability of this model. The panel also discusses what the play-to-earn movement say about the future of work.

"Beyond the Meme: Ever Given, Supply Chains, and the Physical World" -- by Ryan Petersen (June 2021). Bio + essay details/ originally appeared at: https://future.a16z.com/beyond-the-meme-ever-given-supply-chains-and-the-physical-world/More read-alouds at: https://a16z.com/tag/read-alouds/

Today’s episode is all about crypto security — that is, the new mindsets and the new strategies for storing crypto assets safely while also allowing holders control and access. As a reminder, none of the following should be taken as investment advice, please see a16z.com/disclosures for more important information. We’ve covered security trends more broadly a ton in our content, which you can find at a16z.com/security, as well as crypto-related trends including NFTs, and the creator and ownership economies; you can find all of that at a16z.com/nfts But as more people enter crypto lately — thanks to the boom in NFTs, decentralized finance, and much more — we share specific best practices and options for securing crypto as well as discussing how it all fits this next evolution of the internet: web3. Our expert today is a16z crypto data scientist Eddy Lazzarin, who joins host Zoran Basich to cover practical approaches ranging from passwords to crypto wallets and what users can do; the evolution of crypto briefly; and the big picture mindset shifts involved here as well. We quickly begin with the practical shift crypto security represents compared to how people interact with traditional financial institutions, and then we go into the big picture trends in security when it comes to abstraction and usability.

There are lots of challenges in being public while trying to innovate, and limits to being a private company as well; but it's rare to see a company go public then private then back to public again. As is the case with Dell Technologies, one of the largest tech companies -- which went private 2012-2013 and then also pulled off one of the most epic mergers of all time with Dell + EMC + VMWare 2015-2016 (and which we wrote about here at the time).Is there a method to the madness? How does one not just start, but keep, and transform, their company and business? Especially as it adapts to broader, underlying tech platform shifts. Michael Dell shares all this in his upcoming new book, Play Nice to Win: A CEO's Journey from Founder to Leader... he also, tellingly, may be one of the longest-standing founder-CEOs (37 years so far).Because this is really a story about innovation, who decides, who judges, who does it, and where: In the markets, in public, in private; in the both the big picture and the inner detailed workings of a business beyond "cells in a spreadsheet"; and even in fighting -- or harnessing! -- narratives, whether it's the demise-of-PC or cloud wars 1.0 /2.0... And where trends like the cost paradox of cloud, and "end of cloud" edge computing, among others like AI & ML, also come in. In this special book-launch episode of the a16z Podcast with Marc Andreessen, Martin Casado, and Sonal Chokshi debate the Cloud Wars to the Company Wars (along with some behind-scenes stories and even some star wars) with Michael Dell... and whether you can really play nice to win. image: Dell EMC World 2016/ © Dell Inc. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

There's no question technology played a huge role in the recent/current pandemic, including especially in the plug-and-play engineering and incredibly fast development behind the mRNA vaccines... But is there an even bigger role for the private sector, not just government, to play (and partner) when it comes to key infrastructure for future such emergencies, and even beyond?Especially given how faulty the translation of institutional science to policy and public health measures turned out to be -- for instance, with "6 feet" of social distancing, or with fomite (vs. aerosol) transmission of COVID. And why are we still talking about the same, not specific, vaccine booster for the Delta variant? What can we learn about real-world evidence, other clinical trial approaches, and progressive (vs. binary) EUA approvals when it comes to public health emergencies? Are capabilities like genomic surveillance and mapping strains -- which require layers of technology, real time -- sitting in the right places?In this special book-launch episode of the a16z Podcast, former FDA commissioner Dr. Scott Gottlieb -- author of the upcoming new book, Uncontrolled Spread: Why COVID-19 Crushed Us, and How We Can Defeat the Next Pandemic -- shares insights on the above, and revealing stories from behind the scenes. Do we need a new entity to manage public health through a national security lens, and is the government capable? Gottlieb debates this and other probing questions from a16z co-founder Marc Andreessen (who famously wrote "It's time to build"); a16z bio general partner Vineeta Agarwala MD, Phd (who has spoken about the trials of clinical trials, practiced medicine during the pandemic, and more); and founding a16z bio general partner Vijay Pande PhD (who, among other things, founded the distributed computing project Folding@Home which pivoted to COVID proteins).One thing's for sure -- with this COVID crisis, we're at an inflection point between old and new technology -- whether it's in how we make vaccines, or how we apply the fields of synthetic biology and genetic epidemiology in public health response. So now's the time to look both backward, and forward, to really change things...

There's been a false dichotomy in technology and management lore over the past decade, between "brain" and "brawn", digital and physical, independence and interdependence, software culture versus industrial culture… or so observes Stanford Graduate School of Business lecturer, former big-company executive, and startup founder Robert Siegel in his new book, The Brains and Brawn Company: How leading organizations blend the best of digital and physical.Whether you're an early startup or a Fortune 500 company, we live in an increasingly complex world -- which means embracing digitization is not enough. But logistics, supply chains, and infrastructure are messy, ugly, and hard. So today's leaders have to think completely differently, in terms of ecosystems; and they're often in the position of having to influence but not have control. So when and how do they assert power in an ecosystem? When do they try to shape it? When do they sit back? What to do if their channel partner suddenly changes? When do you want to stay frenemies and when do you wanna be enemies? These are just some of the hard questions companies today have to wrestle with... All boiling down to when and where to partner, when to go it alone?So in this hallway-style discussion among Siegel and fellow Stanford b-school lecturers Jeffrey Immelt (former CEO of GE) and a16z general partner Jeff Jordan -- in conversation with host Sonal Chokshi -- the group wrestles with these questions, spinning through several different company examples such as Instacart and Stripe to Apple and Android/Google to Disney, Peloton, and others. But we talk too much about the outliers; we need to also talk more about the tools, and mindsets, that leaders of all kinds -- not just the once-in-a-generation leaders! -- can use. After all, argues Siegel, "Incumbents are not doomed and disruptors are not ordained." The views expressed here are those of the AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Recently, a16z and the Stanford Center for Blockchain Research hosted the NFT Virtual Summit, which brought together leading thinkers and builders on the topic of NFTs, or non-fungible tokens — these tokens are enabling new creator and ownership economies to emerge. We’ve covered NFTs in other podcasts and articles, including a curated list of reading resources, and you can watch all the videos from the summit. Today we’re sharing one of the discussions from that virtual summit (all of which were also published on our a16z Live feed) — this episode features General Partner Katie Haun chatting with Devin Finzer, cofounder of NFT marketplace OpenSea, on the topic of NFT “Use Cases, Today, and Tomorrow” — they cover the "tokenization of everything."###The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five.So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- Rajeev Venkayya of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and what's left to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease?Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been nearly a century in the making.

This is a special episode of the a16z podcast — it's an audio history, told through the voices of the a16z crypto team, about what crypto is, how it really works, and why it matters. This "innovation overview" is meant as a resource, and it features hallway-style conversations with the a16z team as well as outside experts.In brief segments, we’ll take you from the ground up — from the basics, to the most current developments, and beyond that to a look at what we might see in the future. Here are the topics and voices you'll hear:The BeginningIntroduction — Zoran Basich, a16z crypto editorBefore bitcoin: previous attempts to create digital money, 1:45 — Dan Boneh, computer science professor at Stanford and a16 advisor The core innovations of Satoshi’s white paper, 3:36 — Dan Boneh Proof of work, 5:36 — Alex Pruden, chief strategy officer at Aleo Systems and former a16z crypto partner Mining and why it’s important, 7:10 — Alex Pruden The history of mining, 8:20 — Alex Pruden Value in monetary systems, or why bitcoin is worth anything, 9:53 — Arianna Simpson, a16z crypto partner Bitcoin as store of value, 11:30 — Arianna Simpson Security in crypto, 12:45 — Alex Pruden ExpansionWhy is it called a blockchain? 14:00 — Eddy Lazzarin, a16z data scientist Why the blockchain matters and what you can do with it, 15:09 — Chris Dixon, a16z general partner Beyond bitcoin, 17:01 — Eddy Lazzarin Ethereum as logical extension of open source, 17:36 — Eddy Lazzarin Tokens: What are they? 19:04 — Eddy Lazzarin Tokens and the functions they serve, 19:53 — Scott Kupor, a16z managing partnerTokens and the ownership economy, 21:19 — Jesse Walden, Variant Fund founder, former a16z partner, and Mediachain founder What tokens enable for creators, 22:18 — Ali Yahya, a16z general partner Right NowWhat DeFi means, 23:58 — Eddy Lazzarin Yield farming: What is it? 25:16 — Eddy Lazzarin NFTs: What they are and why they matter, 27:15 — Linda Xie, Scalar Capital managing director, and Jesse Walden Developer ecosystems, crypto, and composability, 30:17 — Jesse Walden Decentralized networks, value capture, and what it means for builders, 33:05 — Ali Yahya The FutureThe big picture, web3, and DAOs, 35:38 — Chris Dixon For more crypto resources, please see our Crypto Startup School page, our documentary about the program, and our NFT Canon.###The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

It's clear from the growth of Patreon, Substack, TikTok, Clubhouse and many more that the power of the Creator Economy continues to build. These platforms share one thing in common: They all enable independent creators to monetize their skills and products like never before. It's a trend that’s become increasingly relevant as the demand for virtual work grows.In this episode, first published a year ago, Patreon cofounder Sam Yam, Atelier Ventures' Li Jin (formerly a16z), and host Lauren Murrow discuss monetizing community, why creators today are effectively making more money off fewer fans, and what all of this means for the future of work.The discussion is based on The Passion Economy and the Future of Work, a popular essay that first ran on a16z.com in October 2019. Check out that post and more creator content at:  a16z.com/creatoreconomy.

In today’s episode of the a16z Podcast, we’re talking about the Creator Economy, and how NFTs (but not just NFTS!) are making it possible for artists, musicians, videogamers, game developers, and writers to create entirely new markets to make money from their work and engage with their fans.Part of this emerging picture is social tokens, which share a crypto foundation with NFTs, but unlike NFTs (which are non-fungible tokens, in which each token is unique), social tokens are typically fungible, meaning each token has the same value. (Listen to our explainer episode "All About NFTs" with Sonal Choksi, Jesse Walden, and Linda Xie, or see our curated NFT Canon for much more info on NFTs!)This hallway-style chat features a16z General Partner and crypto investor Chris Dixon, talking with Kevin Chou, who founded Kabam, and is the founder of Rally, an open network on Ethereum where creators can launch social tokens; and Jesse Walden, the founder of MediaChain, a music rights protocol that was acquired by Spotify; he’s now the founder of crypto venture fund Variant.They’ll talk about how musicians, artists, and writers can think about NFTs and social tokens as well, and how those different types of assets can interact to create models that haven’t existed before.But Chris starts off the discussion by talking about the emergence of crypto tokens, and a look at how videogames and gamers were early to the idea of community engagement and digital assets, and how that model is beginning to spread outward.

This episode is all about NFTs. It seems like nothing has caught on and spread into mainstream interest like NFTs, where one hears everything from "I've never seen anything like this before" to "is this like ICOs all over again" to "it's just a jpg I don't get it" to "but what about the energy use!"So, in this special deep-dive episode from the a16z Podcast network, we break down everything you need or want to know about NFTs -- while cutting through the noise for what’s hype/ what’s real, as well as where are on the long arc (and sometimes seemingly sudden tipping point!) of innovation (apparently, Google trends data showed that interest in NFTs recently surpassed interest in cryptocurrency). Editor in chief Sonal Chokshi interviews friends of a16z crypto Linda Xie, co-founder of Scalar Capital and former Product Manager at Coinbase; and Jesse Walden, founder at Variant Fund and former co-founder of Mediachain Labs (which was acquired by Spotify, where he was then an R&D lead).Posted on both the a16z Podcast show and 16 Minutes -- as one of our "2-3x explainer episodes" of topics that keep coming up over and over again in the news (past such episodes have covered everything from Section 230 and Tiktok to GPT-3 and the opioid crisis) -- this episode covers:what NFTs (non-fungible tokens) are -- as well as the properties of crypto that enable them, just to set some big-picture context;what forms they take, and what is and ISN’T an NFT -- including where “social tokens” and the creator economy do and don’t come in;common myths and misconceptions -- from ‘just a jpg’ to the frequent question of energy use & NFTs;how they work -- as well as the broader ecosystem around NFTs, and different players;various applications, now and next -- touching briefly on how to think about NFTs, whether you’re an artist/ creator, developer, or institution....This episode is for everyone!transcript available at: https://a16z.com/2021/03/27/nfts-explainer-faqs-hype-reality-innovation-crypto-creator-economyimage: Mona Lisa/ Creative Commons 4.0; changes made by Greg Truesdell per Sonal Chokshi, who dubbed it "The First 500 Years" as a nod to Beeple's "The First 5000 Days"The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

In the tech world, marketplaces are a hot topic. That term—marketplace—encompasses a huge swath of services we use every day, from grocery delivery to online shopping to remote learning. How have marketplace dynamics changed since pre-pandemic, and what COVID-propelled consumer behaviors will persist into 2021 and beyond?  In this episode, we discuss the most promising marketplace companies and categories on the rise, based on data from the Marketplace 100, a ranking of the largest and fastest-growing consumer-facing marketplace startups and private companies.The report provides rich fodder for looking ahead at the future of marketplaces: Which companies are on a tear and which are locked in close competition? Which marketplace categories are poised for growth, and which may make a comeback? Host Lauren Murrow is joined by a16z consumer team partners Connie Chan, D’Arcy Coolican, Jeff Jordan, and Sriram Krishnan.

https://a16z.com/2021/03/15/16-minutes-58-the-johnson-johnson-vaccine-and-covid-efficacy-rates/

This podcast -- which was recorded at the Computer History Museum in a live event, before the pandemic (first published in December 2019) is all about how companies create culture: A lot's changed... and a lot hasn't. a16z editor in chief Sonal Chokshi interviews a16z co-founder Ben Horowitz -- author of the book What You Do Is Who You Are -- on whether companies and people can change; how the very thing that is your strength can also be your weakness; how startups evolve from pirates to the navy; actions vs words and values; and more. The discussion also covers common tropes that often come up in Silicon Valley folklore -- whether it’s “fake it til you make it” and the “reality distortion fields” of visionaries… vs. liars. Drawing on historical themes and examples from a thousand years ago to today -- spanning empires, wars, revolutions, hip-hop, and prisons -- the discussion covers key themes and nuances, as well as practical advice, on creating company culture. Please note -- especially if you’re listening on smart speakers at home with children or with kids in a car -- that the discussion that follows includes various mentions of violence.  100% of the proceeds of the book go to anti-recidivism as well as towards helping Haiti.   Nick Quah, writer and publisher of Hot Pod (also at Vulture) joins a16z general partner Connie Chan -- and editor in chief (and showrunner of the a16z Podcast) Sonal Chokshi -- to talk about all this and more in this hallway-style jam.

Boss Talk is a  weekly live show on Clubhouse, where a16z cofounder Ben Horowitz and Databricks CEO Ali Ghodsi discuss CEO stuff, leadership stuff, management stuff… you know, boss stuff. Here we share the second installment; in it, they explain Conway’s Law and shipping your org chart; how to transition from a boss to a boss of bosses; and their predictions for Silicon Valley post-pandemic.For more episodes of Boss Talk and other conversations from a16z, check out our separate feed, a16z Live.

In just the last couple years, ransomware has grown into a multibillion dollar industry. It has evolved from taking systems and servers hostage to stealing data, and it has proven capable of shutting down global organizations. In recent months, ransomware groups directly shut down Kia Motors North American IT systems; indirectly may have contributed to the death of a patient due to hospital ransomware; and allegedly stole sensitive files from a law firm whose clients include former President Trump.In this explainer episode, Tom Hofmann, the SVP of Intelligence at Flashpoint Intel (which monitors ransomware criminal syndicates and assists organizations with prevention and response) and a16z security operating partner cover: how ransomware works, from the anatomy of a hack to how the groups operate; the role of nation-states, insurers, and regulators; and what to do if your stuff is taken hostage.For more on cybersecurity, check out our coverage of organized cybercrime and hacks and our 16 step guide to protecting your data.

On social audio app Clubhouse, Marc Andreessen and Ben Horowitz are hosting a new live show called "One on One with A and Z", where they go deep on questions submitted via Twitter. The show is based in part by a newspaper column that Andy Grove did in the 80s, where readers sent in questions for him to answer in his column. In this mega-episode of the a16z Podcast, we've combined their first two episodes into almost three hours of discussion and debate about some of the most important topics in entrepreneurship, tech, and culture. Each of these episodes also initially aired on our new show, a16z Live, which captures and share many of the live discussions and events featuring, hosted, or co-hosted by a16z partners (with outside voices too) on Clubhouse and beyond.

When you hear stories about Amazon's "invention machine" -- which led to a company with not just one or two products but several successful diverse lines of business -- we often hear about things like: Memos, six pages exactly and no powerpoints at all!; or, the idea of just "work backwards from the press release"; and other such "best practices"... But what's often lost in hearing about these is the context and the details behind them -- the what, the how (as well as their origin stories) -- not to mention how they all fit together. Knowing this can give us insight into  how all companies and leaders, not just Amazon and Bezos, can define their cultures and ways especially as they scale. After all, Amazon was once a small startup, too.So in this a16z Podcast with Sonal Chokshi -- the very first podcast for the new book Working Backwards: Insights, Stories, and Secrets from Inside Amazon (out February 9) -- authors Colin Bryar and Bill Carr share not only how Amazon did it, but how other companies can do it, too, drawing on their combined 27 years of firsthand observations and experiences from being in "the room" where it happens. Bill was vice president of digital media, founded and led Amazon Music, Amazon Video, Amazon Studios; and Colin started out in the software group, was a technical vice president, and then, notably, was one of Jeff Bezos' earliest shadows -- the shadow before him was in fact Andy Jassy, president and CEO of Amazon Web Services (soon to be CEO of Amazon).The two share not only the early inside stories behind (ultimately) big business moves like AWS, Kindle, Prime -- but more importantly, the leadership principles, decision making practices, AND operational processes that got them there. Because "working backwards" is much, much more than being obsessed with your customers, or having company values like "are right a lot”, "insist on the highest standards", "think big", "bias for action", and more. The discussion also touches on hot-topic debates like to lean-MVP-or-not-to-be; the internal API economy; do you even need a chief product officer; and if you need less, not more, coordination as you grow. Can startups really be like Amazon? Yes: and it comes down to how leaders, organizations, and people at all levels decide, build, invent... using the power of narratives and more.---The views expressed here are those of the AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

In this special “3x”-long episode of our (otherwise shortform) news analysis show 16 Minutes -- past such 2-3X explainer episodes have covered section 230, Tiktok, GPT-3, the opioid crisis, more -- we cover the SolarWinds hack, one of the largest (if not the largest!) publicly known hacks of all time... and the ripple effects are only now starting to be revealed. Just this week, the U.S. Cybersecurity and Infrastructure Security Agency shared (as reported in the Wall Street Journal) that approximately 30% of both private-sector and government victims linked to the hack had no direct connection to SolarWinds. So who was compromised, do they even know, can they even know?!Because this hack is a supply-chain compromise involving various third-party software and services all connected together in a "chain of chains", the knock-on effects of it will be revealed (or not!) for years to come. So what do companies -- whether large enterprise, mid-sized startup, or small business -- do? What actually happened, and when does the timeline really begin? While first publicly revealed in December 2020 -- we first covered the news in episode #49 here when it first broke, and there have been countless headlines since (about early known government agency victims, company investigations, other tool investigations, debates over who and how and so on) -- the hack actually began not just a few months but years earlier, involving early tests, legit domains, and a very long game.We help cut through the headline fatigue of it all, tease apart what's hype/ what's real, and do an "anatomy of a hack" step-by-step teardown -- the who, what, where, when, how; from the chess moves to technical details -- in an in-depth yet accessible way with Sonal Chokshi in conversation with a16z expert and former CSO Joel de la Garza and outside expert Steven Adair, founder and president of Volexity. The information security firm (which specializes in incident response, digital forensics/ memory analysis, network monitoring, and more) not only posted guidance for responding to such attacks, but also an analysis based on working three separate incidents involving the SolarWinds hackers. But how did they know it was the same group? And why was it not quite the perfect crime?image: Heliophysics Systems Observatory spacecraft characterize, in the highest cadence, the constant stream of particles exploding from the sun affect Earth, the planets, and beyond via NASA Goddard Space Flight Center / Flickr

In recent years, there’s been a shift in how we think about psychedelics – from drugs of abuse and recreation, to powerful drugs for treating neuropsychiatric conditions such as depression, addiction, and PTSD.  But there’s still a lot we don't know about how they work, and how we can maximize their therapeutic benefits while minimizing their adverse side effects. So this episode of Journal Club discusses a method for striking that balance, from a paper published in Nature last month, “A non-hallucinogenic psychedelic analogue with therapeutic potential“... which could represent a major step forward in psychedelic medicine. This episode first appeared on Bio Eats World:https://a16z.com/2021/01/21/journal-club-safer-psychedelic/

The rise of developers -- as buyers, as influencers, as a creative class -- is a direct result of "software eating the world", and of key shifts in IT from on-prem to cloud & SaaS to the API economy, where application programming interfaces are essentially building blocks for innovation. Developers therefore not only play an outsized role in high-performing tech companies -- but managing and motivating them is actually critical in ALL companies, since every company is a tech company (whether they know it or not).As every industry turns digital, and a company's interface to their customers IS software, "asking" one's developer is the key to solving business problems and to thriving not just surviving, argues Jeff Lawson, CEO and co-founder of cloud communications platform-as-a-service company Twilio, in his new book, Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century. So in this episode of the a16z Podcast in conversation with Sonal Chokshi and David Ulevitch (who previously argued "the developer's way" is the future of work), Lawson shares hard-earned lessons learned, mindsets, strategies, and tactics -- from "build vs. buy" to "build vs. die", to the art and science of small teams ("mitosis") -- for leaders and companies of all sizes.But what does it mean to truly treat developers as creatives within an organization? What does it mean to be "developer first"? And how does this affect customers, product, go-to-market? All this and more in this episode.

All about section 230 of the Communications Decency Act -- in what Wired senior writer (and host of the Get Wired podcast) described as "one of the clearest-but-still-nuanced explainers I've heard - worth listening to". So what does and doesn't it say? How does this law play out against broader questions and debates around platforms, content moderation, and free speech? This conversation between Mike Masnick (founder and editor in chief of Techdirt) and a16z editor in chief Sonal Chokshi was originally published on our show 16 Minutes, in the context of previous protests and presidential tweets (and an executive order then to prevent “online censorship”)-- but is exactly as relevant today... perhaps now more than ever.https://a16z.com/2020/05/31/16mins-section-230-communications-decency-act-content-moderation-free-speech-internet-past-present-future/image: presidential tweet activity/ Wikimedia Commons

If software’s eating the world -- and more specifically, bringing costs down and increasing productivity through entire industries -- why have some industries, like healthcare, been so resistant? And what could the future look like once technology really gets in? With a16z co-founder -- and author of the now nearly decade-old thesis of “software eating the world” -- Marc Andreessen, in conversation with a16z bio general partner Vijay Pande. This episode originally ran on our show Bio Eats World, but we’re sharing it here in the new year as it’s very relevant for ANYone interested in, well, the future of software eating the world;)  https://a16z.com/2020/12/14/cost-disease-healthcare-baumol/

"In a year that left us speechless, 2020 has been filled with new words unlike any other”... so it's unprecedented that for the first time, the Oxford English Dictionary did NOT name a word of the year. But do we really need the dictionaries to tell us what our words of the year are? Especially if the approaches "Big Word" takes may be based on more lagging vs. leading indicators; after all, language is created and constructed as we go.And yet. People want the dictionary to give them permission of "tell me what the words are", observes internet linguist (and author of the NYT bestselling book Because Internet: Understanding the New Rules of Language) Gretchen McCulloch. No! We, the people, decide what the words are!! So in this special holiday, end-of-year episode, a16z Podcast showrunner Sonal Chokshi chats with McCulloch about the words of the year in and beyond Oxford's "Words of an Unprecedented Year" report -- and importantly, the tech shifts and cultural shifts behind them.From remote work portmanteaus to scientific discourse in a pandemic (for better and for worse) to social movements and more -- we take a whirlwind tour through the words of the year, exploring misplaced analogies, shifting metaphors, and even the evolution of interfaces. We dip into the settling of the "Zoomer" generation and "moonshots"; dive into the need for "third places" and parties; debate Dunbar numbers for conversations, and the trend of "proximity chat" -- and discuss the meta story of language, and of writing itself. The English language may have resulted from network effects involving the "loners" who introduce words, and the “leaders” who spread them; but writing is a technology that spreads with the tools, going well beyond medium/message, connecting us across time and place and online spaces. image: Andy Simmons / Flickr

In this special episode of Bio Eats World -- which aired right after the FDA authorized Moderna's mRNA vaccine for emergency use -- Moderna CEO Stephane Bancel tells the story of not just the vaccine’s development, but the machine that made the vaccine: the platform, the technology, and the moves behind the vaccine’s development.How does this new technology that uses mRNA work; why is this such a fundamental shift in the world of drug development; and where will this technology go next? https://a16z.com/2020/12/18/moderna-covid-vaccine-mrna-technology/

This episode features two relevant but previously recorded episodes, discussing the relevance of the Paycheck Protection Program (or PPP) from the Small Business Administration and the role of government stimulus/ pandemic relief for the economy as well as where tech comes in. It combines 2 separate episodes, beginning with one recorded much earlier this year (on our show 16 Minutes), which outlines a useful analogy of "eminent domain" for government-mandated shutdowns of certain businesses and technology considerations; and then is followed by an episode (recorded later this year) on preventing fraud and the role of fintech. Both episodes feature in common a16z general partner in fintech Alex Rampell, who also wrote about how Small Businesses Depend on the Stimulus Package, and The Stimulus Will Depend on Fintech, which you can find at: a16z.com/pandemicstimulus

The intersection of social and finance—as well as shifting attitudes around what we share about money online—have given way to an ambitious new wave of financial products.While revealing one’s financial information was once considered taboo, now people are more apt than ever to openly discuss money online, particularly Gen Z and millennials. That’s evident on both ends of the spectrum, whether people are bemoaning their crushing levels of student debt on Twitter and Instagram or bragging about their latest stock trades on WallStreetBets. The repercussions extend far beyond social media, fueling a wave of new social-fintech products like Public, Commonstock, and Doji, among others.In this conversation between fintech partner Anish Acharya, formerly a product manager at Credit Karma, consumer partner D’Arcy Coolican (who himself is a former founder in this space), and host Lauren Murrow, we discuss why the “holy grail” of social plus finance is both so challenging and, potentially, so rewarding. This episode was originally released last year and has been resurfaced as part of Social Strikes Back, a new series exploring the next generation of social networks and how they’re shaping the future of consumer tech. See more at a16z.com/social-strikes-back.

There's a few ontologies for describing the phases leaders -- and their startups -- go through, whether it's product-sales-etc. or pioneer to settler. In any case, as companies evolve, so must the leaders -- but can the same person transition across all these phases? When and when not; what are the qualities, criteria, and tradeoffs to be made?In this episode of the a16z Podcast, originally recorded as an internal hallway-style chat (pre pandemic!) a16z general partner Martin Casado, who co-founded but decided to remain CTO of Nicira -- and previously shared his own journey, lessons learned, and advice for founders about bringing in an external CEO and the question of "to CTO or not to CTO" -- and Armon Dadgar, co-founder (with Mitchell Hashimoto) and CTO of HashiCorp, chat with Sonal Chokshi about both managing their past psychology through these common questions and decisions. They also share their strategies on managing the specific tactics behind it all: Everything from the "dating" process of finding an external CEO to figuring out swim lanes; handling debates and decisions; who presents, who sells. And while the conversation is a brief glimpse into their longer personal journeys, there's lessons in it for startups and leaders of all kinds on the art of hiring and sales, managing credit and conflict, and more...

What happens if we treat food as a medicine in the healthcare system: How, where, and who (pays)? What role can technology play in increasing access, distribution, and more? General partner Julie Yoo talks with the founder and former medical director of Geisinger Fresh Food Farmacy, Dr. Andrea Feinberg, and with the co-founder of food delivery start up Plated in this "holiday" cross-promo of our show Bio Eats World.

This episode features Q&As with two artists who are exploring crypto-powered auction sites and marketplaces – this is part of our ongoing series on the creator economy. The big picture is that emerging "tokenization" models, especially non-fungible tokens, or NFTs, are creating new ways for collectors and investors to buy, sell, and trade digital art. More broadly, these innovations open the door to the tokenization of any products or collectibles that can be captured and owned digitally.  Marketplaces powered by NFTs open up new revenue streams for creators, because anytime digital work is resold or their tokens traded on these platforms, no matter how many times, the creator gets a percentage of those secondary sales. It's all transparent and governed by code on the blockchain, and it’s a big shift in creator economies. Our first guest is one of the biggest names in crypto art, and one of the most mysterious. Murat Pak is the artist and industrial designer who created the AI-powered image sharing site Archillect. Pak has made it a policy to separate their personal identity from their online work, and prefers to keep their quote-unquote real identity hidden, so we conducted this interview by email and converted Pak’s answers to audio using text-to-speech software. As Pak has expressed in other interviews, it's really the work that matters. And we do know a lot about the work, Pak has sold more than 60 pieces of digital art this year on the auction site SuperRare, for more than $350,000. And that’s just one of the several platforms on which Pak’s work is sold.  In this Q&A, Pak talks with a16z's Zoran Basich about NFTs. These "non-fungible tokens" are unique assets that are not interchangeable. Dollar bills are fungible — each dollar bill is worth exactly the same as every other one. But works of art, for example, or any collectible, can be non-fungible — their value varies based on the market for that particular asset. With crypto, these assets carry digital ownership rights that can be easily exchanged. We start by discussing the whole concept of digital art, and why anyone would pay for something that (seemingly) can be easily copied. Our second interview is with Signe Pierce, a visual, digital, and performance artist whose work has appeared in major galleries in Paris, Los Angeles, and New York. She’s currently featuring her artwork on the creator marketplace Foundation. On that site, in addition to auction-style NFT markets, the price of tokens associated with individual works of art is something like you’d see on a stock market – the pricing is real-time, and dynamic and fluctuates according to demand by buyers, who might be investors, collectors, or fans. Signe discusses why she went from working exclusively with galleries to trying crypto marketplaces, how this move affects her work and her business, and how crypto could change the way she engages with her fans. She also offers advice for creators interested in getting into the world of crypto. She starts off by talking about how social media popularity several years ago opened her eyes to the idea of new monetization models for creators.

A vaccine for COVID seems to be (almost) here… or is it? What’s hype/ what’s real beyond the headlines (and beyond the press release), when it comes to the announcement last week from Pfizer and BioNTech that their vaccine candidate was found to be more than 90% effective in preventing COVID-19 -- and relatedly, the most recent news around Moderna's vaccine candidate? Of course, this was just the first interim efficacy analysis — so how close or far are we? What’s the significance of the readout and case numbers? How do we put all this in context of all the other (458!) programs in development? And how much should/ shouldn’t we read into the news, given the buzzy excitement and penchant for evaluating "science via press release"? a16z bio general partners Vineeta Agarwala and Jorge Conde recently broke it all down in conversation with Sonal Chokshi on our show 16 Minutes: the math, the science, and the practical considerations — from “vaccine efficacy” vs. efficiency, from cold chains to distribution, from patients to the system… as well as why mRNA matters in the present future of vaccines.

True cloud-native games—those exclusive to and solely playable within the cloud—are poised to revolutionize gameplay and unlock new avenues of hyper-personalized storytelling and socializing. It's a vision that, though steadily advancing, is still in its early stages. Just one year ago this week, Google launched its cloud gaming service, Stadia, which shares the space with competitors including Microsoft's xCloud, Playstation Now, and Nvidia’s GeForce. In this episode, Jade Raymond, VP of Stadia Games and Entertainment, Jonathan Lai, formerly of Riot Games and Tencent, and host Lauren Murrow talk about the challenges in building cloud-native games, their potential to upend prevailing business models and pricing, and, most importantly, the spontaneous, social, super-shareable experiences that true cloud streaming  will reveal. Through the rise of user-generated content, AI, and the cloud, they believe we're inching ever closer to the Metaverse.This episode is part of Social Strikes Back, a new series exploring the next generation of social networks and how they’re shaping the future of consumer tech. See more at a16z.com/social-strikes-back.

Lakes v. warehouses, analytics v. AI/ML, SQL v. everything else... As the technical capabilities of data lakes and data warehouses converge, are the separate tools and teams that run AI/ML and analytics converging as well?In this podcast, originally recorded as part of Fivetran's Modern Data Stack conference, five leaders in data infrastructure debate that question: a16z general partner and pioneer of software defined networking Martin Casado, former CEO of Snowflake Bob Muglia; Michelle Ufford, founder and CEO of Noteable; Tristan Handy, founder of Fishtown Analytics and leader of the open source project dbt; and Fivetran founder George Fraser.The conversation covers the future of data lakes, the new use cases for the modern data stack, data mesh and whether decentralization of teams and tools is the future, and how low we actually need to go with latency. And while the topic of debate is the modern data stack, the themes and differing perspectives strike at the heart of an even bigger: how does technology evolve in complex enterprise environments?

How to moderate good, productive discussions and navigate tricky conversations is top of mind -- whether doing a panel, conducting a live event, presenting a talk (or hosting a podcast), managing (and even just participating in!) a meeting. Especially in a world where remote and virtual work is increasingly become the norm for many knowledge workers, one in which we're increasingly communicating through little "Hollywood Squares, Brady Bunch"-like boxes.So how to translate physical and nonverbal presence in such virtual environments, or voice-only modes? How to manage unruly discussions? Do parasocial vs. social interactions change things? And beyond these broader contexts, how do the things inside us -- whether agendas, tics, anxiety -- manifest outwardly, and can we better control them?In this episode of the a16z Podcast, Matt Abrahams -- lecturer at Stanford’s Graduate School of Business (where he also has a podcast, "Think Fast Talk Smart"); principal and co-founder of Bold Echo (a company that helps people with presentation and communication skills); and author of Speaking Up Without Freaking Out -- shares frameworks and best practices, in conversation with Sonal Chokshi. The discussion offers many concrete tips for moderation and communication for anyone, across all kinds of mediums and modes. image: Paul Hudson / Flickr

"The most profound technologies are those that disappear. They weave themselves into the fabric of everyday life until they're indistinguishable from it." That quote from computer scientist Mark Weiser is from a 1991 paper where he outlined the vision of ubiquitous computing; in it, he also referenced "seamlessness"... We just can't get away from textile metaphors: we catch airline "shuttles", we "weave" through traffic, we follow comment "threads” -- the metaphors are as ubiquitous and abundant and threaded throughout our lives as the textiles (and computing) all around us.In fact, argues author and columnist Virginia Postrel, the story of textiles IS the story of technology and science (across all kinds of fields, from biology to chemistry); of commerce (as well as management, measurement, machines); but most of all, of civilization (vs. just culture) itself. That's what her new book, The Fabric of Civilization: How Textiles Made the World is all about. But it's really a story and history of innovation, and of human ingenuity... which is also the theme of the a16z Podcast -- and of this special, inaugural book launch episode with the author in conversation with showrunner Sonal Chokshi.The discussion both dives deep and lightly dips into a wide range of topics: fabrics, from the genetics of cotton to the supply chain of silk (including pre-Industrial Revolution factories, early payment and incentive alignment, "maestre" and notions of expertise); knowledge, from the storage and transmission of it to sharing tacit and explicit code (including manuals, notation, measures); and math as the science of patterns, origins of mathematics (including early education and getting paid for it). The touch on the NASA space program, knitting and AI, and the environmental impact of dyes. Throughout, they discuss the what and the why -- the warp and weft of this episode! -- of HOW innovation happens, from incremental improvements to sudden leaps, also taking a closer look at the demographics and images involved. And finally, they cover the evolution and meaning of kente cloth (as well as other patterns) in Ghana and beyond... Because the story of textiles -- and of technology -- is not just a story of one culture or time or place: it is a universally human story, woven from countless threads and wires.links & other articles mentioned in this episode:YouTube & Instagram from the author, featuring cited images among othersThe Computer for the 21st Century, Mark Weiser, Scientific American, 1991Every topological surface can be knit: a proof, Sarah-Marie Belcastro, Journal of Mathematics and the Arts, 2009How an AI took over the an adult knitting community, Alexis Madrigal, The Atlantic, 2018Portrait of a Man, Portrait of a Woman, Maarten van Heemskerck, Rijks Museum, 1529In Ghana, pandemic inspires new fabrics, Kent Mensah, Christian Science Monitor 2020Welcome to the new world civilization, Virginia Postrel, Reason, 2020images: composite of knitting by © sarah-marie belcastro (courtesy Virginia Postrel) + magnetic core memory wires & beads, magnified 60x (photo from Virginia Postrel) -- combined by Sonal Chokshi for the a16z Podcast

Data, data, data – it’s long been a buzzword in the industry, whether big data, streaming data, data analytics, data science, even AI & machine learning — but data alone is not enough: it takes an entire system of tools and technology to extract value from data. A multibillion dollar industry has emerged around data tools and technologies. And with so much excitement and innovation in the space: how exactly do all these tools fit together? This podcast – a hallway style conversation between Ali Ghodsi, CEO and Founder of Databricks, and a16z general partner Martin Casado – explores the evolution of data architectures, including some quick history, where they’re going, and a surprising use case for streaming data, as well as Ali’s take on how he’d architect the picks and shovels that handle data end-to-end today.

Gen Z—those born between 1995 and 2010—now makes up 35 percent of the population and represent $143 billion dollars in spending power. This episode is all about how brands can better understand, collaborate with, and resonate with this hugely influential segment of consumers. Our guest, Tiffany Zhong, is the 24-year-old CEO of Zebra IQ, a company that helps brands interpret the wants of Gen Z consumers and helps Gen Z creators turn their content into businesses. In its recent Gen Z Trends Report, her company highlights important cultural trends and Gen Z behaviors based on a trove of proprietary research. In this conversation, Tiffany and a16z general partner Connie Chan discuss the key differences between Gen Z and millennials, the growing power of short-form video on platforms like TikTok and YouTube, our changing perception of luxury, and how Gen Z is shifting the paradigm around money, education, and work.The pair breaks down how brands can partner with Gen Z influencers in a way that’s compelling, not cringeworthy, and why when it comes to memes and the art of emoji, you’re probably doing it wrong.

We've already talked a lot about podcasting, both evolution of the industry as well as the form, but where are we going with the future of audio, more broadly? Can we borrow from the present and future of video (e.g., TikTok) to see what's next in audio (more layers, more interactivity)? Can we borrow from the past of audio (i.e., radio) to see what's next for audio experiences (more blending of music, talk, podcasting)? Where do all these mediums converge and where do they diverge -- when it comes to user experience, product design, recommendations, discovery?Gustav Söderström, chief R&D officer (who oversees the product, design, data, and engineering teams) at Spotify -- the world's most popular audio streaming subscription service -- joins this episode of the a16z Podcast for a deep dive on all things audio with a16z general partner Connie Chan and editor in chief Sonal Chokshi. They cover the past, present, and future of audio -- going high level into the big trends and also dipping down into the trenches -- especially given the increased blending of talk/ podcasting, music, more. What are the challenges to designing for different mediums, on both front end and back end (including machine learning and different graphs), when listeners want everything in one place when and where they want it... yet their contexts shift?But the conversation more broadly is really more about what happens when we give creators (of all kinds!) tools -- not just for expression but for fan engagement and monetization too. We also discuss the themes of super apps and full-stack approaches when it comes to innovating on top of a protocol, as well as how innovation happens in practice: How do mediums -- and organizations -- evolve, prioritize, "disrupt themselves"? All this and more in this episode.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

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It seems like investors are especially obsessed with the psychology of decision making -- high stakes, after all -- but all kinds of decisions, whether in life or business -- like dating, product management, what to eat or watch on Netflix -- are an "investment portfolio" of decisions... even if you sometimes feel like you're making one big decision at a time (like, say, marriage or what product to develop next or who to hire).Obviously, not all decisions are equal; in fact, sometimes we don't even have to spend any time deciding. So how do we know which decisions to apply a robust decision process too, which ones not to? What are the strategies, mindsets, tools to help us decide? How can we operationalize a good decision process and decision hygiene into our teams and organizations? After all, we're tribal creatures -- our opinions are infectious (for better and for worse) -- so how do we convey vs. convince, and not necessarily agree but inform to decide? Especially given common pitfalls (resulting, hindsight bias, etc.), and "the paradox of experience", including even (and more so) winning vs. losing.Decision expert (and leading poker player) Annie Duke comes back on the a16z Podcast -- after our first conversation with her for Thinking in Bets, which focused mainly on WHY our decision making gets so frustrated -- to talk about her new book, which picks up where the last left off, on HOW to Decide: Simple Tools for Better Choices. In conversation with a16z managing partner Jeff Jordan (and former CEO of OpenTable and former GM of eBay among other things) -- so, from all sides of investing, operating, life -- Annie shares tips for decision makers of all kinds making decisions under uncertainty... really, all of us. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Millennials and Gen Z have been hard-hit by the one-two punch of the 2008 and 2020 financial crises. That experience has radically shaped their approach to finances and their mindset around credit and debt. This episode explores how fintech founders are now designing products tailored to the financial challenges of younger consumers, from managing and avoiding student loans to building credit to saving and budgeting apps. Historically, students have largely been overlooked by traditional banks. Due to a combination of economic forces, predatory lending practices, and uninformed decisions, millennials have more outstanding student loans—and owe more money—than any prior generation. According to a poll conducted this month by the data intelligence company Morning Consult, just 46 percent of millennials believe their student debt was worth attending college. Amira Yahyaoui wants to change that. She’s the founder and CEO of Mos, a platform that allows students to apply for every government college financial aid program with a single application. In this episode, Amira joins host Lauren Murrow and a16z fintech partners Anish Acharya and Seema Amble to discuss how fintech can cut through bureaucracy, downsize student debt, and optimize—and ultimately automate—consumers’ financial futures from an early age.

Welcome to the second episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine.Many diseases are caused by proteins that have gone haywire in some fashion. There could be too much of the protein, it could be mutated, or it could be present in the wrong place or time. So how do you get rid of these problematic proteins? In this episode of Journal Club (now on Bio Eats World), Stanford professor Carolyn Bertozzi and host Lauren Richardson discuss the article “Lysosome-targeting chimaeras for degradation of extracellular proteins” by Steven Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn, Nicholas Riley, and Carolyn Bertozzi, published in Nature (2020).Dr. Bertozzi and  her lab developed a class of drugs — or modality — that tosses the disease-related proteins into the cellular trash can. While there are other drugs that work through targeted protein degradation, these drugs called LYTACs are able to attack a set of critical proteins, some of which have never been touched by any kind of drug before. The conversation covers how they engineered these new drugs, their benefits, and how they can be further optimized and specialized in the future.

Welcome to the first episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine.In this episode, we talk all about the science of aging. Once a fringe field, aging research is now entering a new phase with the first clinical trials of aging-related drugs. As the entire field shifts into this moment of translation, what have we learned? What are the basic approaches to developing aging-related drugs? How is studying aging helping us understand diseases like cancer and Alzheimer’s -- and increasing the amount of time we are healthy -- today? In this conversation, Laura Deming, founder of The Longevity Fund; Kristen Fortney, co-founder of BioAge, a clinical-stage company focused on finding drugs to extend healthspan; Vijay Pande, general partner at a16z; and host Hanne Winarsky discuss the entire arc of aging science from one genetic tweak in a tiny worm to changing a whole paradigm of healthcare delivery.Be sure to subscribe to 'Bio Eats World' if you want to keep getting it (and please feel free to rate it as well). To learn more about the expanding a16z Podcast network, please visit a16z.com/podnetwork.

With the U.S. tech partnership for TikTok being finalized, what happens if source code is excluded (and more specifically, the For You Page algorithm), given China’s revised export controls? But more broadly -- well beyond the specifics and politics of this deal -- what does the success of TikTok tell us about “creativity network effects”, where every additional creator makes the rest of the community more creative? How did "seeing like an algorithm" and the new age of algorithm-friendly product design enable the short video-sharing platform to grab massive marketshare in cultures and markets never experienced firsthand by the engineers and designers in China, beating out other dominant players and apps in the United States?In this episode of 16 Minutes -- our show where we discuss what's in the news, tease apart what's hype/ what's real, and  where we are on the long arc of innovation  with specific tech trends with top experts -- Eugene Wei (former head of product at Hulu, Flipboard, and video at Oculus) joins us. We also touch on the future of entertainment, education, and the power and future of video.full transcript here: https://a16z.com/2020/09/18/16mins-tiktok-seeing-like-an-algorithm-friendly-design-creativity-network-effects-video/---This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Today’s episode, part two in our two-part series on the Creator Economy, focuses on the new potential revenue streams and fan-engagement models opened up by emerging decentralized technology. It's a new type of fan club, driven by crypto networks and aiming to give creators more power in the commercial sphere. Zoran Basich of a16z talked to two guests deeply immersed in these topics. Kayvon Tehranian is the founder and CEO of Foundation Labs, a platform for buying and selling limited edition goods. Think of it as a crypto marketplace that creates new revenue streams for creators, and financial incentives for buyers. Before that he was head of product at cryptocurrencies marketplace Dharma Labs, and he has long worked on making crypto more accessible to the mainstream. Jesse Walden is a former a16z partner who recently launched his own fund, Variant, which focuses on what he calls the ownership economy enabled by crypto. He also previously cofounded the startup Mediachain, which was acquired by Spotify, and is a former music promoter and manager whose focus was on helping artists stay independent. Kayvon and Jesse explain how the emerging crypto models differ from previous attempts to create new revenue streams for artists, and about the role of speculation and hype in creator markets. They also debate whether these new markets will largely be driven by financial motives, or whether cultural factors will be equally powerful in determining the growth of creator markets. And they offer advice to creators interested in exploring this new world, including important practical guidance on expectations and timelines.

This episode, part one in a two-part series on the Creator Economy, explores the process and economics behind creating an independent newsletter. In this candid conversation, host Lauren Murrow talks with four Substack writers—an artist, a technologist, a journalist, and a clinical researcher-turned-psychedelics scholar—about how to find and foster an audience, the calculus behind going paid versus unpaid, the pressure to produce, and financial benchmarks for making a living from newsletter writing.The pandemic has prompted a reckoning within traditional media  and, in parallel, a surge in the newsletter ecosystem. On Substack, readership and active writers both doubled from January through April. The newsletter hosting platform now has more than 100,000 paying subscribers.This episode reveals the behind-the-scenes experiences of four newsletter creators, all of whom launched roughly within the past year:Software engineer Lenny Rachitsky, most recently a growth product manager at Airbnb, whose tech-focused dispatch is called Lenny’s Newsletter.Artist and writer Edith Zimmerman, creator of the Drawing Links newsletter, which chronicles her life and musings through comic-style illustrations. Zach Haigney, an acupuncturist and researcher whose newsletter, The Trip Report, explores the science, policy, and business behind medicinal psychedelics.And Patrice Peck, a freelance journalist—previously a staff writer at BuzzFeed—whose newsletter, Coronavirus News for Black Folks, highlights the pandemic’s disproportionate impact on the black community.Listen to the end of the episode to hear more about Patrice, Zach, Edith, and Lenny's top newsletter recommendations:Patrice’s newsletter recs:The Intersection by Adriana LacyBeauty IRL by Darian Symone HarvinCarefree Black Girl by Zeba BlayMaybe Baby by Haley Nahman Zach’s newsletter recs:Stratechery by Ben ThompsonSinocism by Bill BishopA Media Operator by Jacob Cohen DonnellyOff the Chain by Anthony PomplianoThe Weekly Dish by Andrew Sullivan Edith’s newsletter recs:The Browser by Robert CottrellThe Ruffian by Ian LeslieRidgeline by Craig ModDearest by Monica McLaughlinWhy Is This Interesting? by Noah Brier and Colin Nagy Lenny’s newsletter recs:2PM by Webb Smith Li’s Newsletter by Li Jin Alex Danco’s Newsletter by Alex DancoTurner’s Blog by Turner NovakNext Big Thing by Nikhil Basu Trivedi Big Technology by Alex KantrowitzThe Profile by Polina MarinovaEverything by Nathan Baschez, Dan Shipper, Tiago Forte, and Adam KeeslingNot Boring by Packy McCormick  Illustration: Edith Zimmerman

Since Netflix started in the late 90s as a DVD-by-mail rental service competing with Blockbuster, it has completely reinvented itself... twice – first, when it went from DVD rental to video streaming platform, and then again when it went from licensing to producing original content.But what does it take to create an organization capable of reinventing itself?In this episode, originally recorded for the Commonwealth Club of California, Netflix CEO and co-founder Reed Hasting talks about his new book "No Rules Rules: Netflix and the Culture of Reinvention" with a16z co-founder and fellow author Ben Horowitz, who also wrote a bestselling book about culture last year. During the conversation, Reed tells the story of Netflix's evolution and his management philosophy, including the hard lesson he learned about what happens when you optimize for efficiency at the expense of creative talent. He also explains why sometimes a more narrow market focus is better for growth and shares the tactics that have helped Netflix expand globally and translate a culture of innovation across different countries, from Japan to Brazil to America.

"I'm in a movie, but it's the wrong movie."For better or for worse, we tell the story of entrepreneurs as one of the mythical hero's journey: that's there's a call, a test (multiple tests!), a destination... But nothing truly follows such a clean, linear, storytelling arc. Stories of success and resilience are messy and full of "sleepless nights, anxiety-ridden fears, moments of real despair and failure", observes Guy Raz -- who is the host, co-creator, and editorial director of three NPR programs, including the popular podcast "How I Built This" -- and has a new book (coming out this week) on How I Built This: The Unexpected Paths to Success from the World's Most Inspiring Entrepreneurs.But in sharing these stories, are we also indulging in "failure porn"? Where do (and don't) debates about optimism vs. pessimism come in; does this really squelch the appetite for building? What happens when "unexpected paths" are actually things like a once-in-a-lifetime pandemic? Editor in chief (and showrunner of the a16z podcasts) Sonal Chokshi probes Raz on these questions and more, while also pulling the threads of how storytelling IS business -- whether it's a company or a community or a product or a movement. So what's the difference between "building buzz" and "engineering word of mouth"? And how do the stories we tell ourselves, and others, actually move things?Raz is also an entrepreneur with his own production company; has won numerous awards and accolades; co-created a podcast for kids (Wow In The World); and is hosting a music interview show for Spotify, not to mention his NPR shows. So what's his best interview tip? And how does his story also thread into this broader sea of stories, along with the story of the podcasting industry, and even the story (and history) of the Bay Area? This episode is for anyone wanting to figure out how to rewrite their own story... it's really for everyone.

Monopoly, oligopoly, cartel. All three of those words can describe the (not so) modern education system today, given the cost structures, economics, and accreditation capture -- in everything from who can and can't start a new university (when was the last time a significant change happened there anyway?!) to where government funding really goes to the student loan and debt crisis.Yet degrees do matter, just not for the reasons we think. So what are the tradeoffs -- when it comes to the "right" school, making money, and assessing skills objectively -- between what's been called "hard" (B.S.) and "soft" (B.A.) degrees? What's the best book on career advice, and what advice does Marc Andreessen -- who went to a public university, worked on a revolutionary project there, and started a company right after -- have for students (and others contemplating change in their careers)... and especially for those considering dropping out, delaying, or skipping college altogether?Andreessen shares his thoughts on the purpose, past and present of education (briefly touching on the impact of the pandemic as well) with Dylan Field, CEO of Figma, which is free for students and educators. The Q&A was recorded in August 2020 and originally appeared as a video in their "Back to School?" interview series; it was actually inspired by the question of taking a gap year and questions about whether or not to go back to school this year that came up in their Virtual Campus community of students from across the world. image: Lyndsy Rommel / Flickr

This episode examines the potential for misuse and fraud among those applying for the Paycheck Protection Program (PPP)—and how fintech and software provide overlooked tools to stop it.  On March 27th, the government enacted a $2.2 trillion dollar stimulus package called the CARES Act, the largest aid measure in history. The act provides more than $500 billion for the Paycheck Protection Program, or PPP, a low-interest, forgivable loan program designed to help small businesses and self-employed individuals retain workers and stay afloat during the pandemic. Since March, the Small Business Administration has approved billions of dollars in PPP loans. But it is also estimated that U.S. losses from coronavirus-related fraud and identity theft have reached almost $100 million. According to the New York Times, the Small Business Administration’s fraud hotline has received 42,000 reports about coronavirus-related cheating and misuse; by comparison, last year it had less than 800.To date, the Department of Justice has charged more than 40 cases of PPP-related schemes, from claiming non-existent employees or non-existent businesses to identity theft, kickback schemes, fake tax documents, and multi-state fraud rings. Most of those cases have alleged fraud of more than a $1 million. But what about the countless others that may be cheating taxpayers out of smaller—but not insignificant—sums? How does the government decide who should get money and who shouldn’t among millions of applications from businesses of all industries and sizes—and what role do banks play? How does the program then distribute that money quickly and accurately—or not, in many cases? And what tools are at our disposal to catch those who cheat the system? Host Lauren Murrow is joined by Bharat Ramamurti, the original member of the COVID-19 Congressional Oversight Commission, which is tasked with evaluating the impact of coronavirus relief loans; Naftali Harris, the CEO of SentiLink, a software company that builds technology to detect synthetic fraud; and a16z fintech general partner Alex Rampell.

Okay, so we know community is important -- whether for developer relations for your product or other types of communities -- but how do we measure the success of community initiatives and even artifacts (like events or schwag), given how indirect and long-cycle so much of it is? How do we know we're even measuring the right things, and is there one key metric or KPI for measuring the health of a community? Where do "meta communities" or where does engaging key community leaders come in?And when it comes to developer relations specifically, where should devrel sit in an organization (product, sales, engineering)? Who should you hire first? How do you reconcile developer as customer vs. developer as community member? And what's the difference between evangelism and advocacy?Amir Shevat -- former VP of Product and Developer Experience at Twitch and former Director of Developer Relations at Slack who also previously worked at Google and Microsoft -- drew on his experiences to share insights and answers to these questions, as well as provides an overview of key concepts, followed by a Q&A with Mikeal Rogers, who works on Community Operations at Protocol Labs, and was formerly Community Manager of the Node.js foundation (and has shared insights on the changing culture and community of open source on a previous episode of the a16z Podcast).This episode is based on a conversation that took place at a portfolio workshop event from a couple years ago organized by former a16z crypto partner Jesse Walden, because crypto gives developers the ability to build on top of and extend any protocol or application in the space, and developer relations and community building is an important part of that being realized. You can find the latest on company building best practices for crypto at a16z Crypto Startup School and see other pieces in our ongoing community series at a16z.com/community.

There is no spoon. Or rather, “There is no such thing as ‘data’, there’s just frozen models”, argues Peter Wang, the co-founder and CEO of Anaconda — who also created the PyData conferences and grew the early data science community there, while on the frontlines of trying to make Python useful for business analytics. He views both models and data as fluid, more like metaphysics than typical data management… Or perhaps it’s that when it comes to data, those with a physics background just better appreciate the mind-bending complexity and challenges of reining in the natural world, and therefore get the unique challenges of AI/ML development, observes a16z general partner Martin Casado — whose first job after college involved computational physics simulation and high-performance computing in Python at Lawrence Livermore National Laboratory. (Wang, meanwhile, graduated in physics.)But this not just a philosophical question — the answer has real implications for the margins, organizational structures, and building of AI/ML businesses. Especially as we’re in a tricky time of transition, where customers don’t even know what they’re asking for, yet are looking for AI/ML help or know it’s the future. So what does this all mean for the software value chain; for open source collaboration and commodification; and for the future of software businesses? After all, it’s not written in stone that “All information systems must be deconstructed into hardware, and software, and data” and that “software must have these margins”… Will there be a new type of company? image: Pawel Loj / Wikimedia Commons

This episode is all about education and technology, a topic that’s especially top of mind this week as students in much of the country return to school—virtually. The intersection of learning and technology has been accelerated by the pandemic, but the debate around education's "disruption," and what that means for educators doing the hands-on work of teaching, has been swirling for years.In this episode, a16z general partner Connie Chan and host Lauren Murrow are joined by educators and experts Josh Kim, the Director of Online Programs and Strategy at  Dartmouth College (whose most recent book, Learning Innovation and the Future of Higher Education, was published earlier this year), and David Deming, Professor of Education and Economics at the Harvard Kennedy School and the Harvard Graduate School of Education.We explore the complicated issue of online education from a variety of angles: Can the quality of online learning stack up to an  in-person education? What improvements have we seen over the past decade and what improvements are we likely to see this fall, compared to the COVID scramble last spring? And might this moment be the push we need for educators and technologists—sometimes at odds—to collaborate more closely?We discuss and debate the research behind online learning, the dual impact of tech and COVID on the future of higher ed, and tech's potential in everything from curriculum to access to structural inequality.

WHEN are we going to have a COVID-19 vaccine, and how the heck are we going from (what’s been traditionally been up to) 12 years or so of vaccine development compressed into 12 months or so? What will and won’t be compromised here, and where do new technologies -- like mRNA or messenger RNA vaccines -- come in? Where will vaccines likely be distributed first, who will and won't get them initially, both across populations... and nations?Rajeev Venkayya, president of the Global Vaccine Business Unit at Takeda Pharmaceutical Company and former White House Special Assistant to the President for Biodefense (where, among other things, he was the principal author of the National Strategy for Pandemic Influenza) joins this special deep-dive episode of the a16z Podcast, in conversation with general partner Jorge Conde to discuss all things vaccines. Including where does manufacturing and scale-up come in -- is "plug and play" really here? -- and by the way, why have we traditionally used eggs in growing vaccines?Where and how can startups and others participate in vaccine development, given how competitive, time-consuming, capital intensive, and risky it is to develop (and sell) them? Can we decouple the question of how we reopen schools with when we have a vaccine? And how do we maintain not just safety and efficacy of vaccines but trust and transparency when it comes to mis/information? We may actually see the emergence of a "Neo Anti-Vaxxer" thanks to the rush... but we may also be entering a renaissance for vaccinology after this pandemic. So what changes, what doesn't? image: Jernej Furman / Flickr

In this episode, we continue our community series with a recent discussion that applies to many kinds of community building. Today’s topic: How do you create a platform that people not only use, but tell their friends about? One that goes beyond just being useful and actually connects deeply with the user? In this discussion, which was recorded at our Crypto Startup School in April 2020, a16z General Partner Chris Dixon talked about building communities — specifically, communities of open-source developers — with GitHub cofounder Tom Preston-Werner. They discussed how to engage early users, how to turn them into your biggest advocates, how to create superfans, and more. Today, GitHub is the leading community for open-source developers and others. They also discuss in-person communities vs. distributed communities, a topic that is very top of mind today.

CAR T therapy is a groundbreaking medicine that uses engineered T cells to attack cancer. But CAR T cells (that is, chimeric antigen receptor T cells) can be programmed to recognize a huge range of target proteins and cell types. So what other types of cells should we train CAR Ts to recognize and destroy to improve human health?On this episode of the a16z Journal Club, a16z General Partner Jorge Conde, bio deal team partner Andy Tran, and Lauren Richardson discuss new research published in Nature in which the authors engineer CAR T cells to recognize and kill senescent cells. Cellular senescence is a process where cells stop dividing (sort of go to sleep), and in many cases this can be protective, like its role in tumor suppression, but if too many cells become senescent of if they are not removed, they can trigger inflammation and cause disease, like in atherosclerosis and type 2 diabetes. Critically, senescent cells build up as we age and contribute to a whole host of age-related conditions. In this episode we cover how the authors created these senescence killing (aka senolytic) CAR T cells, the diseases that could be treated with senolytic CAR Ts, the hurdles to getting them into the clinic, and how they could potentially be used to treat aging and possibly improve longevity.“Senolytic CAR T cells reverse senescence-associated pathologies” in Nature (June 2020) by Corina Amor, Judith Feucht, Josef Leibold, Yu-Jui Ho, Changyu Zhu, Direna Alonso-Curbelo, Jorge Mansilla-Soto, Jacob A. Boyer, Xiang Li, Theodoros Giavridis, Amanda Kulick, Shauna Houlihan, Ellinor Peerschke, Scott L. Friedman, Vladimir Ponomarev, Alessandra Piersigilli, Michel Sadelain & Scott W. Lowea16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology. You can find all these episodes at a16z.com/journalclub.

We're living in an unprecedented era of online collaboration, coordination, and creation. All kinds of people are coming together -- whether in an open source project or company, an R&D initiative, a department in a company, a club or special interest group, even a group of friends and family -- around some shared interest or activity. But the word "members" is faceless, and doesn't help us really understand, support (and better design for) these communities.So in this special book launch episode of the a16z Podcast, Nadia Eghbal -- author of the new book Working in Public: The Making and Maintenance of Open Source Software published by Stripe Press -- shares with a16z editor in chief Sonal Chokshi the latest research and insights from years of studying the health of open source communities (for Ford Foundation), working in developer experience (at GitHub), researching the economics and production of software (at Protocol Labs), and now focusing on writer experience at Substack.Eghbal offers a new taxonomy of communities -- including newer phenomena such as "stadiums" of open source developers, other creators, and really, influencers -- who are performing their work in massive spaces where the work is public (and not necessarily participatory). So what lessons of open source communities do and don't apply to the passion economy and creator communities? How does the evolution of online communities -- really, social networks -- shift the focus to reputation and status as a service? And what if working in public is also about sharing in private, given the "dark forest theory of the internet", the growing desire for more "high-shared context" groups and spaces (including even podcasts and newsletters)? All this and more in this episode.

In this episode -- cross posted from our 16 Minutes show feed -- we cover all the buzz around GPT-3, the pre-trained machine learning model from OpenAI that’s optimized to do a variety of natural-language processing tasks. It’s a commercial product, built on research; so what does this mean for both startups AND incumbents… and the future of “AI as a service”? And given that we’re seeing all kinds of (cherrypicked!) examples of output from OpenAI’s beta API being shared — how do we know how good it really is or isn’t? How do we know the difference between “looks like” a toy and “is” a toy when it comes to new innovations? And where are we, really, in terms of natural language processing and progress towards artificial general intelligence? Is it intelligent, does that matter, and how do we know (if not with a Turing Test)? Finally, what are the broader questions, considerations, and implications for jobs and more? Frank Chen explains what “it” actually is and isn’t and more in conversation with host Sonal Chokshi. The two help tease apart what’s hype/ what’s real here… as is the theme of 16 Minutes.

Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. But when bits and bytes meet flesh and blood, security becomes literally a life or death concern. So what are the issues and risks we need to be aware of in exposing security vulnerabilities in connected biomedical devices?This conversation—with Beau Woods, Cyber Safety Innovation Fellow with the Atlantic Council, part of the I Am The Cavalry grassroots security initiative, Founder/CEO of Stratigos Security; Andy Coravos, co-founder and CEO of Elektra Labs, advisor to the Biohacking Village at DEF CON (both of whom were formerly EIRs at the FDA); and a16z's Hanne Tidnam covers how we should begin to think about addressing these security issues in the biomedical device space. What are the frameworks that should guide our conversations, and how and when (and which!) stakeholders should be incentivized to address these challenges? How did the FDA begin to think about security as part of the safety of all medical devices, including software as a medical device, and how we should think about understanding, monitoring, and updating the security of these devices—from philosophical statements to on-the-ground practical fixes and updates?

Ever since the discovery of antibiotics, microbiologists have worried about and studied how bacteria acquire resistance to these drugs. Adding to the complexity of this problem is the fact that it is not always clear whether the conditions that drive the evolution of resistance in the lab occur in patients suffering from bacterial infections.This is where the work of Nathalie Balaban -- Professor at the Hebrew University, and our guest on this episode -- comes in. The article we discuss is based on a foundation of research done in her laboratory, but this study makes the important step into the clinic by using samples from a patient with a life-threatening bacterial (MRSA) infection. By analyzing these patient samples, Dr. Balaban and her team were able to understand the conditions that lead to multi-drug resistance in a hospital setting. The work reveals how the ability of bacteria to enter a state of dormancy, also known as tolerance, can act as a stepping stone to resistance and can interfere with the efficacy of drug combinations. Our conversation covers what tolerance is, the conditions that promote tolerance, how it can lead to resistance and impact drug combination therapies, and lastly, integrating this new understanding into clinical microbiology protocols."Effect of tolerance on the evolution of antibiotic resistance under drug combinations" in Science (January 2020) by Jiafeng Liu, Orit Gefen, Irine Ronin, Maskit Bar-Meir, Nathalie Q. Balaban.a16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at a16z.com/journalclub.

A dive into the sociological, operational, and tactical realities of this murky underworld, Lusthaus and de la Garza discuss who the players are, what they are motivated by, and specialize in—as well as how basic ideas like trust and anonymity function in a world where no one wants to get caught. How do criminal nicknames function as brand? Which countries tend to specialize in what kinds of crime, and why? And most of all, what changes when you begin to think of the business of cybercrime as an industry?

Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passionate advocate for transparent pricing in the healthcare system. We don’t talk enough (or really at all) about price in healthcare, says Makary (instead, we talk about cost). But shedding a light on prices in healthcare—from not just what those prices are but how prices are set and the value we all receive as consumers of the system overall—can help us measure quality in medicine, and be a driver for real behavioral change in the healthcare system, correcting many of the unintended consequences of a fee-for-service system like surprise billing or unnecessary medical procedures.In this conversation with a16z General Partner Julie Yoo, Makary and Yoo discuss what price transparency in the healthcare system could really do; how we can "steer" towards the good physicians who are not just highly skilled, but make the right judgment calls based on need and holistic health, not cost; how we might distinguish between high value and low value through medical appropriateness; and how we might gain clinical wisdom from other kinds of scientific discovery beyond randomized controls, especially during the wartime protocol of COVID-19.

More than 98% of the information on the web is lost within 20 years, and huge gaps exist in our digital and cultural history. Zoran Basich and Alex Pruden of a16z talk to Brewster Kahle and Sam Williams, who are using different approaches to attack this problem. Brewster cofounded the Internet Archive, which is well known for creating the Wayback Machine that crawls a billion URLs every day. Sam cofounded Arweave, a company that uses decentralized crypto networks to store information forever. For both of them, this issue has implications that go far beyond just data storage. It touches on issues of censorship, government manipulation of information, and how historical context is necessary for well-functioning societies. They discuss how decentralized models offer the promise of building a next-generation web that works better for users.

In part 1 of our series on human performance, we looked at the limits of human potential in climbing and other sports – and how we push those limits through technology and training.In this episode, recorded at our a16z innovation summit last year, Alex talks with a16z general partner and fellow avid climber Peter Levine about the risk, fear, and preparation for his free solo of El Capitan on Yosemite. While climbing is the topic, the conversation holds many lessons for entrepreneurs, and anyone else who is attempting something that’s never been done before – from how to evaluate risk versus reward, moving into the public spotlight from stealth, removing constraints to innovate on established routes, and knowing where you can fall and where you can’t. The conversation finishes with Alex’s life philosophy of living simply and giving back, including how he donates a third of all his income to the Honnold Foundation to support solar projects in underserved communities.

Is there a limit to what humans can do? And if so, how do you know when you've reached it? Welcome to part one of a two-part series on human performance with professional rock climber Alex Honnold. Alex redefined the limits of what is possible by free soloing – that is climbing with no ropes or safety gear – a 2000-foot granite rock face in Yosemite, known as El Capitan. That feat  was documented in the award-winning film Free Solo. In this podcast, Alex, a16z general partner Peter Levine (who at age 59 is still an avid ice climber), and Das Rush discuss how technology and training have pushed the limits of what's possible and how to manage the mental preparation of any big endeavor, whether its building a company, reaching a new peak, or maintaining peak performance while aging.In Part 2, recorded last year as part of our a16z innovation summit, we share a fireside chat with Peter and Alex  about the risk, preparation, and fear around Alex's free solo.  Photo credit: Shawn Corrigan

"Why We Shouldn’t Fear the ‘Black Box’ of AI (in Healthcare and Everywhere)" by Vijay Pande. First published in the New York Times, January 2018. You can also find and share this article at a16z.com/aidoctor

"When One App Rules Them All: The Case of WeChat and Mobile in China" by Connie Chan. First published August 2015. You can also find and share this essay at a16z.com/mobilefirstchina

"Why Every Company Will Be a Fintech Company -- The Next Era of Financial Services and the 'AWS Phase' for Fintech" by Angela Strange.You can also find and share this essay at a16z.com/fintecheverywhere

Today we're continuing a series we started a while ago of read-alouds (for more context on the why and why now check out episode #500 on how we podcast!).The first was episode #544 in April, It's Time to Build, read out loud by Marc Andreessen; what follows are  three more pieces read out loud by their authors:"Why Every Company Will Become a Fintech Company: The Next Era of Financial Services and the 'AWS Phase' for Fintech" by Angela Strange"When One App Rules Them All: The Case of WeChat and Mobile in China" by Connie Chan, first published August 2015"Why We Shouldn’t Fear the ‘Black Box’ of AI (in Healthcare and Everywhere)" by Vijay Pande, first published in the New York Times January 2018

Eroom’s Law is Moore’s Law spelled backwards. It’s a term that was coined in a Nature Reviews Drug Discovery article by researchers at Sanford Bernstein and describes the exponential decrease in biopharma research and development efficiency between the 1950s and 2010. Whereas Moore’s describes technologies becoming exponentially faster and cheaper over time, Eroom’s Law describes the trend of drug development becoming exponentially more expensive over time.The article describing Eroom’s Law was published in 2012, and analyzed data up till 2010. That is perhaps ironic as 2010 appears to be an inflection point in the trend. In Breaking Eroom’s Law, the authors analyze the data since 2010 and show that costs appear to have stabilized over the last ten years. But what has contributed to this critical and exciting trend shift? In our conversation, Jorge and Vijay discuss the three causes cited by the authors of the Breaking Eroom’s Law article, their views on what technologies and policies will continue to push costs down, and their opinion on whether Eroom’s Law is broken for good.

The COVID-19 pandemic has increased the visibility of scientists and the scientific process to the broader public; suddenly, scientists working on virology and infectious disease dynamics have seen their public profiles rapidly expand. One such scientist is the special guest in this episode, Trevor Bedford, Associate Professor at the Fred Hutchinson Cancer Research Center.An expert in genomic epidemiology, he and his collaborators built Nextstrain, which shares real-time, interactive data visualizations to track the spread of viruses through populations.a16z bio deal team partner Judy Savitskaya and Lauren Richardson chat with Trevor about how genomic epidemiology can inform public health decisions; viral mutation and spillover from animals into humans; what can be done now to prevent the next big pandemic; and the shift in scientific communication to pre-prints and open science.

In this episode of the a16z bio journal club, we cover one of the key clinical trials that supported the recent FDA approval of the first prescription video game. The game was developed by Akili Interactive, is called EndeavorRx, and is now a clinically-validated therapy for improving attention in children with Attention Deficit Hyperactivity Disorder (ADHD). But how does a game improve attention? How does a clinical trial evaluate the efficacy of a game? And what are the pros and cons of a video game as compared to traditional pharmacological therapies for ADHD? Bio deal team partner Justin Larkin and Lauren Richardson delve into these questions and more in their discussion of this clinical trial:“A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial” in Lancet Digital Health (April 2020) by Scott H Kollins, Denton J DeLoss, Elena Cañadas, Jacqueline Lutz, Robert L Findling, Richard S E Keefe, Jeffery N Epstein, Andrew J Cutler, and Stephen V Faraone.a16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at a16z.com/journalclub.

Gross margins are essentially a company's revenue from products and services minus the costs to deliver those products and services to customers, and it's one of the most important financial metrics a startup can track.And yet, figuring out what goes into the "cost" for delivering products and services is not as simple as it may sound, particularly for high-growth software businesses that might use emerging business models or be leveraging new technology. Why do gross margins matter? When do they matter during a company's growth? And how do you use them to plan for the future?In this episode, a16z general partners Martin Casado, who invests in early stage enterprise startups and  David George, who leads our growth fund, and Sarah Wang  on the growth investing team share their perspectives on how to think about gross margins in both earlier and later stages at a startup. The conversation ranges from the nuances of and strategy for calculating margins with things like cloud costs, freemium users, or implementation costs to the impact margins can have on valuations.

As more digital natives have entered the workplace, they have brought with them the expectation that their software should both be a joy to use and allow them to be power users. That is, users who configure and control it to better serves their needs. And often, these digital natives aren't just aspiring power users, they are also prosumers, who can and will pay for a premium experience. But first generation SaaS products have often struggled to deliver the experience these users crave.For today's founders and builders, how do you get the user experience right when a product has to delight your power users, while being something a less savvy user can pick up and learn?In this episode, a16z general partner David Ulevitch and Superhuman founder Rahul Vohra discuss how to build products that can turn any user into a power user. The conversation touches on themes from David's recent talk on products that adopt developer tools, like the command palette and keyboard shortcuts, to improve usability, and Rahul's talk on how to apply game design principles to product design. They cover how to onboard users to drive virality, when to expand to a second product, and how to use pricing to position a premium product.

In this episode of the a16z bio Journal Club, bio deal team partner Judy Savitskaya and Lauren Richardson discuss research that aims to enhance the efficiency of photosynthesis and carbon fixation. These two processes are used by plants and other phototrophs (like algae) to convert light energy and carbon dioxide from the air into organic matter. The pathways took millions of years to evolve, but can scientists use advances in biochemistry and synthetic biology to increase their efficiency? The two discussed were both published in the journal Science and are both from the lab of Tobias Erb at the Max Planck Institute for Terrestrial Microbiology. The first article, published in 2016 develops a synthetic pathway for the fixation of carbon dioxide in vitro. The second article, which was published in May, combines this synthetic carbon fixation pathway with the natural photosynthetic pathway isolated from spinach to create an artificial chloroplast.This combination of natural and synthetic components to improve the efficiency of these pathways has a number of potential applications, including in engineering our crops to grow faster. We discuss these exciting applications, how evolution has restricted the efficiency of carbon fixation and how these engineered solutions get around that problem, and the use of microfluidics for vastly improved experimental design. "A synthetic pathway for the fixation of carbon dioxide in vitro" in Science (November 2016), by Thomas Schwander, Lennart Schada von Borzyskowski, Simon Burgener, Niña Socorro Cortina, Tobias J. Erb"Light-powered CO2 fixation in a chloroplast mimic with natural and synthetic parts" in Science (May 2020), by Tarryn E. Miller, Thomas Beneyton, Thomas Schwander, Christoph Diehl, Mathias Girault, Richard McLean, Tanguy Chotel, Peter Claus, Niña Socorro Cortina, Jean-Christophe Baret, Tobias J. Erba16z Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at a16z.com/journalclub.

This episode is the second in a two-part series that examines the pandemic’s impact on real estate. Part 1 focused on prospective home buyers, sellers, and existing homeowners. This episode, Part 2, addresses renters and landlords.The conversation with host Lauren Murrow features a16z general partner Connie Chan, whose experience as a landlord herself has fueled her interest in residential real estate and technology; Richard Green, the director of USC's Lusk Center for Real Estate, and Adena Hefets, the CEO of Divvy Homes, a company that allows people to build up equity while renting a home, with the option to eventually buy it.We begin with the pressures on renters—and the uncertainty around federal relief measures—as well as the cascading effects on mom-and-pop landlords. Then we turn to the outlook for prices and volume in the rental market, particularly in large cities like New York and San Francisco. Finally, we discuss the opportunity for tech to solve outdated and inefficient processes for both renters and landlords.For more a16z content on real estate and proptech, visit a16z.com/realestate.

This episode is the first in a two-part series that examines the pandemic’s impact on real estate. Part 1 focuses on prospective home buyers, sellers, and existing homeowners. Part 2 (streaming on 6/17) addresses renters and landlords.How has social distancing shaken up the market to buy? What’s the ripple effect of eviction freezes and a record number of homes in forbearance? And how can tech streamline the inefficient process of renting, buying, and selling a home?Led by host Lauren Murrow, the conversation features a16z general partner Alex Rampell, who has invested in a number of real estate companies; Malloy Evans, Fannie Mae’s senior vice president and single-family chief credit officer;  and Tushar Garg, CEO of Flyhomes, a company that helps buyers in competitive markets by purchasing their desired house in cash, then selling it to that buyer at the same price.The discussion starts with the impact on home prices and volume, as well as the rumored exodus from densely populated cities. Then we shift to focus on existing homeowners. Finally, we talk about ways tech can improve the system, from hard tech to fintech.For more a16z content on real estate and proptech, visit a16z.com/realestate.

Proteins are molecular machines that must first assemble themselves to function. But how does a protein, which is produced as a linear string of amino acids, assume the complex three-dimensional structure needed to carry out its job? That's where Folding at Home comes in. Folding at Home is a sophisticated computer program that simulates the way atoms push and pull on each other, applied to the problem of protein dynamics, aka "folding". These simulations help researchers understand protein function and to design drugs and antibodies to target them. Folding at Home is currently studying key proteins from the virus that causes COVID-19 to help therapeutic development. Given the extreme complexity of these simulations, they require an astronomical amount of compute power. Folding at Hold solves this problem with a distributed computing framework: it breaks up the calculations in the smaller pieces that can be run on independent computers. Users of Folding at Home - millions of them today - donate the spare compute power on their PCs to help run these simulations. This aggregate compute power represents the largest super computer in the world: currently 2.4 exaFLOPS!Folding at Home was launched 20 years ago this summer in the lab of Vijay Pande at Stanford. In this episode, Vijay (now a general partner at a16z) is joined by his former student and current director of Folding at Home, Greg Bowman, an associate professor at Washington University in St. Louis, and Lauren Richardson. We discuss the origins of the Folding at Home project along with its connection to SETI@Home and Napster; also the scientific and technical advances needed to solve the complex protein folding and distributed computing problems; and importantly what does understanding protein dynamics actually achieve?

The way we deliver healthcare has changed enormously over the last century, shifting from house calls by doctors to your own to institutionalized settings like hospitals and clinics. But now that trend has started to shift again, as some of the care we get in the hospitals and clinics has been "unbundled" back towards home settings for chronically ill patients or seniors. And now, of course, the impact of COVID-19 has created a huge sudden demand for home-based care, as all of us try to figure out how to manage certain healthcare needs at home.So, is home-based healthcare better? And what do we truly need to deliver the best care to patients, in their own homes? What do we gain and lose in different care delivery settings, and what shifts of mindset and new logistical processes do we need now, to best accomplish unbundling healthcare into the home? In this conversation, Vijay Kedar, CEO and cofounder of Tomorrow Health, a tech platform that delivers the products and services needed for home-based care; Sachin Jain, physician, previous CEO of Caremore and Aspire Health; part of the founding team at CMMI, the Centers of Medicare and Medicaid Innovation, now incoming CEO of The Scan Group and Healthplan; and a16z General Partner Julie Yoo join a16z's Hanne Tidnam in conversation to talk about where we are today and where we are going in home-based healthcare.

Primary care was meant to be the front door to the healthcare system, but in some ways never set up for success to begin with. We need a new operating system for primary care—one with a different, deeper understanding of the patient, the context of their world around them, and the processes we have in place to figure out who sees a doctor and when, to use the system most efficiently.In this episode of the a16z Podcast, we talk about what the primary care of the future should actually look like; what kind of data about patients we should be collecting, from where, and to tell us what; how you ask the right questions of that data, to use the resources of our  healthcare system most efficiently and for the best care; and what the PCP of the future might look like. Joining us for the conversation are General Partner Julie Yoo, physician entrepreneur Ivor Horn, a primary care pediatrician for more than 20 years, and Jeff Kaditz, CEO and founder of Q.bio, a platform that identifies and monitors each individual’s biggest health risks.

We cover the tricky but important topic of Section 230 of the Communications Decency Act. The 1996 law has been in the headlines a lot recently, in the context of Twitter, the president’s tweets, and an executive order put out by the White House on “preventing online censorship”. All of this is playing out against the broader, more profound cultural context and events around the death of George Floyd in Minnesota and beyond, and ongoing old-new debates around content moderation on social media. [Please note this episode was first published  May 31.] To make sense of only the technology and policy aspects of Section 230 specifically — and where the First Amendment, content moderation, and more come in — a16z host Sonal Chokshi brings on our first-ever outside guest for 16 Minutes, Mike Masnick, founder of the digital-native policy think tank Copia Institute and editor of the longtime news & analysis site Techdirt.com (which also features an online symposium for experts discussing difficult policy topics). Masnick has written extensively about these topics — not just recently but for years — along with others in media recently attempting to explain what’s going on and dissect what the executive order purports to do (some are even tracking different versions as well).So what’s hype/ what’s real — given this show’s throughline! — around what CDA 230 precisely does and doesn’t do, the role of agencies like the FCC, and more? What are the nuances and exceptions, and how do we tease apart the most common (yet incorrect) rhetorical arguments such as “platform vs. publisher”, “like a utility/ phone company”, “public forum/square” and so on? Finally: how does and doesn’t Section 230 connect to the First Amendment when it comes to companies vs. governments; what does “good faith” really mean and what are possible paths and ways forward among the divisive debates around content moderation? All this and more in this extra-long explainer episode of 16 Minutes, shared here for longtime listeners of the a16z Podcast. image: presidential tweet activity/ Wikimedia Commons

Given recent events around George Floyd and far beyond, this special episode of the a16z Podcast features Shaka Senghor, a leading advocate for criminal justice reform (and bestselling author), and Terry Brown, a former police officer in East Palo Alto (who has since run his own security firms) -- who, incidentally, both grew up in Detroit but ended up on different sides of the law -- in conversation with a16z co-founder Ben Horowitz.The conversation goes deep and on the ground (please note that the discussion also includes details of violence, in case you have young children listening).

For a SaaS company, it's easier to move upmarket than down, and this gives SaaS startups the advantage against incumbents. In this episode,  David Ulevitch and our newest enterprise general partner Kristina Shen look at the SaaS go-to-upmarket with a focus on how to price for the move, including why so many founders underprice, how to think about free versus paid trials, and navigating the transition to larger accounts.

Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engagement, and the increasingly blurred lines between sports, culture and tech.  We talked to NBA player Spencer Dinwiddie, of the Brooklyn Nets. Spencer created a new platform on the crypto blockchain Ethereum that gives fans the opportunity to invest directly in his revenue-generating potential, through debt securities.  Joining this conversation are a16z managing partner and tech investor Jeff Jordan, who has long followed the evolving relationship between sports and tech. Also joining is Jesse Walden, a former a16z crypto partner and co-founder of Mediachain. He’s also a former music promoter and manager whose focus was on helping artists stay independent.   We discuss the evolution of models for fan engagement; how social media has changed the game; and where technologies like cryptonetworks and blockchains come in.

Our understanding of the human brain and its disorders has always been limited by our lack of access to living, human, developing brain tissue. For the first time, that's changing. In this episode, Sergiu Pasca, Professor of Behavioral Science at Stanford, talks with a16'z General Partner Vijay Pande and Hanne Tidnam about the wild new tech that's pioneering a whole new approach to understanding the brain: brain organoids.So what are brain organoids, what are the scientific breakthroughs that lead to their creation, and how can we use them best? The conversation starts with the existing models we have used to learn about the living brain, from genetic studies to autopsies to primates—and what this new model now brings us: the ability to study the human brain, both how it develops and what goes wrong in certain disorders, with human brain tissue "alive" in a dish. We talk about what these organoids can and can’t do; what they’re good for understanding and where that understanding becomes limited; why calling these “brains in a dish” or “mini-brains” isn’t the right terminology at all; and finally, how far can this new tool and model be taken now and in the future, leading us closer towards understanding psychology itself on a molecular level.Image: Brain organoids derived in the Pasca Lab at Stanford University.

Pandemics are predictable; what's not predictable is the intensity, or the precise timing of arrival. That's where early detection -- not just rapid warning (as with something like Google Flu Trends back in the day), or even delayed warnings (as with CDC flu trackers and such) -- comes in. Because unfortunately, many disease tracking efforts old and new are "like watching the weather forecast a week after you've experienced that weather", observes a16z general partner Jorge Conde.And this matters for saving lives; for load balancing and allocating resources (ventilators, PPE, supplies); getting back to work; and much more. Even a two-week advantage could have made a huge difference! Which is what sociologist and physician Nicholas Christakis (who directs the Human Nature Lab, part of the Yale Institute for Network Science, and also author of the book Blueprint) learned from the H1N1 pandemic. Specifically, the role of social network "sensors" -- where friends in one's network graph can be like canaries in the proverbial coal mine to help detect pandemics earlier.In fact, the lab recently released an app called Hunala (which uses information crowdsourced among networks) to determine one's likelihood of contracting flu/ influenza-like or other respiratory illnesses through a personalized daily assessment of risk. Kind of like Waze, but for illnesses not car accidents. So in this episode of the a16z Podcast, the two take that analogy far. They also discuss the role of other mobility data and population flows in China for where and when the pandemic spread; the nuances behind "superspreaders"; how bad is the coronavirus, really; and the near future of "bio-surveillance" -- not just from a personal risk perspective, but from a global public-health perspective... Can we get the holy grail here without sacrificing privacy and agency?

This podcast (first recorded in 2019, now being rerun) -- is a podcast about podcasting: But it's really all about audio. A lot's changed... and a lot hasn't. How do we define "podcasts"; how does the feeds ecosystem currently work; what content and entertainment experiments might change how people not just consume, but create, in the medium? Not to mention monetize, discover, etc... Nick Quah, writer and publisher of Hot Pod (also at Vulture) joins a16z general partner Connie Chan -- and editor in chief (and showrunner of the a16z Podcast) Sonal Chokshi -- to talk about all this and more in this hallway-style jam.  The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.)Past performance is not indicative of future results. Any charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see https://a16z.com/disclosures for additional important information.

In normal times, every company operates against some hypothetical growth model—a data-driven framework that describes how your product grows and how you acquire new users. These, of course, are not normal times. In the fallout from the pandemic, most founders and CEOs are in the process of completely revamping their growth models from the bottom up amid new and unpredictable consumer behavior. This episode explores how to think about growth in turbulent times, according to two growth experts: a16z general partner Andrew Chen, who previously led the growth team at Uber, and Brian Balfour, formerly the VP of Growth at HubSpot, now the founder and CEO of Reforge, a masterclass in growth strategies (in conversation with host Lauren Murrow).The discussion spans four sections: first, how to reassess your existing growth model, particularly when, as Brian says, the data is "completely messed"; next, we drill down into strategy and tactics for surviving the current crisis and talk about how founders can pursue growth even in the midst of widespread uncertainty and cutbacks. Third, we look ahead to discuss scenario planning and how leaders can forge a path forward. Finally, we zoom out and assess the big picture: how various categories of company may be impacted long-term, how this crisis compares to 2008 (and what that means for early-stage founders), and the industries and business models that are now prime for growth.

In this episode of a16z bio Journal Club, general partner Vijay Pande, bio deal team partner Andy Tran, and bio editor Lauren Richardson discuss a novel CRISPR-Cas-based anti-viral strategy.The discussion covers the differences between this newly developed prophylactic strategy, traditional vaccines, and anti-viral drugs; how this strategy can be engineered to target a huge range of coronavirus and influenza strains; and the next steps needed to go from paper to practice:“Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza” in Cell (April 2020), by Timothy Abbott, Girija Dhamdhere, Yanxia Liu, Xueqiu Lin, Laine Goudy, Leiping Zeng, Augustine Chemparathy, Stephen Chmura, Nicholas Heaton, Robert Debs, Tara Pande, Drew Endy, Marie La Russa, David Lewis, and Lei Qia16z Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at a16z.com/journalclub.

Video game technology has evolved into a global phenomenon that extends far beyond entertainment. In this episode, John Riccitiello, CEO of the game software development company Unity Technologies, is interviewed by a16z general partner Andrew Chen on the rise of esports and streaming, the potential of cloud gaming, and  far-reaching applications for game technology. This conversation originally took place at our most recent innovation conference, the a16z Summit.

In this episode of the a16z Podcast, we take a deep dive into the world of drug development—specifically "undruggable drugs": a category of protein, protein family or even piece of RNA that’s so difficult to target that many researchers don’t even want to touch it. Jay Bradner, President of the Novartis Institute for BioMedical Research, shares with a16z General Partners Jorge Conde and Vijay Pande, and a16z's Hanne Tidnam, all the new tools, technologies and breakthroughs which are causing the science of therapeutics to explode in some of these areas where it's been incredibly difficult (even impossible) in the past. From molecular glues to cell and gene therapies, Bradner shares the behind-the-scenes science stories of what it really takes to make a new drug that shatters the category of an "undruggable" target.

This episode—which originally took place as a live event—is a conversation between Seattle Seahawks linebacker Bobby Wagner and a16z Cultural Leadership Fund partner Chris Lyons. Wagner is known for his power on the field and his business acumen off it. Last year, he negotiated his own three-year, $54 million contract extension to become the highest-paid middle linebacker in the NFL. In this candid conversation, Wagner and Lyons discuss how to identify standout companies and talent (for better or worse), the growing influence of cultural leaders in tech, and the potential of "shared genius."

The Chief Security Officer (CSO/CISO) used to manage on-premise servers, now the information they have to secure has migrated to the cloud. As the responsibility of CSOs has expanded, the role has moved from technical IT to the boardroom. How do the best CSOs prepare for and respond to a crisis, from redteaming to comms? What responsibility should cloud & SaaS vendors, not to mention the government, have in security and data breaches?  And how is the role going to evolve in the next five years? At our a16z Innovation Summit last year, we sat down with two security leaders whose career has evolved as the role has – Joe Sullivan, former CSO at Uber and Facebook, now at Cloudflare and Joel de la Garza, current security partner at a16z, formerly CISO at Box.

a16z Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). This inaugural episode covers 2 different topics, in discussion with Lauren Richardson:0:26 #1 identifying new antibiotics through a novel machine-learning based approach -- a16z general partner Vijay Pande and bio deal partner Andy Tran discuss the business of pharma; the specific methods/  how it works; and other applications for deep learning in drug discovery and development based on this paper:"A Deep Learning Approach to Antibiotic Discovery" in Cell (February 2020), by Jonathan Stokes, Kevin Yang, Kyle Swanson, Wengong Jin, Andres Cubillos-Ruiz, Nina Donghia, Craig MacNair, Shawn French, Lindsey Carfrae, Zohar Bloom-Ackermann, Victoria Tran, Anush Chiappino-Pepe, Ahmed Badran, Ian Andrews, Emma Chory, George Church, Eric Brown, Tommi Jaakkola, Regina Barzilay, James Collins11:43 #2 characterizing the novel coronavirus causing the COVID-19 pandemic -- a16z bio deal partner Judy Savitskaya shares what we can learn from the protein structures; the relationship to the 2002-2004 SARS epidemic; and more based on these two research articles: "Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein" in Cell (April 2020), by Alexandra Walls, Young-Jun Park, M. Tortorici, Abigail Wall, Andrew McGuire, David Veesler"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation" in Science (March 2020), by Daniel Wrapp, Nianshuang Wang, Kizzmekia Corbett, Jory Goldsmith, Ching-Lin Hsieh, Olubukola Abiona, Barney Graham, Jason McLellanYou can find these episodes at a16z.com/journalclub.

Announcing a16z Journal Club, a new show where we curate and discuss recent research papers with a16z experts and others. This new show continues the a16z Podcast mission of not just bringing you conversations about the future (as well as about building companies for this), but of also putting specific trends in context -- whether through news (as with our other show 16 Minutes), or, through journal articles (as with this new show -- which will soon have its own feed as well). The first episode, of bio journal club, focuses on why specific scientific advances matter from our perspective at the intersection of biology & technology. It is hosted by one of our a16z bio editors, Lauren Richardson, a former senior editor of open-access journal PLOS Biology with a background in cell and molecular biology and genetics (and with a Ph.D. from the University of Washington and a postdoctoral fellowship at UC Berkeley).You will hear it next in this feed, and can also find new episodes here as they come out every few weeks and at a16z.com/journalclub. ~sonal

Here is Ali's tweetstorm on the Narrow Waist of Blockchain Computing

“It's Time to Build” by Marc Andreessen. You can also find and share this essay at a16z.com/build

We wanted to let you know about a special new series of posts occasionally read out loud from us  (you can learn more about the why and why now in episode #500 on how we podcast); we may release these in a separate feed in future, for now, the first episode is next in this feed. Thank you for listening!You can also check out our other shows and series:16 MinutesHustlin' Tech

This episode of the a16z Podcast covers the the rise of online platforms that enable people to make a living off their unique interests and skills. It's a trend that's become increasingly relevant as the demand for virtual work grows. The discussion -- with Patreon cofounder and CTO Sam Yam and a16z consumer tech partner Li Jin in conversation with Lauren Murrow -- covers the new forms of work made possible by these online platforms, why creators today are effectively making more money off fewer fans, and what all of this means for the future of entrepreneurship.See more on the Passion Economy, metrics for it, 100 True Fans, and more at a16z.com/creatoreconomies.

with @JorgeCondeBio, @julesyoo, and @omnivorousreadIn some ways, the coronavirus feels like it came out of nowhere—a kind of Black Swan event. But at the same time, it's been exposing a lot of the fundamental flaws in our healthcare system that now feel like a perfect storm coming together... and have hurt our ability to address the problem that we should really have seen coming.In this episode, a16z General Partners Jorge Conde and Julie Yoo talk with Hanne Tidnam about some of those big forces and dynamics in the healthcare system, at the intersection of business, policy, and public health: how in healthcare like perhaps nowhere else, broken policy can lead to broken business models that, in the wrong circumstances, can then lead major failures in public health like the one we’re seeing today; where we’ve seen this before, in the markets of vaccines, antibiotics, and diagnostics; and what should be different next time, so that when a new pandemic hits we aren’t facing another perfect storm.

From agile project management to asynchronous collaboration, development teams have pioneered many of the tools and best practices for remote work. However, new shelter-in-place orders have more organizations moving to remote development -- and remote work -- often quickly and without a lot of time to plan.Will remote work be our new reality, even after the current pandemic? And if so, what are the current technologIes and practices that support organizational communication and alignment for distributed teams, development and otherwise? In this hallway-style podcast, Jason Warner, the CTO of GitHub, and a16z General Partner David Ulevitch cover how working from home is evolving our software as well as how we use it -- from communication tools and best practices to interviewing and hiring when you can’t see someone face to face.

with @vintweeta @pbcancerdoc @sumitshahmd @omnivorousreadCoronavirus is now disrupting the entire health care system, not just because of the burden of dealing with the actual disease itself, but because of everything else that's had to grind to a halt. One of the areas where we really worry about things coming to a total stop like that is, of course, cancer treatment, which can often feel like a race against the clock even under the best conditions.In this episode, Dr. Bobby Green, MD (Community Oncologist and Chief Medical Officer, Flatiron Health) and Dr. Sumit Shah (Oncologist and Head of Digital Health, Stanford Cancer Center) join a16z's Vineeta Agarwala (physician and general partner) and Hanne Tidnam to talk about what is happening to oncology during the outbreak—how treatment is affected; what kind of clinical decisions oncologists and patients are having to make, and how they're making them; the tech tools that specialists are using, and how they could improve; and what happens to oncology as a whole when it's forced to go virtual.

Descriptions of the mental illness we today call schizophrenia are as old as humankind itself. And more than likely, we are are all familiar with this disease in some way, as it touches 1% of us—millions of lives—and of course, their families. In this episode, we dive into the remarkable story of one such American family, the Galvins: Mimi, Don, and their 12 children, 6 of whom were afflicted with schizophrenia.In his new book, Hidden Valley Road: Inside the Mind of an American Family, Robert Kolker follows the family from the 1950s to today, through, he writes, "the eras of institutionalization and shock therapy, the debates between psycho-therapy versus medication, the needle-in-a-haystack search for genetic markers for the disease, and the profound disagreements about the cause and origin of the illness itself." Because of that, this is really more than just a portrait of one family; it’s a portrait of how we have struggled over the last decades to understand this mysterious and devastating mental illness: the biology of it, the drivers, the behaviors and pathology, the genomics, and of course the search for treatments that might help, from lobotomies to ECT to thorazine.Also joining Robert Kolker and a16z's Hanne Tidnam in this conversation is Stefan McDonough, Executive Director of Genetics at Pfizer World R&D, one of the genetic researchers who worked closely with the Galvins. The conversation follows the key moments where our understanding of this disease began to shift, especially with new technologies and the advent of the Human Genome Project—and finally where we are today, and where our next big break might come from.

For any business, there are three core financial statements – the income or P&L statement, the balance sheet, and the cash flow statement. While these statements can show investors and the board how the business is doing, they can do more than just keep score on your business – they are one of the best tools you have to run it.In this podcast, a16z General Partner and managing partner Jeff Jordan, who previously ran several businesses and took a company public right after the 2008 financial crisis; David George, who runs the a16z late-stage venture operation; and former CFO Caroline Moon, who leads the a16z financial operations team, break down what the numbers do (and don’t) tell you, both in financial statements and KPIs. They cover the most common mistakes people make when it comes to understanding their numbers; how investors look at a company's P&L; what metrics they use to determine if a business is healthy; and how founders can use the numbers to navigate in times of crisis.

Since social distancing measures were first put in place, time spent gaming has gone up—way up. According to a recent report by Verizon, video game usage in the U.S. has risen 75 percent during peak hours. The "stay at home" movement has given way to an upswell of new and returning gamers—as well as new challenges, as online platforms struggle to keep up with the surge.In this episode, a16z partner Jon Lai joins host Lauren Murrow to talk about how game developers are grappling with skyrocketing numbers, why this may be an inflection point for VR, the surprising transition of professional sports into esports, and why live-streaming is having its moment.

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for people. Recorded right before the coronavirus pandemic, these next 3 episodes touch on many things that are top of mind right now: from the profession of nursing and taking care of the elderly and the professionalization of caregivers; to fighting bureaucracy to get money back (and to now get help delaying utility bills and rent payments that are eligible for an extension or waiver of late fees due to the coronavirus crisis).Episode #6, “The Hustler’s Guide to Suing the Man” features:Joshua Browder, CEO and founder of DoNotPay, the world's first "robot lawyer" which helps people automatically fight bureaucracy to get money back, whether parking tickets or hidden bank fees; find other hidden money or cancel free trials; sue others or go to small claims court -- and now also helps people delay utility bills and rent payments that are eligible for an extension or waiver of late fees due to the coronavirus crisis.Makiri Duckett, a small business owner who currently operates an adult on-demand delivery service (and therefore gets frequent parking tickets) and is a power user of the platform;...both interviewed by Ben Horowitz and Shaka Senghor.You can find the first cycle of this series (Q4 2019) -- including more about the what and the why -- here.

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for people. Recorded right before the coronavirus pandemic, these next 3 episodes touch on many things that are top of mind right now: from the profession of nursing; to taking care of the elderly; to fighting bureaucracy to get money and time back (and to get help delaying utility bills and rent payments that are eligible for an extension or waiver of late fees due to the coronavirus crisis).Episode #5, “The Hustler’s Guide to Taking Care of Old Folks” features:Seth Sternberg, CEO and co-founder of Honor, a home care company and national network of local home care agencies that brings high-touch, personalized care to elders while also scaling workforce management; matching special needs, skills, and unique demands; and offering tools that help caregivers with jobs and more.Samantha Ludwig, a care professional who has always had a job thanks to Honor (and who journeyed from abroad as a foreign nurse);...both interviewed by Ben Horowitz and Shaka Senghor.You can find the first cycle of this series (Q4 2019) -- including more about the what and the why -- here.

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for people. Recorded right before the coronavirus pandemic, these next 3 episodes touch on many things that are top of mind right now: from the profession of nursing; to taking care of the elderly; to fighting bureaucracy to get money and time back (and to get help delaying utility bills and rent payments that are eligible for an extension or waiver of late fees due to the coronavirus crisis).Episode #4, “The Hustler’s Guide to Nursing Jobs” features:Iman Abuzeid, MD, CEO and co-founder of Incredible Health, a hiring platform for nurses in the U.S. used by hospitals and health systems that helps hospitals find nurses faster, offers free continuing education to nurses everywhere, and puts nurses at the center.Stephanie Anyanwu, RN, who found her nursing job on the platform and also journeyed to the U.S. from abroad;...both interviewed by Ben Horowitz and Shaka Senghor.You can find the first cycle of this series (Q4 2019) -- including more about the what and the why -- here.

This is the next cycle of Hustlin' Tech -- a podcast series co-hosted by bestselling authors, a16z co-founder Ben Horowitz; and Shaka Senghor, a leading voice in criminal justice reform.   Each episode is a "Hustler's Guide" to a new technology platform that creates opportunity for people. We previously released 3 episodes in this series last quarter, and this quarter are releasing 3 new episodes that follow in this feed, over the next few days. These episodes were all recorded right before the coronavirus pandemic. However, given what's going on in the world, they touch on many things that are top of mind right now: from the profession of nursing (including online communities and free continuing education from home); to taking care of the elderly (many of whom live alone or need other in-home assistance); and fighting bureaucracy to get money back -- or to get help delaying utility bills and rent payments that are eligible for an extension or waiver of late fees due to the crisis:#4 The Hustler's Guide to Nursing Jobs#5 The Hustler's Guide to Taking Care of Old Folks#6 The Hustler's Guide to Suing the Man  You can read more about the what and the why of the entire Hustlin Tech series -- and sign up to be notified about future episodes -- here.

We are in the midst of a rapid and unprecedented shift to remote work. What does it mean for security when the airgap between work and life is gone? How prepared are organizations? And what should security professionals as well as individual workers be doing to protect themselves and their companies?In this podcast, a16z security expert Joel de la Garza breaks down the current risks and how to defend against them. But beyond just immediate security needs, he explains what bigger transformations may be happening, most notably a shift from the traditional hub-and-spoke, point to point, security architectures to a more distributed approach to workloads as well as trust.

The spike in online ordering and food delivery—a trend that's particularly relevant now—is evidence of how tech is fundamentally changing how and what we eat. Is this the end of the traditional restaurant experience as we know it?In this conversation between Virtual Kitchen Co. CEO Ken Chong, Snackpass CEO Kevin Tan, a16z general parter Andrew Chen, and host Lauren Murrow, we discuss what's driving this transformation, the infusion of data into the restaurant industry, how take-out and delivery is becoming surprisingly social, and the specter of the "kitchenless home."Virtual Kitchen Co. is a network of delivery-only kitchens that partners with restaurants to expand their reach without opening additional brick-and-mortar locations. Snackpass is a food-ordering app currently on college campuses in which customers can order ahead at restaurants and skip the line. In this discussion, both CEOs explain what their business models could mean for the future of dining and cooking.This episode was recorded on-site at the a16z Summit in November 2019.

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We’re at a moment where we are now seeing medicine go virtual faster, and at a scale that it has never done before. In this conversation,  a16z bio general partners Vijay Pande and Julie Yoo, who come from the worlds of bio, technology and care delivery,  talk with Hanne Tidnam all about what exactly virtual care and “telemedicine” is... and what it isn’t; what it works well for, what doesn’t (yet), and where there’s potential; and finally, the current pain points (including regulation), and what we’ll learn from this current moment for the next generation of virtual medicine tools.

A lot's going on in the world of healthcare right now, and one topic that's especially relevant is how diagnostic labs work. In this episode with Dave King, Executive Chairman of Lab Corp (one of the largest clinical lab networks in the world) and a16z's General Partner Jorge Conde and Hanne Tidnam, we cover the evolution of the modern lab over the past 50 years, especially as new technologies and new tests are added; how tests go from specialized to mainstream and widely available; and who pays for most tests and how reimbursement affects all this. We also discuss where lab information flows—in electronic health records and in the health system at large—and touch on what the lab of the future might be like.

On February 21, Andreessen Horowitz kicked off its very first Crypto Startup School, with 45 students from around the U.S. and three countries gathering to learn how to build crypto projects. But just two weeks into the seven-week course, community spread of the novel coronavirus meant the school had to go remote — not just for the health and safety of everyone involved, but for others too, given the recommendations around social distancing and the importance of “flattening the curve”.Marketing partner Kim Milosevich and Jesse Walden, former founder of Mediachain who’s helping lead our Crypto Startup School, chat with a16z crypto editor Zoran Basich — in this hallway-style episode of the a16z Podcast — about virtual learning and collaboration in a new, uncharted world.

The last financial crisis prompted many consumers to reassess their banking expectations—none more so than millennials and Gen-Z-ers. While revealing one's financial information was once considered taboo, now consumers are more apt than ever to openly discuss money and debt on online platforms. It's a trend that's evident on both ends of the spectrum, whether that’s people divulging their crushing levels of debt on Twitter and Instagram (#debtfreejourney), bragging about their credit scores, or bemoaning their latest stock trades. And the repercussions extend far beyond social media. In this conversation with fintech general partner Anish Acharya (a former product manager at Credit Karma), consumer tech partner D'Arcy Coolican (a social+ fintech founder himself), and host Lauren Murrow, we discuss why the "holy grail" of social plus fintech is both so challenging and, potentially, so rewarding. We cover which products and companies are taking advantage of it (some in rather novel ways), how it's being driven by various subcultures online, and why this shift is happening now.

One of the recurring themes we talk about a lot on the a16z Podcast is how software changes organizations, and vice versa... More broadly: it’s really about how companies of all kinds innovate with the org structures and tools that they have. But we've come a long way from the question of "does IT matter" to answering the question  of what org structures, processes, architectures, and roles DO matter when it comes to companies -- of all sizes  -- innovating through software and more. So in this episode (a re-run of a popular episode from a couple years ago), two of the authors of the book Accelerate: The Science of  Lean Software and DevOps, by Nicole Forsgren, Jez Humble, and Jean Kim join Sonal Chokshi to share best practices and large-scale findings about high performing companies (including those who may not even think they’re tech companies). Nicole was co-founder and CEO of Dora, which was acquired by Google in December 2018; she will soon be joining GitHub as VP of Research & Strategy. Jez was CTO at DORA; is currently in Developer Relations at Google Cloud; and is the co-author of the books The DevOps Handbook, Lean Enterprise, and Continuous Delivery.

In 2014, in "Why There Will Never Be Another Red Hat," Peter Levine argued that Red Hat’s open source business model of commercializing support and services was highly difficult to replicate. Instead, he predicted the future of open source companies would be open source-as-a-service. And today SaaS has emerged as the dominant business model.In this podcast, recorded as a hallway-style conversation as part of the a16z Innovation Summit last year, Peter chats with Red Hat CIO, Mike Kelly, about what it means to be an open source CIO today – and how even Red Hat is evolving in the open SaaS era. They cover everything from why open hybrid has become the dominant enterprise architecture to how CIOs should think about adopting new technologies to what it takes for an M&A to be successful, beyond the spreadsheets.

This episode covers the following -- since our previous deep-dive on the novel coronavirus outbreak -- including:practical implications for the U.S. healthcare system given how it works today, and where we might go in the future — with a16z general partner Julie Yoo, given our vantage point in tech; andhow the rt-PCR test works — with a16z bio partner Judy Savitskaya;…in conversation with Sonal Chokshi.Sources for updates at top:CDC's latest briefing February 26, 2020, transcriptWHO situation report #27  February 25, 2020 [we covered #6 and #25 on previous episodes]Sources for last week's episode:latest numbers: cases in the U.S. (CDC, as of February 17, 2020); global cases (WHO situation report #25, February 14, 2020); spike in diagnosing cases as reported in China (SCMP, Scott Gottlieb)situation & policy statements/reports: CDC summary (as of February 14, 2020); “Annual report on global preparedness for health emergencies”, WHO (Global Preparedness Monitoring Board, 2019)on definitions (of pandemics, endemics), other terms, and various naming conventions: “Understanding pandemics: What they mean, what they don’t mean, and what comes next with the coronavirus”, Helen Branswell, StatNews (February 12, 2020); on disease occurrence and levels (CDC); “misinfodemic“; best practices on naming new human infectious diseases (WHO); qPCR (Keith Robison)image: CDC test kit for COVID-19/ Wikimedia Commons

It's "Marketplaces Week" for us at a16z, thanks to our consumer team releasing a new index of the next industry-defining marketplaces, the Marketplace 100.  But what happens as such marketplaces and other platforms evolve over time, as do their users? This episode is a rerun of a popular conversation from a couple years ago -- featuring general partners Andrew Chen and Jeff Jordan (in conversation with Sonal Chokshi) -- on what comes after user acquisition: retention. It's all about engagement. So what are the key metrics? And if different kinds of users join a  platform over time -- what does that mean for engagement, and where do cohort analyses come in?

Susan shares how she learned to leverage the characteristics of her personality early in her career as assistant secretary of state [2:05]One of the important conversations Susan had with a mentor that changed the trajectory of her career [4:50]Her parent’s commitment to education, their personal backgrounds, and the legacies they created [8:10]The result of instilling self-belief into children and mastering “psychological jiu jitsu” [10:22]What the early lessons of family diplomacy taught her [14:00]The importance of strategic compartmentalization [16:48]How to approach crisis during high stakes situations [18:29]How to practice compassionate leadership while maintaining effectiveness [20:10]Hacking the concept of “work-life balance” [21:10]The required characteristics of powerful leaders [28:14]The hard things about leadership and the idea of being liked [31:20]The “middle finger story”/the time Susan stood up for herself in an important meeting [33:23]Susan talks about China’s intelligence collection in the US [39:45]A call for unity between the private, public, and academic sectors [42:54]

with @OzAzamTmunity1, @JorgeCondeBio, and @omnivorousreadCAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer, has been so effective in childhood leukemias that we believe it may actually be a potential cure. But this isn't just one new medicine, it's an entirely new therapeutic tool—and a total paradigm shift from most traditional medicines we've seen before.Tmunity CEO Usman "Oz" Azam was previously the head of Cell and Gene Therapies at Novartis, in many ways the first CAR T company and the team brought us blood cancer CAR T-cell therapy Kymriah—the first cell-based gene therapy to be approved in the US. In this conversation, Azam discusses with a16z's general partner Jorge Conde and Hanne Tidnam what CAR T therapy really is and how it all works. The conversation begins with the “patient and cell journey” of this treatment and how this medicine is developed, manufactured, delivered to patients; why exactly it's so different traditional medicines; what it will take to make these new medicines work on more kinds of cancer, scale to more patients, and cost less; and finally, what company building lessons can be learned from building the first CAR T company of its kind from the ground up.This episode was recorded at the annual a16z Summit.

When we think about rebellious behavior in the context of organizations and companies, we tend to think of rebels as trouble-makers, rabble-rousers; in other words, people who make decisions and processes more difficult because they may not follow the established rules or norms. But rebel behavior can also be incredibly positive and constructive—in keeping us from stagnation, encouraging growth and learning, increasing curiosity and creativity.In this episode of the a16z Podcast, Harvard Business School Professor Francesca Gino, a social scientist who studies organizations, breaks down with a16z's Hanne Tidnam what makes rebels different in how they tend to see and do things—whether that’s cooking, flying planes, or holding board meetings—and what we can all learn from “rebel talent” to make our organizations more productive and innovative.

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it's an ongoing and fast-developing news cycle, we take a quick snapshot for where we are, what we know, and what we don't know, and discuss the vantage point of where tech comes in. Topics covered include:definition of a virus, categories of coronavirusesorigins and spreadhow this stacks up so far against SARS and MERSspeed of sequencing, implications of genomic infospeed of information sharingR0 ("r-naught"/"nought") and what it measuresdifferent ways to think about how bad a given epidemic iscurrent moves and treatmentsOur a16z guest is Judy Savitskaya on the bio team, in conversation with Sonal Chokshi.Link sources or background readings for this episode:Centers for Disease Control and Prevention (in the U.S. Department of Health and Human Services) + typesWorld Health Organization (in the United Nations) -- situation report #6, January 26Other background readings / pieces mentioned in this episode: "Scientists are moving at record speed to create new coronavirus vaccines--but they may come too late", Jon Cohen, Science (AAAS), January 27"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", The Lancet, January 24"Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin", bioRxiv, January 2 *note - preprint, NOT peer reviewed*"The deceptively simple number sparking coronavirus fears", Ed Yong, The Atlantic, January 28 *this appeared AFTER this episode was recorded, so sharing here as additional reading only*image: CDC

The idea of "1000 true fans" -- first proposed by Kevin Kelly in 2008 and later updated for Tools of Titans -- argued that to be a successful creator, you don’t need millions of customers or clients, but need only thousands of true fans. Such a true, diehard fan "will buy anything you produce", and as such, creators can make a living from them as long as they: (1) create enough each year to earn profit from each fan, plus it's easier and better to give existing fans more; (2) have a direct relationship with those fans, which the internet (and long tail) now make possible.But patronage models have been around forever; what's new there? How has the web evolved; and how are media, and audiences/voices finding and subscribing to each other changing as a result? If the 1000-true-fans concept is also more broadly "useful to anyone making things, or making things happen" -- then what nuances do people often miss about it? For instance: That there are also regular fans in the next concentric circle around true fans, and that the most obscure node is only one click away from the most popular node.Finally -- when you combine this big idea with another idea Kelly proposed in his most recent book The Inevitable (covered previously on this episode) on inverting attention economies so audiences monetize their attention vs. the other way around, how do we connect the dots between them and some novel thought experiments? In this hallway-style episode of the a16z Podcast, which Sonal Chokshi recorded with Kevin in our pop-up podcast booth at our most recent a16z Summit, we discuss all this and more. Because on average, we all currently surrender our attention (whether to TV, books, or whatever) for about $3 an hour. Whoa?! image: whatleydude/Flickr

We've been financing good writing with bad advertising -- and "attention monsters" (to quote Craig Mod) for way too long. So what happens when the technology for creators finally falls into place? We're finally starting to see shift in power away from publications as the sole gatekeepers of talent, towards individual writers. Especially when the best possible predictor of the value of a piece of writing is, well, the writer. The publication's brand is no longer the guarantee of quality, or the only entity we should be paying and be loyal to, when a new ecosystem is forming around the direct relationship between consumers, content creators, and the tools and business models to facilitate all this.So where do readers come in... how do they find signal in the noisy world of drive-by billboard advertising, "attention-monster" feeds, and the death of Google Reader? Particularly as machine learning-based translation, summarization, and other mediums beyond text increasingly enter our information diets, for better and for worse?This episode of the a16z Podcast features Robert Cottrell, formerly of The Economist and Financial Times and now editor of The Browser (which selects 5 pieces of writing worth reading delivered daily); Chris Best, formerly CTO of Kik and now co-founder and CEO of Substack (a full-stack platform for independent writers to publish newsletters, podcasts, and more); and Andrew Chen, formerly independent blogger/ newsletter publisher, now also an a16z general partner investing in consumer -- all in conversation with Sonal Chokshi. The discussion is all about writing and reading... but we're not just seeing this phenomenon in newsletters and podcasting, but also in people setting up e-commerce shops, video streaming, and more. Is it possible that the stars, the incentives, are finally aligning between creators and consumers? What happens next, what happens when you get more than -- and even less than -- "1000 true fans"? image: Thad Zajdowicz/ Flickr

How can we evolve the web for a better future? Has the web become a mature platform — or are we still in the early days of knowing what it can do and what role it might have in our lives? Just as “social/local/mobile” once did, what are the new trends — like crypto and blockchain networks and commerce everywhere — that might converge into new products and experiences?Chris Dixon (general partner at a16z and co-lead of the a16z crypto fund) discusses all things internet with Jonah Peretti (founder and CEO of BuzzFeed). Their conversation ranges from the early days of the web to the way innovation happens (what Chris calls “outside-in vs inside-out”) to the promise of a community-owned and operated internet, and more.Together they explore the possibilities that could co-evolve and converge are we enter into the next era of the web, and they share how we might not be quite as far removed from the “wild west days” of the internet as we imagined.

AI can do a lot of specific tasks as well as, or even better than, humans can — for example, it can more accurately classify images, more efficiently process mail, and more logically manipulate a Go board. While we have made a lot of advances in task-specific AI, how far are we from artificial general intelligence (AGI), that is AI that matches general human intelligence and capabilities?In this podcast, a16z operating partner Frank Chen interviews Stuart Russell, the Founder of the Center for Human-Compatible Artificial Intelligence (CHAI) at UC Berkeley. They outline the conceptual breakthroughs, like natural language understanding, still required for AGI. But more importantly, they explain how and why we should design AI systems to ensure that we can control AI, and eventually AGI, when it’s smarter than we are. The conversation starts by explaining what Hollywood's Skynet gets wrong and ends with why AI is better as "the perfect Butler, than the genie in the lamp."

The federal agency known as the FDA, or the Food and Drug Administration, was born over 100 years ago—at the turn of the industrial revolution, in a time of enormous upheaval and change, and rapidly emerging technology. The same could be said to be just as true today. From CRISPR to synthetic biology to using artificial intelligence in medicine, our healthcare system is undergoing massive amounts of innovation and change. Covering everything from gene-editing your dog to tracking the next foodborne outbreak, this wide-ranging conversation between Principal Commissioner of the FDA Amy Abernethy and Vijay Pande, GP on the Bio Fund at a16z, discusses how the agency is evolving to keep pace with the scientific breakthroughs coming, while staying true to its core mission of assessing safety and effectiveness for consumers in the world of food and medicine. Highlights:What the FDA looks like today and the key steps of the FDA process to getting a drug/product to market [2:20] How to manage a culture when mitigating risk is a top priority while aiming to innovate for the future [5:22] Creative problem-solving in times of crisis, such as the Opioid crisis [9:58] Preparing for and preventing drug shortages at scale [13:30] How advances in bioengineering are transforming healthcare [16:00] How the FDA is thinking about n=1 therapies and its applications in the future [18:54] The future of healthcare privacy [26:10] The ways the clinical trial process are shifting [29:26] Innovations in Bioengineering as they relate to regulating food in the future [36:02] How the FDA handles foodborne illnesses and its plans to innovate food safety [39:12] Discussion about the next 100 years of the FDA [41:25]

How does the world’s largest producer of medicines in terms of volume balance the science and the business of innovation? How does an enterprise at such vast scale make decisions about what to build vs. buy, especially given the fast pace of science today? How does it balance attitudes between “not invented here” and “not invented yet”?Vas Narasimhan, CEO of Novartis, sat down with a16z bio general partners Jorge Conde and Vijay Pande, and editor in chief Sonal Chokshi, during the JP Morgan Healthcare Conference around this time last year, to discuss the latest trends in therapeutics; go to market and why both big companies and bio startups need to get market value signals (not just approvals!) from payers earlier in the process; clinical trials, talent, leadership, and more in this rerun of the a16z Podcast. image: Global Panorama/ Flickr

This is a turn of the decade (and January-themed) look backward/ look forward into personal genomics, given recent and past retrospective and prospective pieces in the media on the promise, and perils, of the ability to sequence one's DNA: What did it, and does it, mean for personalized medicine, criminal investigations, privacy, and more?General partner Jorge Conde, who has a long history in the space, covers everything from where genealogy databases and large datasets come in to fetal testing, multi-omics, and other themes spanning the past, present, and future of personal genomics in conversation with Sonal Chokshi for episode #18 our news show 16 Minutes, where we cover recent headlines, the a16z way, from our vantage point in tech -- and especially what's hype/ what's real. While we typically cover multiple headlines, this is one of our special deep-dive episodes on a single topic. (You catch up on other such deep dives, on the opioid crisis and other evergreen episodes, at a16z.com/16Minutes). And if you haven't already, be sure to subscribe to the separate feed for "16 Minutes" to continue getting new episodes. image: Petra Fritz / Flickr

Many skeptics thought the internet would never reach mass adoption, but today it’s shaping global culture, is integral to our lives -- and it's just the beginning. In this conversation from our 2019 innovation summit, Kevin Kelly (Founding Executive Editor, WIRED magazine) and Marc Andreessen sit down to discuss the evolution of technology, key trends, and why they're the most optimistic people in the room.***The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

When innovation and capital go global, so do restrictions on trade, foreign investment, and more. Over the past couple years, U.S. policymakers have expanded the scope of the Committee on Foreign Investment in the U.S. (CFIUS) through the Foreign Investment Risk Review Modernization Act (FIRRMA) of 2018 which was recently updated through proposed reforms this September 2019.So what does this all mean for tech founders taking investments from, or doing joint ventures with, foreign entities -- or just doing business globally in general? What does and doesn't CFIUS cover, and how might one structure partnerships strategically as a result? In this episode, a16z general partner Katie Haun interviews Michael Leiter (of law firm Skadden Arps) who specializes in CFIUS as well as matters involving U.S. national security and cybersecurity, cross-border transactions, aerospace and defense mergers and acquisitions, and government relations and investigations.The Q&A took place in September 2019 as part of an event hosted by Andreessen Horowitz. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

A bold proposal: You go to college for free, then pay back the school after graduation—but only if you get a job in your field of study and make a high enough salary to afford it. It's called an income share agreement, and Austen Allred, the CEO and cofounder of Lambda School, thinks it's the future of education.Student debt currently stands at more than 1.5 trillion dollars, which makes it the second-highest consumer debt category behind mortgage debt. The crisis has saddled much of a generation, with far reaching effects. Income share agreements, or ISAs, have been put forth as an alternative to the current system. Put simply, an ISA is an agreement between a school and a student for the student to pay a defined percentage of income to the school, for a particular period of time, up to a certain cap. It's a seemingly simple conceit with complex design considerations, and it's spurring debate across media and politics.In this episode, Lambda School CEO Austen Allred, a16z general partner D'Arcy Coolican, and a16z editorial partner Lauren Murrow delve into the greater implications ISAs may have for education and the economy. The discussion covers both the promise and the challenges of ISAs—why they've been relatively slow to gain traction, why they've failed in the past, and why some in the political sphere are still skeptical.

Hollywood and Silicon Valley seem so different, but are more alike than we think. What challenges do tech startup founders and other creative founders -- like showrunners and executive producers -- similarly face? Both have to deeply understand and respect their audiences; learn how to scale themselves beyond one person; and even figure out how and when to use data... or follow their intuitions.In the end, it’s all about creating a story (product!) that sticks.In this conversation with Andreessen Horowitz cofounder and general partner Marc Andreessen, Shonda Rhimes -- executive producer, writer, creator of hit 100+ episode shows hows like Grey’s Anatomy and Scandal, and founder of the media company Shondaland -- shares the mindsets that drive her to pitch ideas, think about new mediums, and what happens when make believe veers too close to reality.Rhimes is the recipient of several industry awards and accolades, including a Golden Globe for Outstanding Television Drama, the Peabody Award, Time 100 most influential people, Fortune's “50 Most Powerful Women in Business", and lifetime achievement awards from the Directors Guild of America, the Writers Guild of America, and the Producers Guild of America. She has been inducted into the National Association of Broadcasters Broadcasting Hall of Fame and to the Television Academy of Arts & Sciences Hall of Fame. She is also the creative director of Dove’s #RealBeauty campaign and authored NYT bestseller Year of Yes.The conversation originally took place at our most recent annual innovation Summit -- which features a16z speakers and invited experts from various organizations discussing innovation at companies large and small, as well as tech trends spanning bio, consumer, crypto, fintech, and more.

As part of a new series where we will share select a16z partner appearances on other podcasts with our audience here, this episode is cross-posted from the new show Starting Greatness -- featuring interviews with startup builders before they were successful -- hosted by Mike Maples junior.In the conversation, a16z co-founder Marc Andreessen shares some rare, behind-the-scenes details of his story from 0 to 1 -- from the University of Illinois and Mosaic to Netscape -- and along the journey, really, to product-market fit...

We’ve covered a lot of the strategic financing milestones for startups seeking to build a sustainable and enduring business -- from mindsets for startup fundraising to when and how to build a finance functionwith a CFO to what it takes to do an initial public offering (IPO) and stories from the inside out. There’s also a lot that goes on behind the scenes en route to IPO, including how they’re priced and what the "pop" means.Yet another route to the public markets is the direct listing, recently reinvented for tech companies (with Spotify and Slack so far). We explained the process and tradeoffs in this early primer by Jamie McGurk, so this episode of the a16z Podcast brings together two experts from the frontlines: the architect of the direct listings in their current form, Barry McCarthy, current CFO of Spotify (and former CFO of Netflix); and Stacey Cunningham, president of the NYSE where they were listed -- in conversation with Sonal Chokshi to share more about the what, the how, and the why from an insider perspective.What's the bigger picture here, including secular shifts in the public and private markets? Zooming in closer, what are all the details and nuances involved in true pricing, investor days, forward guidance, and other market mechanisms for "radical transparency"? What did it take behind the scenes to make this all happen, and what's still happening? And finally, what are some of the common myths and misconceptions around direct listings (and IPOs) as methods for going public? Turns out, there's a lot that goes into making markets... and market making.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

There are some common tropes that can kill your company culture -- whether it's that corporate values can be weaponized; "fake it til you make it"; the "reality distortion fields" of visionaries vs. liars; and so on. All of this just reveals the confusing, sometimes blurry line between the yellow zones and red zones of behavior, because the very things that are strengths can also become weaknesses (and vice versa!). The fact is, in any complex adaptive system (which is what a company is), even the seemingly smallest behaviors will move the culture where the loudest proclamations do not.That's why so much of culture -- whether building and setting it or fixing and changing it -- comes down to the difference between actions and words, to the tacit vs. the explicit, to the difference between what you do vs. what you say (and what employees see vs. what they hear). So in this episode of the a16z Podcast, based on a conversation that recently took place at the Computer History Museum in Silicon Valley, Sonal Chokshi interviews Ben Horowitz about his new book, What You Do Is Who You Are, probing on all the tricky nuances of the themes covered in it -- and also how to practically apply principles from it to the tech industry and beyond.Are mistakes of omission more important than mistakes of commission, when it comes to ethical lines? What can employees, not just leaders, do when it comes to culture? Where does the idea of "culture fit" come in? What happens when startups go from being the pirates to being the navy? Drawing on examples of culture as code from a thousand years ago to today -- spanning empires, wars, revolutions, prisons, and even hip-hop -- Horowitz shares the power of song and story. Including even violent, "shocking" ones that reset cultures... because they make you ask, WHY?!100% of the proceeds from the book will go to anti-recidivism, and to making Haiti great again

This podcast rerun -- first recorded over two and a half years ago, now being rerun as one of our evergreen classics on the tails of the world's largest designated shopping days (Black Friday, Singles Day in China, Prime Day online, and so on) -- is ALL about the container ship. Also known as "The Box", with author Marc Levinson (in conversation with Sonal Chokshi and Hanne Tidnam). But this episode is really about connecting the dots between logistics, transportation, infrastructure, and much more.What do we make of the so-called "death of retail", especially when seen through the retail history of the once-largest retailer in the world? How are supply chains changing today? One thing's for sure: the shipping container made the world much smaller... and the world much economy bigger. image: Kevin Talec / Flickr

"Constant attention by a good nurse may be just as important as a major operation by a surgeon”, diplomat Dag Hammarskjöld once observed -- and that may be more true today than ever before. For most of us, nurses are essentially the face of the healthcare system: the person you’ll see the most of while you’re in it, who will monitor your vitals, administer medications, hold your hand when you’re in pain or scared, answer all the questions you forgot to ask the doctor.So in this episode, we take a look at the role of that unsung hero of healthcare -- the nurse -- at an industry level. Iman Abuzeid, CEO and co-founder of Incredible Health (a hiring platform for nurses), and a16z general partners Julie Yoo and Jeff Jordan discuss with Hanne Tidnam how the scope of the job is changing today and why; what’s driving the looming nursing shortage crisis, and ways we can help solve it; what it’s like to build a new marketplace platform in healthcare; and how best to introduce innovation into the healthcare system overall.

"Hi everyone, welcome to the a16z Podcast..." ... and welcome to our 500th episode, where, for the first time, we reveal behind-the-scenes details and the backstory of how we built this show, and the broader editorial operation. [You can also listen to episode 499, with head of marketing Margit Wennmachers, on building the a16z brand, here.]We've talked a lot about the podcasting industry, and even done podcasts about podcasting, so for this special episode, editor-in-chief and showrunner Sonal Chokshi reveals the how, what, and why in conversation with a16z general partner (and guest-host for this special episode) podcasting fan Connie Chan. We also answer some frequently asked questions that we often get (and recently got via Twitter), such as:how we program podcastswhat's the process, from ideas to publishingdo we edit them and how!do guests prep, do we have a scripttechnical stack...and much more. In fact, much of the conversation goes beyond the a16z Podcast and towards Sonal's broader principles of 'editorial content marketing', which hopefully helps those thinking about their own content operations and podcasts, too. Including where podcasting may be going.Finally, we share some unexpected moments, and lessons learned along the way; our positions on "tics", swear-words, and talking too fast; failed experiments, and new directions. But most importantly, we share some of the people behind the scenes who help make the a16z Podcast what it was, is, and can be... with thanks most of all to *you*, our wonderful fans!

Many technical founders, academics, and other experts often believe that great products -- or great ideas! -- sell themselves, without any extra effort or marketing. But in reality, they often need PR (public relations).The irony is, most of the work involved in PR is actually invisible to the public -- when it works, that is -- and therefore hard for those from the outside to see let alone understand. So how does such brand-building really work? In this 10-year anniversary episode of the a16z Podcast (and our 499th episode), a16z operating partner Margit Wennmachers shares the case study of her work at The Outcast Agency (which she co-founded) and of building the a16z brand (where she heads marketing and was the first and one of the earliest hires).What's the backstory there? What's the backstory behind some of the most popular media stories and op-eds -- like "software is eating the world" -- and what can it teach us about how PR and brand-building works in practice? Because -- like many software companies -- the product is so abstract, and not something you can physically touch, what kind of subtle decisions and tactics big and small does it take? Answering some frequently asked questions (in conversation with editor in chief Sonal Chokshi) that we often get around how things work, Wennmachers reveals (just some;) of the details behind the scenes. Given that technology is all about disintermediating "brokers" in the middle, will tech one day replace PR? And finally, what's the hidden Silicon Valley network mafia that NO one talks about?

The games industry is in the midst of a tectonic shift. Powered by platform convergence, games-as-a-service, and user-generated content, modern video games—what we call next-generation games—are unlike anything we've seen before. In the past decade, gaming has grown from a niche hobby into a global, culture-defining phenomenon.Not only are the games themselves becoming increasingly immersive, the way we develop and discover them has fundamentally changed. In contrast to the hits-driven business model of the past, now games are shaped in real time by player feedback. And thanks to the rise of influencer gamers, the experience of finding new games has become organic and social.In this episode, a16z general partner Andrew Chen, deal partner Jon Lai, and host Lauren Murrow discuss how gaming is dominating not only the entertainment industry, but also pop culture at large. (Why can't we quit you, Untitled Goose Game?!) Andrew and Jon share how they think about emerging technologies in the space, as well as the features they look for in next-gen games and game developers.

Consumer software may have adopted and incorporated AI ahead of enterprise software, where the data is more proprietary, and the market is a few thousand companies not hundreds of millions of smartphone users. But recently AI has found its way into B2B, and it is rapidly transforming how we work and the software we use, across all industries and organizational functions. In this episode, Das Rush interviews Oleg Rogynskyy, founder of People.ai, an AI platform for sales and marketers, and Peter Lauten from the a16z Enterprise investing team about what the rise AI in B2B means for enterprises, workers, and startups. They explain why AI provides a strong first mover advantage to enterprises that adopt it early; how it can automate lower level tasks, maximize our focus, and, ultimately, make our work more meaningful; and for startups, they provide a playbook for seizing the next AI opportunity.

Today, despite the critical importance of open source to software, it’s still seen by some as blasphemous to make money as an open source business. In this podcast, Armon Dadgar, Cofounder and CTO of HashiCorp; Ali Ghodsi, CEO of Databricks; and a16z General Partner Peter Levine explain why it's necessary to turn some open source projects into businesses.They also cover the most important questions for open source leaders to answer: How do you keep community engaged while building a business? What new opportunities does SaaS (software-as-a-service) present? And if you are a SaaS business, how should you approach cloud service companies, like Amazon Web Services (AWS)?

This rerun podcast (first recorded in 2015, now being rerun as one of our evergreen classics/ favorites) -- is ALL about emoji. But it's really about how innovation really comes about: through the tension between open standards vs. closed/ proprietary systems; the politics of time and place; and the economics of creativity, from making to funding.So yes, this podcast is all about emoji. But it's also about where emoji fits in the taxonomy of social communication, and why that matters -- from making emotions machine-readable to being able to add "limbic" visual expression to our world of text. And if emoji is a language, why can't we translate it; why so ambiguous?? How do emojis work, both technically underneath the hood... and in the (committee) Room Where It Happens?Joining this episode are former VP of Data at Kickstarter Fred Benenson (and the man behind 'Emoji Dick'); and former New York Times reporter and current Unicode Emoji subcommittee vice-chair, Jennifer 8. Lee (and one of the women behind the dumpling emoji) -- in conversation with Sonal Chokshi.image: Yiying Lu (@yiyinglu)

It used to be that the only way for humanity to grow -- and progress -- was through destroying the environment. Sure, the Industrial Revolution brought about the growth of our economies, our population, our prosperity; but it also led to our extracting more resources from the planet, more pollution, and some nightmarish human conditions as well. But is this interplay between the two -- of human growth vs. environment, of protection vs. destruction -- really a zero-sum game? Even if it were true in history, is it true today? How about for developing economies around the world today -- do they have to go through an extractive phase first before entering a protective one... or can they skip that phase altogether through better technology (the way they leapt to mobile)?And if capitalism is not responsible for environmental degradation, than who or what is? Where does technology come in, and where doesn't it -- if you believe we already have the answers to saving the environment? Marc Andreessen and Sonal Chokshi interview MIT economist Andrew McAfee about all this and more, given his new book, More from Less: The Surprising Story of How We Learned to Prosper Using Fewer Resources -- and What Happens Next.So what does happen next? From nuclear power to dematerialization to Tesla and the next cleantech revolution (or not), this episode of the a16z Podcast brings a different perspective to an important discussion around taking care of our planet... and also ensuring human progress through the spread of human capital and technology. image: Kevin Gill / Flickr

Our news podcast, 16 Minutes -- where we quickly cover the top headlines of the week, the a16z way (why are these topics in the news; what's real, what's hype from our vantage point of tech trends) -- is now only available as its own show feed, separately from the main a16z Podcast... so be sure to subscribe wherever you get your podcasts if you want our weekly news & tech take!This is the tenth episode of the show, and this week we cover a variety of topics with the following a16z experts:Amazon Care healthcare news this week that they're now providing a virtual medical clinic for employees, initially in Seattle, using telemedicine and in-home visits; what does their delivering healthcare actually mean for both incumbents and startups... and the future of medicine? -- with Julie Yoo and Jorge CondeOculus Connect 6, Facebook's annual developer event, where there were a number of announcements about devices, content, and more that could be key to the evolution of virtual reality (VR) and augmented reality (AR) -- with Chris DixonGoogle quantum supremacy claim, as shared in a paper with/via NASA; what's fact, what's fiction about it; what does it actually mean (or not mean) for cryptography and other applications; and where are we, really, in quantum computing? -- with Vijay Pande...hosted by Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.