Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret
Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret  
Podcast: DarkHorse Podcast
Published On: Mon May 02 2022
Description: Bret speaks with Alexandros Marinos, who has analyzed the TOGETHER trial, which aims to identify effective repurposed therapies to prevent the disease progression of COVID-19.Alexandros is the Founder/CEO of http://balena.io & aspiring practical philosopher. Find him on:https://twitter.com/alexandrosmhttps://doyourownresearch.substack.com/Mentioned in this episode:https://www.togethertrial.com/https://doyourownresearch.substack.com/p/the-problem-with-the-together-trial*****Find Bret Weinstein on Twitter: @BretWeinstein, and on Patreon.https://www.patreon.com/bretweinsteinPlease subscribe to this channel for more long form content like this, and subscribe to the clips channel @DarkHorse Podcast Clips for short clips of all our podcasts:https://www.youtube.com/channel/UCAWCKUrmvK5F_ynBY_CMlIAAll removed videos can be found on Spotify Video and Odysee: https://open.spotify.com/show/57R7dOcs60jUfOnuNG0J1Rhttps://odysee.com/@BretWeinstein:fCheck out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: http://www.store.darkhorsepodcast.orgTheme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.*****Sign up for the Spectator at: https://spectatorworld.com/specialoffer/Use code: DARKHORSEFarrow SkinFood is lard-based skincare that nourishes the skin without preservatives or added chemicals.Go to http://farrow.life/darkhorse for 20% off your first purchase; additional 15% off with a recurring subscription.*****Timestamps:(00:00) Introduction(03:11) Better Skeptics project – analyzing COVID podcasts(08:12) TOGETHER trial and its timeline(15:35) Ads(19:08) Dosage & initial TOGETHER trial design (25:29) Confusing paper and placebo group dropout?(31:23) IVM dose too low and new protocol(35:04) Trial recruitment over time and key 10-week period(43:42) Systemic errors(51:33) Placebo arm from earlier period?(57:11) Trial data not being released(01:02:27) Exclusion criteria flipped(01:06:38) Hypothesis on algorithm rebalancing arms(01:13:35) Allocation to Fluvoxamine arm(01:17:12) TOGETHER trial authors believe IVM has an effect(01:20:15) Credible intervals and Bayesian statistics(01:25:55) Will we ever get the full story? (01:30:28) Dosing and weight limit(01:34:52) Background use of IVM in Brazil(01:47:19) “Independent” committee monitoring trial(01:54:29) Cavallo study and inconsistency in response(01:57:41) Press releases and cold confusion(02:09:27) Wrap upSupport the show